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LABORARTORY BRNO
Lukášová, Petra ; Joura, Ivo (referee) ; Mikulášek, David (advisor)
The designed building is situated on the corner of Milady Horákové Street and Koliště Street. The building site is related with a nearby green circuit, where public buildings are located. The design presents the comprehensive building solution at a corner site. The most dominant object is the gallery building which continues into the office building with workrooms and studios and the apartment building. The facade of the gallery is affected by an interior illumination, that is why longitudinal windows covered by milk-glass scales are used and the scale structure is used for the entire façade made of golden plate. Fascades of other buildings are sober and proportional to the function of the buildings.
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CITY HALL - RES PUBLICA, The administrative center of the district of Brno-sever
Lukášová, Petra ; Rudiš, Viktor (referee) ; Oplatek, Jiří (advisor)
At a very attractive place of city district Černá pole which is situated close to the city centre. There are old barracks. The aim was to create a new city quarter, from this area with all the facilities ,which are necesaryly. The purpose of my master theses was to create a design of a city hall, which would be situated. The most attractive place, which have interesting and memorable position on the top of the hill. Here is a possibility to create a new centre, of city district which is a very inconsistent today. This place is also well reachable by public transport. The building is created by glass parterre and desk covered by metal mesh. The metal mesh is making a shading as well.
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Genetic causes of MODY (Maturity-Onset Diabetes of the Young)- prevalence of mutations in the MODY genes in the Czech diabetic and nondiabetic populations
Lukášová, Petra ; Bendlová, Běla (advisor) ; Gašperíková, Daniela (referee) ; Mazura, Ivan (referee)
I I a I I I I I I I I I I I I I I I I I 6. CONCLUSTONS Theaimsof ourstudywereperformed. Twelvefamilieswithunrecognizedtypeof MODYwerecotlected. Quite largecohortsof DM2patients,direct offspringof DM2patients,gestational diabeticsandsufficienttylargegroupof controlsubjectswerecompleted.Attthe probands underwenta detaitedanthropometricand biochemicalcharacterisation.Datawere filled in anelectronicdatabase. TheDNAbankwasestablishedandcompleted. For GCK gene we adopted screeningmethodsSSCP for all exons specific for B-celts(1a-10)andTGGEfor exons1a-7andwe confirmedtheirhighsensitivityandthe 100%concordanceof both methods.Resultswere consequentlyconfirmedby direct sequencingin bothdirections. We founda novelheterozygousmissensemutationV33Aand a previoustypubtished mutationE40Kin exon2 of GCK genein two differnentCzechMODYfamilies.However, ourstudydid not providethe evidenceof GCK geneas a risk genein the pathogenesis of diabetesmellitustype2 or of the gestationaldiabetesin Czechpopulationbecausewe identifiedontyone intronicmutationin a gestationaldiabeticand no differencesin the frequenciesof GCKpolymorphismsbetweenCzechdiabeticandnondiabeticpopulations. We assessedthe frequencyof commonvariant-30G>Ain B-promoterof GCK gene. Atthoughwe did not detect the higherfrequencyof minor attele A in diabetic in...
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Study of Common Pathogenetic Factors of Alzheimer Disease and Type 2 Diabetes Mellitus
Vacínová, Gabriela ; Vaňková, Markéta (advisor) ; Lukášová, Petra (referee)
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are aging-associated diseases that have rising prevalence in all industrialized countries. AD is a neurodegenerative disease characterized by progressive loss of cognitive functions. It is a complex disease which formation involves both genetic factors and environmental factors. The most important marker associated with this disease is the risk allele ε4 in APOE gene. From the latest genome-wide association study emerged another ten candidate genes. As the most significant from those genes appears the minority G allele of rs744373 polymorphism in the gene BIN1. AD is connected with many metabolic and immune disorders. To the markers of interest belongs also the new parameter visfatin which can act as a pro-inflammatory cytokine. T2DM is a chronic disease characterized by raised levels of blood glucose, which is also characterized by neurological disorders. In the case of both of these diseases can be found a large number of metabolic disorders. One of the most important disorders is insulin resistance. This thesis consists of two parts - the biochemical and genetic one. The biochemical part of the thesis studies the visfatin level in patients with AD and healthly control and studies whether visfatin is related to AD. In this part of the...
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LABORARTORY BRNO
Lukášová, Petra ; Joura, Ivo (referee) ; Mikulášek, David (advisor)
The designed building is situated on the corner of Milady Horákové Street and Koliště Street. The building site is related with a nearby green circuit, where public buildings are located. The design presents the comprehensive building solution at a corner site. The most dominant object is the gallery building which continues into the office building with workrooms and studios and the apartment building. The facade of the gallery is affected by an interior illumination, that is why longitudinal windows covered by milk-glass scales are used and the scale structure is used for the entire façade made of golden plate. Fascades of other buildings are sober and proportional to the function of the buildings.
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CITY HALL - RES PUBLICA, The administrative center of the district of Brno-sever
Lukášová, Petra ; Rudiš, Viktor (referee) ; Oplatek, Jiří (advisor)
At a very attractive place of city district Černá pole which is situated close to the city centre. There are old barracks. The aim was to create a new city quarter, from this area with all the facilities ,which are necesaryly. The purpose of my master theses was to create a design of a city hall, which would be situated. The most attractive place, which have interesting and memorable position on the top of the hill. Here is a possibility to create a new centre, of city district which is a very inconsistent today. This place is also well reachable by public transport. The building is created by glass parterre and desk covered by metal mesh. The metal mesh is making a shading as well.
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