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Colorectal cancer - from patogenesis to screening. Colorectal carcinogenesis in ulcerative colitis with primary sclerosing cholangitis and the issue of the screening of the colorectal cancer.
Wohl, Pavel ; Špičák, Julius (advisor) ; Škarda, Jozef (referee) ; Gregor, Martin (referee)
Colorectal carcinoma (CRC) ranks high in mortality and morbidity in most developed countries. Following theses focus on specific aspects of colorectal carcinoma pathogenesis including the issue of screening. The goal of the first study was assessment of expression of epithelial markers of colorectal carcinogenesis p53, COX-2, bcl-2. The study included patients with active ulcerative colitis (UCA), ulcerative colitis in remission (UCR), primary sclerosing cholangitis with ulcerative colitis (PSC-UC) (PSC), patients after liver transplantation for PSC (OLT) and a control group (N). We found significantly increased expression of tumour suppressor gene p53 in non-dysplastic mucosae in PSC-UC compared with UCA, UCR, OLT, and N, which may indicate higher neoplastic potential of PSC. Statistically significant correlation was found between PSC incidence and p53 expression. Surprisingly, OLT showed no p53 expression in non-dysplastic mucosa compared with PSC-UC. This indicates that PSC may contribute to increased expression of p53 and p53-induced colorectal carcinogenesis. Furthermore, a correlation between expression of p53 and COX-2 together with the increased expression of bcl-2 in UCA compared to N can support the role of inflammation in colorectal carcinogenesis. The goal of the second study was...
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The cae about patient with liver transplant
Juzová, Lucie ; Bartůněk, Petr (advisor) ; Wohl, Pavel (referee)
I wrote my thesis about The care of patient with transplant liver. The work is divided into theoretical and practical part. I directed the theoretical part to anatomy and function of liver and gall-bladder ways, liver's diseases, which conducted to transplant of liver patiens, whose case reports I will work in the practical part. I present etiology, clinical symptoms, diagnostik, complication and treatment of diseases. I paid attention a special chapter to problematic of transplant of liver. In the practical part I work out case report sof two patiens with transplant of liver, who were hospitalized in Clinical anesteziology, resuscitation and intesive care in IKEM. In the first case report I describe course of hospitalization of patient with liver cirrhosis. In the second case report I desribe course of hospitalization of patient with acute hepatic failure on the strength of Wilson's disease. At first I work out a course of important days for treatment.I took nursing anamnesis. I set needs of patiens and then I describe nursing interventions. In summary I present nursing diagnosis.I evaluated nursing care and whole course of hospitalization. At the end I compare a course of treatment about the patiens with different diagnosis. I describe how I took steps during writting my work and I informed about my...
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