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The pharmacotherapy of the depression
Juřičková, Markéta ; Melicharová, Ludmila (advisor) ; Vopršalová, Marie (referee)
School: Charles University in Prague Faculty: Faculty of Pharmacy in Hradec Králové Study program: Pharmacy Department: Department of pharmacology and toxicology Academic year: 2010/2011 Author: Markéta Juřičková Supervisor: PharmDr. Ludmila Melicharová Title of diploma thesis: The pharmacotherapy of the depression This diploma thesis deals with the characterization of depression including its pathophysiology, causes, symptoms, progress as well as it classifies the types of depressive disorders. The diploma thesis deals with the treatment of depression, selection of antidepressants, using of antidepressants in children and adolescents, geriatric patients and pregnant women. It further describes individual groups of antidepressants, their mechanism of action, indications, contraindications and adverse effects. The thesis evaluates benefits of pharmacotherapy in depression treatment. It also classifies and describes the most common forms of psychotherapy. It further deals with other options in depression treatment like phototherapy, electroconvulsive therapy, physical activity, repetitive transcranial mechanical stimulation, vagus nerve stimulation and deep brain stimulation. It describes their mechanisms of action, adverse effects, indications and their benefits in depression treatment, especially...
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HPLC analysis of drugs II
Juříčková, Markéta ; Sochor, Jaroslav (advisor) ; Kovaříková, Petra (referee)
HPLC ANALYSIS OF DRUGS II. Diploma thesis Markéta Juříčková Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Drug Control, Heyrovského 1203, Hradec Králové In diploma thesis the optimal condition for analytical determination of tiaprofenic acid in plasma using solid-phase microextraction (SPME) and high performance liquid chromatography (HPLC) was developed. The final analysis was performed on RP18 analytical column. The mobile phase was composed of a mixture of methanol and phosphate buffer. The flow rate of 0.7 ml/min was used. 20 µl of sample was injected on the column. Detection was performed in UV range at 306 nm. PDMS/DVB microextraction fiber was used for the isolation of tiaprofenic acid from the sample. At first tiaprofenic acid was isolated from the water solution. Recovery of the microextraction was 19.46 %. Thereafter, tiaprofenic acid was extracted from model plasma sample. Prior extraction, pH of plasma was adjusted on 2.8. Methanol was used for analyte desorption. Optimal time of sorption and desorption was also determined. Efficiency of the developed extraction was 9.74 %. Quantitative determination of tiaprofenic acid from the plasma sample was performed by calibration curve and using external standard. Key words: HPLC,...
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The pharmacotherapy of the depression
Juřičková, Markéta ; Melicharová, Ludmila (advisor) ; Vopršalová, Marie (referee)
School: Charles University in Prague Faculty: Faculty of Pharmacy in Hradec Králové Study program: Pharmacy Department: Department of pharmacology and toxicology Academic year: 2010/2011 Author: Markéta Juřičková Supervisor: PharmDr. Ludmila Melicharová Title of diploma thesis: The pharmacotherapy of the depression This diploma thesis deals with the characterization of depression including its pathophysiology, causes, symptoms, progress as well as it classifies the types of depressive disorders. The diploma thesis deals with the treatment of depression, selection of antidepressants, using of antidepressants in children and adolescents, geriatric patients and pregnant women. It further describes individual groups of antidepressants, their mechanism of action, indications, contraindications and adverse effects. The thesis evaluates benefits of pharmacotherapy in depression treatment. It also classifies and describes the most common forms of psychotherapy. It further deals with other options in depression treatment like phototherapy, electroconvulsive therapy, physical activity, repetitive transcranial mechanical stimulation, vagus nerve stimulation and deep brain stimulation. It describes their mechanisms of action, adverse effects, indications and their benefits in depression treatment, especially...
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HPLC analysis of drugs II
Juříčková, Markéta ; Kovaříková, Petra (referee) ; Sochor, Jaroslav (advisor)
HPLC ANALYSIS OF DRUGS II. Diploma thesis Markéta Juříčková Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Drug Control, Heyrovského 1203, Hradec Králové In diploma thesis the optimal condition for analytical determination of tiaprofenic acid in plasma using solid-phase microextraction (SPME) and high performance liquid chromatography (HPLC) was developed. The final analysis was performed on RP18 analytical column. The mobile phase was composed of a mixture of methanol and phosphate buffer. The flow rate of 0.7 ml/min was used. 20 µl of sample was injected on the column. Detection was performed in UV range at 306 nm. PDMS/DVB microextraction fiber was used for the isolation of tiaprofenic acid from the sample. At first tiaprofenic acid was isolated from the water solution. Recovery of the microextraction was 19.46 %. Thereafter, tiaprofenic acid was extracted from model plasma sample. Prior extraction, pH of plasma was adjusted on 2.8. Methanol was used for analyte desorption. Optimal time of sorption and desorption was also determined. Efficiency of the developed extraction was 9.74 %. Quantitative determination of tiaprofenic acid from the plasma sample was performed by calibration curve and using external standard. Key words: HPLC,...
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