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Multivalentní glykokonjugáty ve studiu interakce lektinových receptorů NK/NKT buněk
Vannucci, Luca ; Pospíšil, Miloslav ; Rossmann, Pavel ; Chernyavskiy, Oleksandr ; Kubínová, Lucie ; Křen, Vladimír ; Luptovcová, Martina ; Svoboda, Jan ; Kuldová, Markéta ; Bezouška, Karel ; Fišerová, Anna
The events following the administration of GN8 in vitro, in vivo and ex vivo, lead to increased expression of CD69. The CD69-dependent IFNg production is modulated by co-activation of NKG2D and Ly49 receptors. Glycodendrimers can assist the dissection of activation network of NK/NKT cell lectin-like receptors in rat and murine models
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Multivalentní glykomika v imunoterapii experimentálních nádorů
Vannucci, Luca ; Pospíšil, Miloslav ; Krist, Pavel ; Křen, Vladimír ; Huliková, Katarína ; Luptovcová, Martina ; Svoboda, Jan ; Kuldová, Markéta ; Bezouška, Karel ; Rossmann, Pavel ; Difato, Francesco ; Mosca, F. ; Fišerová, Anna
Lectin-like receptors can modulate the cytotoxic, regulatory and dendritic cell responses by their interactions. GN8 multivalent glycoconjugates are able to internalize inside and activate NKR-P1 positive cells inducing production of IFN-gamma and expression of CD69. The final effect is a modulation of anticancer immunity with reduction of cancer growth
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Interakce glycodendrimérů s nádorovým mikroprostředím
Pospíšil, Miloslav ; Vannucci, Luca ; Luptovcová, Martina ; Svoboda, Jan ; Huliková, Katarína ; Kuldová, Miloslava ; Bezouška, Karel ; Krist, Pavel ; Pešta, M. ; Fišerová, Anna
Potentiation of immunological parameters by multivalent glycodendrimers (PAMAM-GlcNAc8) against experimental mouse melanoma and rat colon or glioma cancer. PAMAM –GlcNAc8 induce biological effects at different levels of cancer microenvironmental components and concern both, effector and cancer cells
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