Original title: Formation of Fe-S clusters in the mitochondrion of Trypanosoma brucei
Authors: CHANGMAI, Piya
Document type: Doctoral theses
Year: 2013
Language: eng
Abstract: This thesis focuses on iron sulfur (Fe-S) cluster biogenesis by the ISC machinery in the mitochondrion of Trypanosoma brucei. Most of proteins in the pathway show conserved functions, while some features are distinct from their counterparts in other organisms. We also show here the essentiality of the ISC machinery in bloodstream stage despite the fact that the parasites contain the rudimentary mitochondrion in this stage. The key player for the ISC export machinery, which is indispensable in the maturation of extra-mitochondrial Fe-S proteins, shows some extraordinary phenomena which may imply the moonlighting function of the protein. I also show preliminary data of an ongoing project concerning a putative heme transporter. The results indicate role in heme uptake of the protein, but further study is required to confirm the function of the protein.
Keywords: Fe-S cluster biogenesis; Fe-S proteins; heme; ISC export machinery; ISC machinery
Citation: CHANGMAI, Piya. Formation of Fe-S clusters in the mitochondrion of Trypanosoma brucei. České Budějovice, 2013. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/18263

Permalink: http://www.nusl.cz/ntk/nusl-156659


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Doctoral theses