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The effect of temperature on the charging and discharging characteristics of lithium-ion batteries
Doleželová, Eva ; Máca, Josef (referee) ; Libich, Jiří (advisor)
This thesis deals with operation principles of lithium-ion batteries, its degradation principles, capacity fade, materials used, formats, main characteristics, development, uses and mid to high temperature behaviour. The thesis aims to study aging characteristics of commercially available lithium-ion batteries. In the practical part of the thesis, the key parameters of selected types of commercially available lithium-ion batteries were measured under normal temperature conditions. The measurement was repeated at an elevated temperature. Results were analysed and effects of different temperatures on the selected characteristics were concluded both verbally and graphically. A conclusion evaluates short-term and long-term impacts of ambient temperature on rate capability, ageing, capacity fade and longevity.
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Interactions between WLAN networks
Doleželová, Eva ; Zeman, Kryštof (referee) ; Škorpil, Vladislav (advisor)
This bachelor thesis deals with the possible interferences caused by the parallel running WLAN networks. It explains the history and subsequent development of wireless technologies and then focuses on current WLAN networks. It describes the problem of interference in WLAN networks and parameters that contribute to mutual interference. Practical part of this thesis consists of two laboratory exercises. The first task is implemented in the Riverbed program, in which a topology with three identical WLAN routers is assembled. After testing the WLAN routers, a graph describing the interference in the 2.4 GHz band is displayed, which is achieved by a suitable choice of frequency band, transmission power and channel. The second laboratory task is implemented utilizing the Iperf3 program, which is installed on three Raspberry Pi´s (RPi Zero, RPi 3, and RPi 4). Network congestion is achieved using the wifijammer script, which is installed on RPi 4. In this second laboratory task, the transmission parameters were first verified and the service was denied using the wifijammer script. For evaluation of the second laboratory task, the IEEE 802.11b and IEEE 802.11n utilizing the frequency band 2,4 GHz were chosen. For testing, the following routers were used: Mercusys, Netis, Tp-Link and Asus routers. Once the measurements were over, all the data was processed and included as charts.
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Evaluation of the Financial Situation of a Company and Proposals For Its Improvement
Doleželová, Eva ; Kristián, Petr (referee) ; Sághy Estélyi, Kristína (advisor)
The goal of the submitted thesis "Evaluation of the financial situation and proposals for its improvement" is based on economic analysis, assessment of the performance of the selected enterprises Montáže inženýrských sítí spol. s r.o. and identify the weaknesses of the company and then propose solutions to eliminate them. The first part is defined to theoretical and methodological bases of economic analysis. In the second part are then selected methods applied to a specific company. In this work are used to evaluate the economic performance of enterprises methods of financial analysis, PEST analysis, Porter’s five forces analysis and SWOT analysis. The results of the calculations is the synthetic part of the work assessed and management measures designed to improve the financial situation of the company.
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The effect of temperature on the charging and discharging characteristics of lithium-ion batteries
Doleželová, Eva ; Máca, Josef (referee) ; Libich, Jiří (advisor)
This thesis deals with operation principles of lithium-ion batteries, its degradation principles, capacity fade, materials used, formats, main characteristics, development, uses and mid to high temperature behaviour. The thesis aims to study aging characteristics of commercially available lithium-ion batteries. In the practical part of the thesis, the key parameters of selected types of commercially available lithium-ion batteries were measured under normal temperature conditions. The measurement was repeated at an elevated temperature. Results were analysed and effects of different temperatures on the selected characteristics were concluded both verbally and graphically. A conclusion evaluates short-term and long-term impacts of ambient temperature on rate capability, ageing, capacity fade and longevity.
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The studying of some markers of transforming growth factor pathway in mouse model of atherosclerosis.
Pagurko, Lukáš ; Nachtigal, Petr (advisor) ; Doleželová, Eva (referee)
Abstracts Lukáš Pagurko The studying of some markers of transforming growth factor pathway in mouse model of atherosclerosis. Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové Pharmacy Background: We observed the expression of endothelial nitric oxide synthase (eNOS) in mice atherosclerotic plaque by using imunohistochemical methods. The aim was to prove nonlipid-lowering effects of atorvastatin to affect the expression of eNOS. Methods: Female apoE and LDLr deficient mice, aged 16 weeks were used in the study. Biochemical analysis of blood samples and imunohistochemical analysis of the tissue segments were performed. For identification of eNOS expression was used EnVision method with DAB visualization. Results: We found out in biochemical analysis that 8-weeks doses of atorvastatin significantly increases levels of overall cholesterol. Presence of atherosclerotic lesions was observed at all incisions in control group even in atorvastatin group, whereas aterom necrotic fibres was founded at a number of them. The administration of atorvastatin were lead to significant decrease of atherosclerotic lesions compared to untreated group. There were also rapid increase of eNOS expression especially on the surface of atherosclerotic lesions. Conclusion: The positive influence of...
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The study of VCAM-1 expression in experimental atherogenesis
Mertlíková, Veronika ; Nachtigal, Petr (advisor) ; Doleželová, Eva (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Veronika Mertlíková Supervisor: Doc. PharmDr. Petr Nachtigal Ph.D. Title of diploma thesis: The study of VCAM-1 expression in experimental atherogenesis. The aim of the thesis is to describe the expression of VCAM-1 in the vessel wall of normocholesterolemic C57BL/6J mice, which were fed standard laboratory diet, and hypercholesterolemic apoE-deficient mice. As an experimental model normocholesterolemic C57BL/6J male mice and apoE-deficient mice at the age of 6 weeks were used. The C57BL/6J male mice were fed standard laboratory diet and apoE-deficient mice were fed cholesterol diet for 8 weeks. After this procedure a biochemical analysis of blood and immunohistochemical analysis of segments taken from aortic sinus and aortal arch were made. In comparison with the control C57BL/6J mice a large level of cholesterol was found in the blood of the apoE-deficient mice. Atherosclerotic lesions are thus generated only by the hypercholesterolemic mice. We were monitoring the expression of VCAM-1 in aortas of the normocholesterolemic C57BL/6J mice without atherosclerotic lesions by immunohistochemical methods, and the same methods were used for monitoring of the areas with and without...
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Alteration of transport proteins expression during intrahepatic cholestasis in rats
Kolouch, Jan ; Doleželová, Eva (advisor) ; Cermanová, Jolana (referee)
Jan Kolouch Alteration of transport proteins expression during intrahepatic cholestasis in rats Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové Pharmacy Background: The aim of the diploma thesis was the verification of cholestatic liver injury by biochemical analysis of plasma and analysis of the main efflux and uptake hepatic transporters (Ntcp, Oatp1a4, Bsep, Mrp2, Mrp3, Mrp4) at the mRNA level. Methods: Wistar rats (n = 6, in each group; 280 - 320 g) were divided into two groups: Control group (LPS-K) and LPS group (lipopolysaccharide was administred at once i.p., 4mg/kg). Blood and liver samples were collected 12 hours after LPS administration. Biochemical analysis of plasma was performed by Cobas Integra ® 800 and GC/MS. Changes of mRNA expression of the transporters were evaluated by qRT-PCR. Results: In comparison to control group, LPS group showed significantly elevated plasmatic levels of the bile acids and also elevated activity of ALP and GMT. Plasmatic levels of bile acids were elevated to 818%, activity of ALP was elevated to 311% and activity of GMT to 2167%. Intrahepatic cholestasis led to the significant decrease of mRNA levels - Ntcp to 4.6%, Oatp1a4 to 2.2%, Mrp2 to 1.7% and Bsep to 25%. Conclusion: According to the results of this study, it is...
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The study of transforming growth factor receptor during atherogenesis in mouse model of atherosclerosis.
Vybulková, Lucie ; Nachtigal, Petr (advisor) ; Doleželová, Eva (referee)
Lucie Vybulková The study of transforming growth factor receptor during atherogenesis in mouse model of atherosclerosis Diploma thesis Charles University in Prague, Fakulty of Pharmacy in Hradec Králové Pharmacy Background: The aim of this diploma thesis was the establishment of methodology for detection of TGF-βRI, subtype ALK-5, and studying its expression in the aortic root in apoE/LDLr- deficient mice. Methods: Using female mice C57BL/6J strain with a double deficit of apolipoprotein E and LDL-receptor was performed biochemical analysis of blood specimens, histologic staining with oil red for detection of lipids in tissues and immunohistochemical analysis of segments of tissue from the aorta and the top half of the heart. To detect expression of ALK-5 was used EnVision method with DAB visualization. Results: Using biochemical analysis, we confirmed increased levels of cholesterol in mice fed cholesterol diet as compared with mice on standard diet. At histologic staining with oil red we detected increased formation of atherosclerotic lesions in mice with cholesterol diet. Immunohistochemical analysis of expression of ALK-5 we demonstrated high expression of ALK-5 in the tunica media and in atherosclerotic plaques with no significant difference in the two groups of mice. Conclusion: The results...
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Immunohistochemical Analysis of Expression of Phosphorylated form Smad2 after Administration of Atorvastatin in Experimental Atherogenesis
Vybulková, Lucie ; Nachtigal, Petr (advisor) ; Doleželová, Eva (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate Mgr.Lucie Vybulková Consultant Doc.PharmDr.Petr Nachtigal, PhD Title of Thesis Immunohistochemical analysis of expression of phosphorylated form Smad2 after administration of atorvastatin in experimental atherogenesis Background: The aim of this thesis was to describe the effects of atorvastatin treatment on the expression of phosphorylated form of Smad2 in atherosclerotic plaques in ApoE/LDLr-deficient mice by immunohistochemical methods. Furthermore, the influence of atorvastatin on lipid spectrum and size of atherosclerotic plaques was observed. Methods: In our experiment there were used C57BL/6J female mice with double deficit of apolipoprotein E and LDL receptor. There was performed the biochemical analysis of blood samples, histological staining with oil red for detection of tissue lipids, quantitative analysis of size of lesions and immunohistochemical analysis of samples containing semilunar valves and aorta for the detection of expression of Smad2. It was done using the method Avidin-Biotin and detection with DAB. Results: Using biochemical analysis we confirmed increased levels of total cholesterol and VLDL after the administration of atorvastatin. Smaller size of...
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