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Metaphors and New Dictionaries of Contemporary Czech Poetry
STANĚK, Libor
The presented dissertation will focus, through neo-pragmatic and post-analytic interpretation, on the discussed discourse of current domestic lyric poetry which is delimited by the period from the revolutionary year of 1989 to the present day. Based on this theoretical background, which will be primarily explained in the methodological part, we will perceive the mentioned literary territory as a certain playing field with specifically defined rules. The work will try to find within the scope of these rules a certain type of successful metaphors (for example "environmental lyric poetry", "conceptual writing", "millennial poetry") and vocabularies connected to them including the speech strategies initiating the new notion apparatus of current Czech poetry. The concept of metaphor will be treated in this work according to the theory of Donald Davidson who comes with an opinion that metaphor does not have any particular cognitive content but it is merely a language game requiring rather an appreciation than clarification. In connection to this theory, the study will try to evaluate the pragmatic approach of Richard Rorty, particularly his ideas about the randomness of language. These ideas will also be an important method on which basis we will examine the presented poetic material. The main merit of this dissertation is five case studies from the already mentioned time period which by means of theoretical postulates mentioned above focus on the interpretation of our delimited poetic field in which we will try to talk about successful metaphors generating new productive vocabularies maintaining the flow of speech on the topic of current Czech poetry.
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Molecular analysis of head and neck carcinomas associated with HPV infection
Glendová, Kristýna ; Staněk, Libor (advisor) ; Tachezy, Ruth (referee)
Head and neck cancers (HNSCC) are highly heterogeneous disease, results from two major carcinogens - tobacco and/or alcohol, or HR HPV infection. This thesis was based on 60 biopsies of head and neck tumours embedded into paraffin after histological verification. HPV infection, including particular types was monitored in different HNSCC regions by multiplex qPCR. Subsequent IHC demonstrated expression of p16INK4A and p53 as a possible diagnostic biomarker. Based on the information, patients with HNSCC can benefit from antiEGFR therapy by Cetuximab, but so far without defined predictors, the analysis of point mutations of Ras gene family (Kras, Nras) and Braf gene was performed. These mutations were monitored as potential predictive biomarkers, in correlation with gender, age and other risk factors. For all statistical processing the Chi-x2 test was used. Key words: Head and neck cancers, biopsy, HPV types, PCR, p16INK4A, p53, molecular predictors, Kras, Nras, Braf
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Parishes of the Volyně vicariate and their functioning in the second half of 19th century and first half of the 20th century
STANĚK, Libor
This thesis deals with history of the Volyně vicariate, focusing on the second half of the 19th century and first half of the 20th century. The thesis is divided into three major chapters which describe history of Volyně vicariate from various points of view. Chapter 1 is dedicated to archival sources which were used to obtain data for the purpose of this thesis. Archival collections of parish offices or vicar offices are introduced in this chapter, as well as wide range of usage of district office´s archival resources. All of these may be used as a source of knowledge on ecclesiastical administration. Beside this, three types of archival documents are analysed and described in this chapter - parish chronicles, visitation documents of canonical visitations, inventory of church and parish property. Chapter 2 aims to depict both movable assets and real estate in the Volyně vicariate´s parishes. Building development and reconstructions of churches and parishes in the Volyně vicariate are described in this chapter as well as equipment of churches, such as items made of metal, choir robes, bells and organs. Chapter 3 deals with clerics of the Volyně vicariate. The objective of this chapter is to introduce variedness of the parish priest´s work, duties of a chaplain and accustom of both clergymen. Duties of vicar office are also defined and specified in this chapter. The thesis also contains introduction, conclusion, bibliography, reference list and the concise history of the Volyně vicariate. At the very end of this thesis there are charts and graphs making particular chapters complete.
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The cognitive role of metaphor in post-structuralist epoche
STANĚK, Libor
Diplomová práce si klade za cíl analyzovat pojem metafory po etablování poststrukturalistického diskurzu, zvláště dekonstrukce. Student se pokusí zodpovědět otázky: co je literární prostor, zda existují jeho hranice vůči referenční sféře řeči a lze-li prokázat kognitivní funkci metafory.
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Molecular analysis of head and neck carcinomas associated with HPV infection
Glendová, Kristýna ; Staněk, Libor (advisor) ; Tachezy, Ruth (referee)
Head and neck cancers (HNSCC) are highly heterogeneous disease, results from two major carcinogens - tobacco and/or alcohol, or HR HPV infection. This thesis was based on 60 biopsies of head and neck tumours embedded into paraffin after histological verification. HPV infection, including particular types was monitored in different HNSCC regions by multiplex qPCR. Subsequent IHC demonstrated expression of p16INK4A and p53 as a possible diagnostic biomarker. Based on the information, patients with HNSCC can benefit from antiEGFR therapy by Cetuximab, but so far without defined predictors, the analysis of point mutations of Ras gene family (Kras, Nras) and Braf gene was performed. These mutations were monitored as potential predictive biomarkers, in correlation with gender, age and other risk factors. For all statistical processing the Chi-x2 test was used. Key words: Head and neck cancers, biopsy, HPV types, PCR, p16INK4A, p53, molecular predictors, Kras, Nras, Braf
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Methods of Molecular Biology in Predictive Diagnostics of Her/neu in Stomach Cancer
Důra, Miroslav ; Staněk, Libor (advisor) ; Gemperle, Jakub (referee)
Stomach cancer is a malignant neoplastic disease, which is caused by malignant transformation of the gastric mucosal epithelium. Elderly patients are more frequently affected, the majority of the patients are males. Stomach cancer has some typical features like minor symptomatology and early metastasis founding. Nowadays, a mild decrease of incidence is registered. Treatment of stomach cancer depends on its location and stage. Because of its relative chemo- and radioresistance, surgical resection is the only one potentially curable method, although there is high number of recurrences. An amplification and overexpression of HER2 receptor is detected in approximately 10 - 20 % patients with stomach cancer. This overexpression correlates with worse prognosis of disease. Treatment with a monoclonal antibody named trastuzumab, Herceptin® could significantly elongate their life. Trastuzumab is now widely and successfully used for the treatment of female patients with breast carcinoma. Detection of HER2 amplification is there needed. Treatment with trastuzumab can be useful only when HER2 positivity of tumor is determined. This determination should be made by a reliable test with sufficient sensitivity and specificity. The aim of this work is to summarize the methods of molecular biology that are used in...
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Southbohemian shepherds of poetic words
STANĚK, Libor
The presented diploma thesis maps as well as reflects poetic works of seven contemporary South Bohemian poets whose works were significant in 90s and they overlap to current times. To certain extent these poets stand unjustly on the periphery of reader's and critic´s perception of the Czech literature. Namely the poetic works of Vít Erban, Roman Szpuka, František Klišík, Jiří Staněk, Radek Štěpánek, Jan Frolík and David Jan Žák. Besides the analysis of their individual collections the thesis outlines partial poetical universality of mentioned authors. In methodological part of the work the author briefly explains the historical development of hermeneutics. Then he puts this interpretational method and the theory of reception into the confrontational scope with interpretational tendencies in work of Roland Barthese and Susan Sontag. The real picture of paradigm of contemporary literary theory is determined on the resulted premises of these explanatory. The diploma thesis also contains a brief explanation of current Czech poetry. This chapter serves as demarcation of certain literary context in which the collections of the South Bohemian poets emerge.
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Literary Work of Ladislav Klima
STANĚK, Libor
The aim of this Bachelor work is to introduce literary work of Ladislav Klíma. The theoretical part of this work is concisely describing the pragmatic factor of the language. The most important point of this issue is explained by Austin's theory of speech acts. The practical part is dedicated to Klíma's philosophical thoughts, which comes to confrontation or contradiction with other European philosophy. What follows, is Klíma's activity in the Czech Republic in which we can find him as an original and timeless writer. Next chapters are concentratedon Klíma's historical context, expressive poetics and his prosaic work which hasn't met with a success. The final chapter shows us Klíma's extraordinary worldview and internationality of his work.
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Jaromír Malý the journalist and regionalist
STANĚK, Libor
This thesis, called "Jaromír Malý the journalist and regionalist" deals with this remarkable person comming from the southern Bohemia who lived from 1885 to 1955. The thesis describes his life story and focuses on its significance. The thesis is divided into nine chapters. The first of them brings a summary of basic literature dealing with Jaromír Malý and concentrates on particular titles and studies denoted to South Bohemian regionalism. The second chapter focuses on Jaromír Malý´s life story. It depicts his studies as a term of his life and subsequent carrier in Prague, as well as relationship to his family and wife particularly. This chapter includes an analysis of letters sent by Jaromír Malý from concentration camps in Germany, in which he forcibly resided. The third chapter aims to describe his journalistic work and brings an analysis of his work done for Progressive students magazine and Progressive revue. The fourth chapter endeavours to introduce Jaromír Malý´s work in periodicals, especially the work for a local magazine Otavan. The fifth chapter is focused on a local club Prácheň, one of which founders Jaromír Malý was. In the sixth chapter Jaromír Malý´s opinion on a role of the southern Bohemia in the czech countries is given. The seventh chapter brings a description of so called cultural world of Jaromír Malý. On the basis of his archival fund which passed down fortunately, many important persons he met or kept in touch are mentioned. Beside this, the chapter brings a basic summary of his participation in cultural events and membership in various societies. The last but one chapter shows Jaromír Malý´s most favourite interest, i.e. collecting ex libris. The last chapter summarizes significance of Jaromír Malý. At the end of the thesis, there is a list of explored literature and a list of attachements. The attachments are composed of list of articles which Jaromír Malý wrote for respective magazines, list of his studies and papers that were issued separately, list of the most important dates connected to Jaromír Malý and his life, and pictures as well. In these pictures, Jaromír Malý is depicted in various stages of his life. There are also his birth certificate, school reports, invitations to cultural events, ex libris, Jaromír Malý´s death notification and several pieces of correspondence with his friends and family.
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