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Measurement and analysis of cardiovascular parameters
Filipová, Petra ; Smital, Lukáš (referee) ; Kratochvíla, Jiří (advisor)
This bachelor´s thesis illustrates the basic diagnostic procedures for ECG analysis in clinical practice. It contains the verification of statistical hypotheses, automatic detection of the RR intervals using three different QRS detectors and heart rate from the ECG und other analyses in time and frequency domain. The validation of detection efficiency is investigated. Heart rate variability analyses are shown in time and frequency domain too. Analyses are done in Matlab, the graphical interface in Maltab GUIDE was done too and includes all of the created functions in time and frequency domain. For the purpose of evaluation methods the real data were measured according to the created acquisition protocol.
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Batch processing of perfusometric MRI data
Filipová, Petra ; Macíček, Ondřej (referee) ; Jiřík, Radovan (advisor)
This diploma thesis deals with the DCE – MRI method (Dynamic contrast enhanced magnetic resonance imaging). Basic principle of magnetic resonance and pulse sequence is described. The diploma thesis focuses on the DCE method, especially on the description of the processing procedure by this method. Description of selected pharmacokinetic models is the part of this diploma thesis as well. Furthermore, description and realization of batch processing by PerfLab system is presented. For verifying purposes of the batch processing functionality real data were measured using created acquisition protocol, which is also part of the diploma thesis.
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Progression of endothelial dysfunction in heart in a mouse model of atherosclerosis.
Filipová, Petra ; Němečková, Ivana (advisor) ; Doleželová, Eva (referee)
Charles University in Prague, Faculty od Pharmacy in Hradec Králové Department of Biological and Medical Sciences Progression of endothelial dysfunction in heart in a mouse model of atherosclerosis Author of diploma thesis: Petra Filipová Supervisor: RNDr. Ivana Němečková, Ph.D. Backround: Atherosclerosis is a disease when atherosclerotic lesions are formed in vessels. It represents the major cause of the heart failure and stroke. The endothelial dysfunction, which has been recorded in a large number of animals, is considered one of the main causes of atherosclerosis. In our work we have focused on the detection of the endothelial dysfunction markers in the heart of the ApoE/LDLR double knock-out mouse model. Methods: We detected changes in the expression of eNOS, p-eNOS and HO-1 in two-months and eight-months old ApoE/LDLR double knock-out mice, which were fed standard chow diet. For the semiquantitative evaluation of the observed markers we used the Western blot analysis of the homogenated left ventricle. Results: According to our results there is no difference in the expression of eNOS, p-eNOS and HO-1 in the studied mouse model of atherosclerosis in relation to age. This might mean, that the endothelial dysfunction in the coronary vessels of these mice doesn't develop. However, for further...
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Progression of endothelial dysfunction in heart in a mouse model of atherosclerosis.
Filipová, Petra ; Němečková, Ivana (advisor) ; Doleželová, Eva (referee)
Charles University in Prague, Faculty od Pharmacy in Hradec Králové Department of Biological and Medical Sciences Progression of endothelial dysfunction in heart in a mouse model of atherosclerosis Author of diploma thesis: Petra Filipová Supervisor: RNDr. Ivana Němečková, Ph.D. Backround: Atherosclerosis is a disease when atherosclerotic lesions are formed in vessels. It represents the major cause of the heart failure and stroke. The endothelial dysfunction, which has been recorded in a large number of animals, is considered one of the main causes of atherosclerosis. In our work we have focused on the detection of the endothelial dysfunction markers in the heart of the ApoE/LDLR double knock-out mouse model. Methods: We detected changes in the expression of eNOS, p-eNOS and HO-1 in two-months and eight-months old ApoE/LDLR double knock-out mice, which were fed standard chow diet. For the semiquantitative evaluation of the observed markers we used the Western blot analysis of the homogenated left ventricle. Results: According to our results there is no difference in the expression of eNOS, p-eNOS and HO-1 in the studied mouse model of atherosclerosis in relation to age. This might mean, that the endothelial dysfunction in the coronary vessels of these mice doesn't develop. However, for further...
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Measurement and analysis of cardiovascular parameters
Filipová, Petra ; Smital, Lukáš (referee) ; Kratochvíla, Jiří (advisor)
This bachelor´s thesis illustrates the basic diagnostic procedures for ECG analysis in clinical practice. It contains the verification of statistical hypotheses, automatic detection of the RR intervals using three different QRS detectors and heart rate from the ECG und other analyses in time and frequency domain. The validation of detection efficiency is investigated. Heart rate variability analyses are shown in time and frequency domain too. Analyses are done in Matlab, the graphical interface in Maltab GUIDE was done too and includes all of the created functions in time and frequency domain. For the purpose of evaluation methods the real data were measured according to the created acquisition protocol.
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Batch processing of perfusometric MRI data
Filipová, Petra ; Macíček, Ondřej (referee) ; Jiřík, Radovan (advisor)
This diploma thesis deals with the DCE – MRI method (Dynamic contrast enhanced magnetic resonance imaging). Basic principle of magnetic resonance and pulse sequence is described. The diploma thesis focuses on the DCE method, especially on the description of the processing procedure by this method. Description of selected pharmacokinetic models is the part of this diploma thesis as well. Furthermore, description and realization of batch processing by PerfLab system is presented. For verifying purposes of the batch processing functionality real data were measured using created acquisition protocol, which is also part of the diploma thesis.
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Abortion for underage people - ethical context
FILIPOVÁ, Petra
FILIPOVÁ, P. Abortion for underage people ? ethical context. České Budějovice, 2013. A diploma thesis written under Faculty of Health and Social Studies, the thesis advisor Mgr. et Mgr. Ondřej Doskočil, Th.D. The diploma thesis tries to describe the issue of abortion for underage applicants and related context. This sensitive issue is regulated by the Law no 66/1986, of abortion. The thesis is divided into theoretical and practical part. The first part deals with contemporary condition of abortion for underage people in general context. The following topics are analysed in the next step: historical context of abortion in the Czech Republic, relation of abortion and medicine, justificatory reasons of abortion and ethical context of this sensitive issue. Methods of abortion are described in the following section. One of the most crucial chapters is the consent and the steps which are taken in connection with underage patients. In the research part of the thesis, the strategy of qualitative research was used, which was performed by the method of interrogation. The semistructured interview was chosen as a technique for the interrogation. The research file consisted of 5 male and 3 female doctors from gynaecological surgeries and from the women department of hospitals from different parts of the Czech Republic. The aim of the diploma thesis was to describe the recent situation of providing consent about performing abortion of underage applicants for this medical intervention; to find out and describe how male and female doctors of gynaecological surgeries and women departments of hospitals deals with the whole abortion of underage people issue as professionals but also personally. The last of the generated aims was to point out ethical context connected with the issue on the basis of new-found information. In order to reach the aims mentioned above, we used a set of questions which were focused on the abortion for underage applicants procedure and on the issue of the consent about performing this medical intervention. In the discussion chapter, the answers from the interviews are summarized and those answers are compared with available literature and they are supported with arguments. In the end, thesis which can serve as hypothesis for possible quantitative research were defined. From the research, it came out that questioned male and female doctors prefer legal aspect of medical care when deciding at the expense of ethical aspects and they also notice a conflict between legal adjustment of abortion for underage people and legal adjustment of other medical interventions connected with this age group. It also came out that laws should origin from the deep conviction of the whole society because nobody cannot be sure how he or she would act in this situation. Interviewees emphasise that an underage girl should learn how to act with responsibility. If she feels mature enough for sexual life, she should also bear all the consequences of her decision. The thesis also refers to the question of the genesis of life as modern biology proves uniqueness of an individual from the moment of conception. Outcomes of the research could be used for description of the whole situation connected with abortion for underage people, for discovering this issue and extension of laymen and professional community awareness. The research could be also useful for helping professions.
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Comparison of eating habits at students of the Faculty of Health and Social Studies
FILIPOVÁ, Petra
A theoretical part is focused on basic conceptions of alimentation, on influences affecting the nutrition and on various dietary components and their significance. Among others, this part emphasizes a proper nutrient intake and dietary guidelines. Three aims were defined in the practical part. The main objective was to determine eating habits of students from University of South Bohemia in České Budějovice, Faculty of Health and Social Studies, whether they eat in compliance with the proper daily intake of calories and nutrients. Then to find out what leads students to an incorrect diet on the basis of found values to propose a healthier way of eating. In order to achieve the defined aims I used a qualitative research, an interviewing method and a technique of a semi-structured interview with 10 students. The interviews were made in the second part of February 2011. Four days were recorded at all respondents, beginning from Sunday. After the interviews were analysed and evaluated, I found out that 9 of 10 respondents have noticeable fluctuations of the daily caloric intake. At 10 respondents I recorded an irregularity of meals, a deficiency in fruits and vegetables intake and therefore a deficiency in vitamin C. The semi-structured interviews showed that 8 of 10 students had a redundant intake of proteins which could have negative impacts on the body. A choice of food at 9 of 10 students has been determined by price. 10 students do not have any health restrictions of the food intake. The research showed that while studying at the university the eating habits at 1 student of 10 changed positively, at 2 students there was no change and at 7 students the eating habits became worse. The bachelor thesis could be used for a better orientation in the given issues which point out errors in the alimentation and it will offer an extension of awareness at the lay and professional public.
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