Original title: Enzymes of Purine Salvage Pathway in \kur{Trypanosoma brucei} and the Trypanocidal Action of Acyclic Nucleoside Phosphonates
Authors: KOTRBOVÁ, Zuzana
Document type: Master’s theses
Year: 2014
Language: eng
Abstract: This study aims to functionally characterize two enzymes, HGPRT and XPRT, of an essential purine salvage pathway in the infection stage of Trypanosoma brucei. Localization, in vivo function and in vitro activity of these enzymes were characterized. Effect of acyclic nucleoside phosphonates, putative inhibitors of HGXPRT, on the viability of bloodstream form of T. brucei was evaluated.
Keywords: Purine salvage pathway; Trypanosoma brucei
Citation: KOTRBOVÁ, Zuzana. Enzymes of Purine Salvage Pathway in \kur{Trypanosoma brucei} and the Trypanocidal Action of Acyclic Nucleoside Phosphonates. České Budějovice, 2014. diplomová práce (Mgr.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/32360

Permalink: http://www.nusl.cz/ntk/nusl-173162


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Master’s theses