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A Study of the Properties of Compacts from silicified microcrystalline celluloses.
Nováková, Petra ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
V práci je studována pevnost tablet v tahu a doba rozpadu výlisků ze silicifikovaných mikrokrystalických celulos, Prosolv SMCC 90 a Prosolv HD 90, v závislosti na lisovací síle, přídavku dvou typů mazadel a dvou léčivých látek. Mazadla byla stearan hořečnatý a stearylfumarát sodný v koncentraci 0,5%, aktivní látky kyselina askorbová a acetylsalicylová v koncentraci 50%. Prosolv SMCC 90 byl lépe lisovatelný než Prosolv HD 90; výlisky měly vyšší pevnost a ta se zvyšovala s lisovací silou. Prosolv HD 90 byl více citlivý na přídavek mazadel a větší pokles pevnosti byl zaznamenán v přítomnosti stearylfumarátu sodného. Vliv mazadel na pevnost tablet v přítomnosti léčivých látek nebyla stejná. Doba rozpadu výlisků z Prosolvu HD 90 bez i s mazadly byla kratší než z Prosolvu SMCC 90 a zvyšovala se s rostoucí lisovací silou. Doba rozpadu se prodloužila přídavkem mazadel a významně byla zkrácena přídavkem léčivých látek. Výlisky s kyselinou askorbovou měly kratší dobu rozpadu než s kyselinou acetylsalicylovou a doba rozpadu nebyla výrazně ovlivněna přítomností mazadel.
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Osmolality of parenteral preparations. Parenteral mixtures 1.
Bouallagui, Veronika ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of: Department of Pharmaceutical Technology Consultant: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Veronika Bouallagui Title of Thesis: Osmolality of parenteral preparations. Parenteral mixtures 1. In this work, density and osmolality of isotonic solutions of sodium chloride and glucose and their mixtures was measured in the molal and / or molar concentration, respectively. Osmolality was directly proportional to the increasing concentration of substance, but this is true only for solutions themselves substances; osmolality was affected by the ratio of sodium chloride and glucose in mixtures. The density of the solutions was measured at 20řC and 25řC, the average density at 20řC was used for the conversion of molality to molarity and vice versa, to estimate the osmolarity and to estimate the partial specific volume Vg (ml/g) and molal volume Vmol (ml/mol) of the solute. Partial specific volume and molal volume of glucose not relate directly to concentration of substance while decreased for sodium chloride with decreasing concentration of substance. Resulting value Vg and Vmol for mixtures of both compounds were affected by the concentration and the ratio of the two components in the mixture. Out of the three methods...
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A study of the properties of tablets made of directly compressible isomalt.
Pavlasová, Veronika ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
A study of the properties of tablets made of directly compressible isomalt. Summary The thesis deals with the study of properties of tablets from two types of directly compressible isomalt - namely galenIQTM 720 and galenIQTM 721. The focus of the study was given to the dependence of tensile strenght and disintegration time of the tablets, both on the compression force, the addition of lubricants, namely magnesium stearate and sodium stearyl fumarate (Pruv) with concentrations 0,5% and 1%, and a 50% addition of model active intgredients, namely ascorbic acid and acetylsalicylic acid. The compression forces were used 6, 8 and 10 kN, tablets containing drugs were compressed only with a force of 10 kN. The tensile streght of tablets from both substances increased with increasing compression force, the presence of lubricants did not result any decrease in the strenght. The disintegration time of tablets was longer with substance galenIQTM 720, it was prolonged by lubricants and increased with increasing compression force for both substances. The presence of drugs decreased the tensile strenght, tablets containing acetylsalicylic acid shown higher tensile strenght. For both drugs was not significant difference in the context of the type of isomalt or lubricants. The disintegration time of tablets was shorter...
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A study of the compaction process and the properties of tablets from different types of calcium hydrogen phosphate.
Koryťáková, Lenka ; Mužíková, Jitka (advisor) ; Svačinová, Petra (referee)
The thesis evaluates anhydrous and dihydrate calcium hydrogen phosphate from the view point of the tensile strength, disintegration time of tablets depending on the compression force. Two firm products - Anhydrous Emcompress® and Di-Cafos® A 60 are used as anhydrate and Emcompress® is used as dihydrate. A compression force together with lubricants (magnesium stearate, sodium stearyl fumarate) and an addition of microcrystalline cellulose (Vivapur® 102) are the influential factors. In addition to the characteristics of tablets, the energy balance of compression is also evaluated. Used compression forces were 12, 16 and 20 kN. The compression force 12 kN was used for the mixtures containing Vivapur® 102. Total energy of compression, energy for friction and energy accumulated by tablet after compression increased with compression force. The highest values were at Anhydrous Emcompress® , an addition Vivapur® 102 increased these values. There weren't more significant differences among the values of decompression energy. Plasticity decreased with the growing compression force, the highest values were at Anhydrous Emcompress® , Vivapur® 102 increased that. Tensile strength increased with compression force, Emcompress® provided the strongest tablets, Di-Cafos® A 60 provided at least strong tablets. Vivapur...
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A study of the compaction process and the properties of tablets made of agglomerated and granulated lactose
Neprašová, Marie ; Mužíková, Jitka (advisor) ; Ondrejček, Pavel (referee)
The thesis studied tensile strength, disintegration time of tablets and energy profile of compression of agglomerated lactose Tablettose® 80 and of granulated lactose SuperTab® 30GR. Tested parameters were studied depending on compression force, addition of two concentrations of the lubricant magnesium stearate (0.5 and 1%) and 25% microcrystalline cellulose Microcel® MC-200. The tablets were compressed using the material testing machine T1 - FRO 50 TH.A1K Zwick/Roell. Used compression forces were 11, 13 and 15 kN, in the case of mixtures with Microcel® MC-200 11 kN. Tensile strength of tablets increased with compression force at both lactoses and it was higher in the case of mixtures with SuperTab® 30GR. Magnesium stearate decreased the tensile strength of tablets from Tablettose® 80 for all compression forces. Addition Microcel® MC-200 increased the tensile strength of tablets from both lactoses, more in the case of Tablettose® 80. Disintegration time of tablets increased with compression force. Higher concentrations of magnesium stearate in tablets increased disintegration time. Comparison of disintegration time of tablets from both lactoses depended on concentration of magnesium stearate. Addition of Microcel® MC-200 significantly shortened disintegration time of tablets in both lactoses. The...
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Osmolality of Parenteral Preparations. Phosphates 1.
Pavelková, Martina ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of: Department of Pharmaceutical Technology Consultant: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Mgr. Martina Pavelková Title of Thesis: Osmolality of parenteral preparations. Phosphates 1. The aim of this work was to prepare aqueous solutions of disodium hydrogen phosphate dodecahydrate, in the concentration range from 0.01 to 0.3 mol/kg respectively mol/l and to measure their density and osmolality. Density with increasing temperature in the range from 15řC to 40řC decreased nonlinearly; the relationship was described by quadratic regression equations. At constant temperature, the density of disodium hydrogen phosphate dodecahydrate, is directly proportional to the concentration. Osmolality increases with molal and molar concentration increases, the dependence was described by quadratic regression equation with a coefficient of determination 0.8759 for molal solutions and 0.8591 for molar solutions. From the measured values of osmolality was determined molal osmotic coefficient, whose values decrease when a concentration of the solution increased. The average density value of each of the solutions at temperature of 25řC were used for the mutual conversion between molality and molarity and to estimate the...
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Osmolality of parenteral preparations . Phosphates
Černá, Veronika ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Candidate Mgr. Veronika Černá Consultant Doc. PharmDr. Zdenka Šklubalová, PhD. Title of Thesis Osmolality of parenteral preparations. Phosphates. The aim of this work was to prepare a series of solutions of sodium acid phosphate dihydrate at concentrations from 20 to 1000 mg/kg or mmol/l. Density at temperatures 15, 20, 25, 30, 35 and 40řC and osmolality of all solutions was measured. A non-linear relationship was detected between the solution density and temperature. The relationship of osmolality on molal and molar concentration of substance was described by a quadratic equation. The density of solutions at 25řC were performed for conversion of molal to molar concentration of the solution and vice versa. The molal osmotic coefficient was determined from the solution osmolality, whose value declines at increasing concentrations of the solute. From the methods of osmolarity estimation presented in USP, the most accurate one employing a partial specific volume of the solute was detected for sodium acid phosphate.
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Osmolality of parenteral preparations. Potassium phosphate.
Pavelková, Martina ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of: Department of Pharmaceutical Technology Consultant: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Martina Pavelková Title of Thesis: Osmolality of parenteral preparations. Potassium phosphate. In this work the density and osmolality of aqueous solutions of potassium dihydrogen phosphate was measured in the a concentration range from 0.02 to 1.0 mol/kg and/or mol/l, respectively. When increasing the temperature in the a range from 15řC to 40řC density decreased but the relationship was not linear. At constant temperature the density was directly proportional to the concentration of solution. The dependence between concentration and osmolality was described by a quadratic regression with the coefficient of determination 0.9997 for molal and molar solutions. The solution density at 25řC was used for mutual conversion between the molarity and molality and for estimation of the osmolarity in accordance to USP. Out of three studied methods the most accurate method of osmolarity estimation was the method utilizing the partial specific volume of the solute, which slightly increasinged when a concentration of the solution increased. For potassium dihydrogen phosphate, the mean partical specific volume of 0.31 ml/g could be...
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A study of a novel dry binder composed of α-lactose monohydrate, microcrystalline cellulose and corn starch
Srbová, Alena ; Mužíková, Jitka (advisor) ; Svačinová, Petra (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department Pharmaceutical Technology Candidate Mgr. Alena Srbová Consultant PharmDr. Jitka Mužíková, Ph.D. Title of the Thesis A study of a novel dry binder composed of α-lactose monohydrate, microcrystalline cellulose and corn starch This paper deals with a study of the novel dry binder Combilac® , which contains 70 % of α-lactose monohydrate, 20 % of microcrystalline cellulose and 10 % of native starch. These tests include flow properties, compressibility, lubricant sensitivity, tensile strenght and disintegration time of tablets. Compressibility is evaluated by means of the energy profile of compression proces and tablet strenght. The above-mentioned parameters are also evaluated in the physical mixture of α-lactose monohydrate, microcrystalline cellulose and native corn starch and results are compared. Combilac® and physical mixture cannot be compressed without lubricants due to high friction and sticking to the matrix. Combilac® shows much better flowability than the physical mixture of the used dry binders, its compressibility is better and the total energy is higher. Tablets possess a higher tensile strength and higher lubricant sensitivity. Disintegration time of Combilac® tablets is comparable with the disintegration time...
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Energy Evaluation of Compression Process of Tablets from the New Type of Silicified Microcrystalline Cellulose
Mašatová, Pavlína ; Mužíková, Jitka (advisor) ; Šklubalová, Zdeňka (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical technology Candidate Mgr. Pavlína Mašatová Consultant PharmDr. Jitka Mužíková, Ph.D. Title of Thesis Energy evaluation of compression process of tablets from the new type of silicified microcrystalline cellulose This thesis studied the energy evaluation of compaction process from co-processed dry binder Prosolv EASYtab and the results were compared with Prosolv SMCC 90 and the physical mixtures of Prosolv SMCC 90 with Explotab (in concentration 1% or 1,5%) and Pruv (in concentration 0,5% or 1%). The mixtures with the active ingredients were evaluated too, specifically with ascorbic acid and acetylsalicylic acid. Tablets were compressed using material tableting machine T1-FRO 50 Th.A1K Zwick/Roell and used compression forces were 3, 3,5 and 4 kN, in the case of mixtures with drugs 4 kN. Computer program testXpert V 9.01 shown and drawn during the compression graphical records of "force-displacement" and quantified individual types of energy and plasticity. From comparison of substances results, that Prosolv EASYtab had the lowest total energy of compression (Emax) and the plasticity in all compression forces. The values of the total energy of compression were due to the values of energy accumulated by...
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