Original title: Sensitivity of action potential to changes of inward rectifier potassium current IK1 is different in recent models of human ventricular cardiomyocytes
Authors: Pásek, Michal ; Šimurda, J. ; Christé, G.
Document type: Papers
Conference/Event: Engineering Mechanics 2014, Svratka (CZ), 2014-05-12 / 2014-05-15
Year: 2014
Language: eng
Abstract: The inwardly rectifying potassium current IK1 is one of the principle ionic currents responsible for repolarization phase of mammalian action potentials (APs). To estimate the impact of individual ionic currents on AP configuration, mathematical models have been widely used. In this study, we compared the effects of alcohol-induced changes of IK1 on AP duration (APD) as simulated in four recently published computer models of human ventricular cells. As expected, increasing or decreasing IK1 conductance by 20% respectively caused a shortening or a lengthening of APD. However, the effect was largely model-dependent, ranging from 1% to about 15% change of APD. Given the conflicting available experimental data on the features of IK1 in human ventricular myocytes there is a need for a set of well-established end-point constraints for a reliable human ventricular myocyte model to be generated.
Keywords: action potential; human ventricular cardiomyocyte; human ventricular cell model; inward rectifier potassium current
Host item entry: Engineering mechanics 2014, ISBN 978-80-214-4871-1, ISSN 1805-8248

Institution: Institute of Thermomechanics AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0241753

Permalink: http://www.nusl.cz/ntk/nusl-180424


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