National Repository of Grey Literature 7 records found  Search took 0.01 seconds. 
Morfologické změny při karcinomu tlustého střeva vyvolaném u myší azoxymethanem a natrium dextransulfátem
Klimešová, Klára ; Rossmann, Pavel ; Kverka, Miloslav ; Frolová, Lenka ; Tlaskalová, Helena
This study confirmed an important role of inflammation in colon carcinogenesis. Developing of tumors is usually closely associated with the areas of inflammation
Exprese toll-like receptorů 2 a 4 a CD14 ve střevní mukóze u pacientů s nespecifickými střevními záněty (NSZ)
Frolová, Lenka ; Drastich, P. ; Klimešová, Klára ; Rossmann, Pavel ; Tlaskalová, Helena
This study show that IBD may be associated with increased expression of TLR2 and CD14 in the intestinal epithelium of the patients
Morphological changes in developing cancer of colon in mice induced by combined administration of azoxymethane and sodium dextran sulfate
Klimešová, Klára ; Rossmann, Pavel ; Kverka, Miloslav ; Frolová, Lenka ; Tlaskalová, Helena
Early stages of carcinoma were documented by light and scanning microscopy, and by immunohistochemical proof of beta-catenin. The study documented the importance of dextran sulfate-induced colitis in the development of mucosal dysplasia and carcinoma
Toll-like receptors -2, -4 and the CD14 molecule in intestinal biopsies of patients with nonspecific intestinal inflammation
Frolová, Lenka ; Drastich, P. ; Klimešová, Klára ; Rossmann, Pavel ; Tlaskalová, Helena
Expression of TL-2 and TL-4 receptors and of their transmembranes coreceptor CD14 was detected immunohistochemically in biopsies of ileum, colon caecum and rectum of patients suffering from ulcerous colitis or Crohn´s disease. All these three were significantly enhanced in epithelial cells and macrophages of propria in inflammatory bowel disease as compared to the control samples
Slizniční imunita, střevní mikroflora a nespecifické střevní záněty
Tlaskalová, Helena ; Štěpánková, Renata ; Sokol, Dan ; Rossmann, Pavel ; Cukrowska, Božena ; Hudcovic, Tomáš ; Tučková, Ludmila ; Kozáková, Hana ; Řeháková, Zuzana ; Hrnčíř, Tomáš ; Drastich, Pavel ; Frolová, Lenka ; Powrie, F. ; Uhlig, H. ; Bland, P. W.
Etiological role of intestinal microflora and abberant function of mucosal immunity in development of inflammatory bowel disease is discussed. Animal models of human IBD are described and characterized

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