Original title: Computational study of cellular assembly on hydrophobic/hydrophilic micro-patterns
Authors: Ukraintsev, Egor ; Brož, A. ; Kalbáčová, M.H. ; Kromka, Alexander ; Rezek, Bohuslav
Document type: Papers
Conference/Event: International Conference NANOCON /6./, Brno (CZ), 2014-11-05 / 2014-11-07
Year: 2015
Language: eng
Abstract: We develop simple onedimensional stochastic model of cell behavior on chemically patterned surfaces that is based on three key parameters: speed of cell movement (motility) across substrate, probability of cell adhesion to substrate, and probability of cell division on substrate when adhered on substrate. Amount of adhered cells on hydrophobic and hydrophilic regions is calculated as function of time (number of cycles up to 2000). The model is correlated with in-vitro data obtained within 48 h in real time. We show that this simple stochastic model with the three parameters (where cell motility is the most important one) can describe with high accuracy the experimental data and thereby explain the observed preferential cell assembly on hydrophilic/hydrophobic micro-patterns (up to 200 um width).
Keywords: adhesion; cell movement; SAOS-2 cells; stochastic computer simulations
Project no.: GAP108/12/0996 (CEP)
Funding provider: GA ČR
Host item entry: NANOCON 2014, 6th International Conference, ISBN 978-80-87294-53-6

Institution: Institute of Physics AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0238686

Permalink: http://www.nusl.cz/ntk/nusl-177575


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