|
|
Pyrazine derivatives as potential drugs V.
Horová, Anna ; Marek, Jan (advisor) ; Holas, Ondřej (referee)
Charles University in Prague, Pharmaceutical Faculty in Hradec Králové Department: Department of Pharmaceutical Chemistry and Drug Control Diplomate: Anna Horová Supervisor: PharmDr. Jan Marek, Ph.D. Title of Diploma Thesis: Pyrazine derivatives as potential drugs V. TBC is a specific world-wide infectious disease, compounded by increased migrations of people, the spread of HIV and the growth of MDR-TB, including extremely resistant strains. Precisely for the growth of MDR-TB resistant mycobacteria the work is focused on the preparation and development of other possible antituberculosis drugs (Pyrazine derivatives). Research into new medications lays emphasis on altering the effects of enzymes important for the vitality of mycobacteria. As part of my diploma thesis, pyrazine derivative modifications of clinical pyrazinamide medications were prepared. PZA is an important part of the short-term TBC treatment, having a sterile effect and the ability to work in an acidic environment and has a significant synergy with rifampicin. The small PZA molecule is a precursor to the pyrazine acid activated by pyrazinamide or nicotinamide. Hydrolysis of PZA in mycobacterial cells create Pyrazinecarboxylic acid (POA). In the experimental part, we have examined the variation molecules pyrazinamide and preparing the...
|
|
|
Pyrazine derivatives as potential drugs V.
Horová, Anna ; Marek, Jan (advisor) ; Holas, Ondřej (referee)
Charles University in Prague, Pharmaceutical Faculty in Hradec Králové Department: Department of Pharmaceutical Chemistry and Drug Control Diplomate: Anna Horová Supervisor: PharmDr. Jan Marek, Ph.D. Title of Diploma Thesis: Pyrazine derivatives as potential drugs V. TBC is a specific world-wide infectious disease, compounded by increased migrations of people, the spread of HIV and the growth of MDR-TB, including extremely resistant strains. Precisely for the growth of MDR-TB resistant mycobacteria the work is focused on the preparation and development of other possible antituberculosis drugs (Pyrazine derivatives). Research into new medications lays emphasis on altering the effects of enzymes important for the vitality of mycobacteria. As part of my diploma thesis, pyrazine derivative modifications of clinical pyrazinamide medications were prepared. PZA is an important part of the short-term TBC treatment, having a sterile effect and the ability to work in an acidic environment and has a significant synergy with rifampicin. The small PZA molecule is a precursor to the pyrazine acid activated by pyrazinamide or nicotinamide. Hydrolysis of PZA in mycobacterial cells create Pyrazinecarboxylic acid (POA). In the experimental part, we have examined the variation molecules pyrazinamide and preparing the...
|
|
|
determining Stroncia in biological matter by atomic absorption spectrometry
Horová, Anna ; Kukačka, Jiří (advisor) ; Klapková, Eva (referee)
Trace elements play an important role in human body. Thanks to the availability of modern technology, more and more attention is being paid to studying the concentrations of these elements in human tissue with respect to health disorders in people. Strontium is one of such elements. It has not yet been proved that its deficiency may cause serious health problems. However, this element is potentially toxic, especially after prolonged exposure. On the other hand, in low doses it has particularly favourable effects on the bone tissue, particularly in patients suffering from osteoporoses. This is why it has recently become one of the component used in an effective medicine - stronium ranelate - to treat osteoporoses. The aim of this theses was to introduce a method suitable for determining strontium concentrations and to determine Sr in: a) plasma and serum of patients treated with strontium ranelate b)serum of children up to the age of one year c)venous and arterial umbilical blood d)the liver tissue of laboratory rat A method of determining Sr in biological matter by means of flame and flameless AAS has been introduced. Plasmatic Sr concentrations in patients treated with strontium ranelate were found at levels from 30 g/l to 17757 g/l, urinal residue ranged from 0.17 mg/24 hour to 232 mg/24 hour. Based on...
|
guest ::
RSS feed.