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The analysis of pharmacotherapy in patient suffered with dyslipidemia in Greece I.
Mavrovouniotis, Konstantinos - Parmenion ; Vlček, Jiří (advisor) ; Zimčíková, Eva (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Kralove Department of Social and Clinical Pharmacy The analysis of pharmacotherapy in patients suffering from hyperlipidemia (Diploma Thesis) Mentor of Diploma Thesis Prof. PharmDr. Jiří Vlček, Ph.D. Mavrovouniotis Konstantinos- Parmenion Hradec Králové 2015 ABSTRACT ENGLISH The analysis of pharmacotherapy in patients suffering from hyperlipidemia Mavrovouniotis Konstantinos Mentor: Prof. Dr. Jiří Vlček, CSc. Introduction: Hyperlipidemia is a serious condition whereby the blood levels of lipids, cholesterol and triglycerides are abnormally elevated. This condition is generally asymptomatic but may lead to atherosclerotic heart disease and other types of cardiovascular pathology if not treated effectively. Various risk factors can affect the onset and severity of hyperlipidemia and those include genetic predisposition, hypertension, diabetes mellitus, obesity, poor diet, lack of regular exercise, smoking etc. Measurement and monitoring of blood levels of triglycerides, cholesterol and lipoproteins can be used as prevention method for assessing the risk for an individual to develop hyperlipidemia. Once a patient is diagnosed with the condition several approaches exist for the treatment. The main goal of the treatment is to reduce the risk of...
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Preliminary analysis of drug adherence of patient suffering with ulcerative colitis
Tsianou, Konstantina ; Vlček, Jiří (advisor) ; Ládová, Kateřina (referee)
PRΕLIMINARY ANALYSIS OF DRUG ADHERENCE OF PATIENTS WITH ULCERATIVE COLITIS Author: Konstantina Tsianou Tutor: Prof. Jiri Vlcek Department of Social and Clinical Pharmacy, Faculty of Hradec Kralove, Charles University in Prague, Czech Republic Aim of diploma thesis: To investigate the role of the beliefs of patients suffering with Ulcerative Colitis about medicines according to age group (group 1: age between 20-45 years old versus group 2: age between 46-65 years old). The study employs the Belief about Medicine Questionnaire to measure the adherence of patients with Ulcerative Colitis in Greece. Method: This study was conducted using the Greek version of the BMQ that has been translated from English into Greek language by a professional bilingual translator and then translated back into English by a native English speaker in a previous study. Results: Our study is resulted to the lowest accepting belief group ratio (12.8%) along with the highest results for ambivalent and indifferent belief group ratios (31.2% and 40%, respectively). Conclusion: The Greek version of the Beliefs about Medicines Questionnaire presented satisfactory psychometric/measurement properties indicating its reliability for use in patients with IBD who receive care in an outpatient hospital clinic. The BMQ is a useful tool...
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Dosage errors in psychiatrically diagnosed patients
Hofmanová, Tereza ; Vlček, Jiří (advisor) ; Tůma, Ivan (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Social and Clinical Pharmacy Candidate: Mgr. Tereza Hofmanová Consultant: prof. RNDr. Jiří Vlček, CSc. Title of Thesis: Dosage errors in psychiatrically diagnosed patients The aim was to capture, evaluate and statistically process the pharmaceutical misconduct of the psychiatrically ill patients. From the available documentation (D-courses), I analysed the complete drug therapies for 137 patients (59 males and 78 females) hospitalized in The Psychiatric hospital in Opava, 29.10. -1.11.2013, which was approx 15,75% of the total amount of patients. Patients were diagnosed according to ICD-10 disease according to F00- F69 and G20, G308. All patients were logged polypharmacotherapy, where each patient was treated with 2 or more drugs, the maximum quantity of drugs per person was 12. On average, the amount of drugs per patient was 6.4. The most commonly represented by the drugs belonged to antipsychotics. Used antipsychotic medications have the potential to cause a number of adverse effects as extrapyramidal symptoms, QT-interval, hyperprolactinaemia and induction of metabolic syndrome. To determine drug interactions there have been used three different programs; Infopharm ©, Micromedex ® and Drugs.com. Each has seen a...
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Individualized pharmacokinetically guided dosage adjustment of fluorouracil using population pharmacokinetic modeling
Čechlovský, David ; Vlček, Jiří (advisor) ; Pávek, Petr (referee)
vii ABSTRACT David Čechlovský‡ , Stefanie Kraff*, Ulrich Jaehde* *Institute of Pharmacy, Clinical Pharmacy, University of Bonn, Germany ‡ Department of social and clinical pharmacy, Faculty of pharmacy in Hradec Králové, Charles University in Prague Title of diploma thesis: Individualized pharmacokinetically guided dosage adjustment of fluorouracil (5-FU) using population pharmacokinetic modelling. Objectives: To develop a method to increase the efficacy and tolerability of fluorouracil (5-FU) with pharmacokinetically-guided dose adjustment based on a target AUC. Methods: Blood samples were collected from 90 patients with the diagnosis of colorectal carcinoma treated with fluorouracil (5-FU) administered at various infusion durations. Several versions of compartmental pharmacokinetic models were fitted to the plasma concentration data, using nonlinear mixed effect modelling (NONMEM). Different error models were evaluated. The potential effect of patient covariates was evaluated using a stepwise method. Model evaluation was performed by using the bootstrap method. Results: The one-compartment linear model was chosen as a base model as it was successful in fitting to the data collected..The final model contained Additive Residual Error. A covariate BSA>CL and IIV on CL were significantly correlated to the...
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Patient Perspective of Medication Information Desired
Kalaitzidis, Panagiotis ; Vlček, Jiří (advisor) ; Zimčíková, Eva (referee)
Title: Patient perspective of medication information desired Student: Kalaitzidis Panagiotis Tutor: Jiri Vlcek Department of Social and Clinical Pharmacy, Charles University in Prague, Faculty of Pharmacy in Hradec Králové Background: Even from the decade of 1970, patients wanted more information about drugs and did not want to be so depended on the information the physician provided them. Today patients are more than ever informed about their disease and the available and appropriate treatment, due to the high volume of information that can be acquired through the Internet. The traditional role of pharmacists was the provision of medicines to the population. However, nowadays, this role has been changed so as to include other tasks, such as management of prescribed medicines, and promotion of health, since pharmacists can serve as a source of expertise knowledge to the customers. Due to the fact that there is no relevant research for the case of Greek patients, this pilot research could help to fill this gap, by trying to find out what kind of information patients want to know about medicines in several pharmacies in Greece. Aim: The aim of this research is to examine what kind of information patients want related to medicines. More precisely, this research will try to identify the type of...
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Analysis of Selected Determinants of Drug Policy in the Czech Republic
Kostřiba, Jan ; Vlček, Jiří (advisor) ; Foltán, Viliam (referee) ; Suchopár, Josef (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Kralove Department of Social and Clinical Pharmacy Candidate Mgr. Jan Kostriba Supervisor prof. RNDr. Jiri Vlcek, CSc. Title of Doctoral Thesis Analysis of Selected Determinants of Drug Policy in the Czech Republic Introduction: Drug policy as part of health policy is an important factor affecting the efficiency of the health care system. Interest for the government is to realize the consump- tion of drugs in quantities which seeks to optimize the health of the patients. It should be avoided wasting drugs (high consumption of drugs) and deterioration of the health status of the population as a result of inadequate or obsolete treatment (low consumption of medicines). The aim of drug policy is to ensure safe, effective and quality medicines and to ensure optimal and accessible health care to people when required using limited funds. Objectives: The main purpose of this thesis was to analyze the selected determinants of drug policy in the Czech Republic. Attention was especially focused on analyzing the relationships between drug policy, consumption of medicines and health services and the behavior of individuals within the health care system. Other aim of the thesis was to ana- lyze the attitudes and opinions of Czech citizens on selected...
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Regulation and Safety of Non-prescription Medicines
Kopečná, Eva ; Vlček, Jiří (advisor) ; Býma, Svatopluk (referee) ; Kolář, Jozef (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Kralove Department of Social and Clinical Pharmacy Candidate: Eva Kopecna, M.D., MSc. Supervisor: Prof. RNDr. Jiri Vlcek, CSc. Title of dissertation: Regulation and safety of non-prescription medicines REGULATION AND SAFETY OF NON-PRESCRIPTION MEDICINES INTRODUCTION Non - prescription medicines (NPM) have become a major pillar of healthcare systems. Individual countries apply their politics of health care by implementation of legislation and rules which govern entry and access of NPM to the market. Among the main stakeholders who play an important role in regulation and safety of NPM in the Czech Republic (CZ) are the Government, Ministries, State Institute for Drug Control (SIDC), manufacturers and distributors, associations of manufacturers and consumers, healthcare professionals, and finally consumers. OBJECTIVES The aim of the theoretical part of our research was analysis of the legislative framework for NPM in CZ and to assess if the current legislation and educational environment for NPM can ensure safety of patients in their self-medication with NPM. METHODS For the theoretical part literature and internet research reviews have been conducted. The experimental part comprised of three studies analysing relations and behaviour of...
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ASSESSMENT OF POTENTIAL DRUG INTERACTIONS IN TWO INPATIENT WARDS IN UNIVERSITY HOSPITAL IN HRADEC KRÁLOVÉ
Maříková, Martina ; Vlček, Jiří (advisor) ; Macek, Karel (referee)
! ASSESSMENT OF POTENTIAL DRUG INTERACTIONS IN TWO INPATIENT WARDS IN UNIVERSITY HOSPITAL IN HRADEC KRÁLOVÉ Author: Maříková M.* Tutor: Vlček J.** *Clinical Pharmacy Department University Hospital Hradec Králové **Social and Clinical Pharmacy Department, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, The Czech Republic Keywords: drug interactions, clinical pharmacist, drug-related problems, geriatric patients, intensive care Background: Medicine and pharmacy are two different but related disciplines that complement, overlap and need each other. The first work, which has looked at medication errors was published in the nineties of the 20th century by the American Institute of Medicine "To Err is Human: Building a Safer Health System's" issued in November 1999. The report is based on analysis of several different studies, concluding that 44.000 to 98.000 people die each year because of preventable drug errors. In comparison, fewer than 50.000 people died from Alzheimer's disease and 17.000 died of illicit drug use in the same year. Each administration of the drug to the patient is a kind of experiment, which rely on available population data of pharmacokinetic and pharmacodynamic properties of drugs. The same situation is in a topic of drug interactions. Number of drugs in use...
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Hypertension and Nutrition: Fat-soluble Vitamins A, D and E
Weber, Jakub ; Vlček, Jiří (advisor) ; Hronek, Miloslav (referee)
Hypertension and nutrition: Fat-soluble vitamins A, D and E Weber J1 , Vlcek J1 , Suarez-Varella MM2 1 Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Czech Republic 2 Department of Preventive Medicine and Public Health, Faculty of Pharmacy, University of Valencia, Spain Arterial hypertension (AH) is a disease affecting population globally, and thus considered as a problem of public health and socioeconomic. Studies are trying to identify the connection between diet and the prevalence of arterial hypertension. Objective of the study was to determine possible association between an occurrence of AH and fat-soluble vitamins A, D and E intake. The nested, case-control population study investigation was grounded on database from the Spanish Hortega study, and performed on a random sample of 1,514 people (50.3 % women, 49.7 % men). From this sample we selected those aged ≥ 40 years old and untreated for hypertension and divided them into two groups: non-hypertensive (n = 429; 63.6 %) (controls), and newly diagnosed AH (n = 246; 36.4 %) (cases). Biochemical and anthropometric measurements, data on dietary intakes, education, socioeconomic status, place of residence, health habits, comorbidities, consumption of alcohol and tobacco were used for our...
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Health Economy and Outcomes Research in the Health Technology Assessment in the Czech Republic
Klimeš, Jiří ; Vlček, Jiří (advisor) ; Foltán, Viliam (referee) ; Švihovec, Jan (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Candidate Jiří Klimeš, PharmD Supervisor Prof. RNDr. Jiří Vlček, CSc.; MUDr. Tomáš Doležal, PhD (consultant) Title of Doctoral Thesis Health Economy and Outcomes Research in the Health Technology Assessment in the Czech Republic The aim of PhD thesis was to present on practical examples of cost-of-illness (COI), cost- effectiveness (CEA), cost-utility (CUA) and outcomes research analyses their application within current HTA (Health Technology Assessment) process of drug technologies in the Czech Republic. HTA cover complex assessment of medicinal technologies/ interventions in terms of relative effectiveness, safety, health economic aspects (cost-effectiveness and budget impact) and ethical, social and legal aspects. It was presented a methodology of COI studies and their practical application (as the inputs) into CEA, CUA analyses within selected diseases - rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Moreover, it was presented concept of Markov cohort models used in CEA, CUA analyses in area of cardiovascular diseases, post-transplantation care, intensive care medicine and therapy of dementia. Within the CUA, it was interpreted a Probabilistic Sensitivity Analysis in...
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