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The Steel Structure of a Factory Building
Ivánek, Robert ; Barnat, Jan (referee) ; Štrba, Michal (advisor)
Item of Master´s thesis is to design, review and compare two variants of steel structures production hall with overhead crane with load capacity 25t. One variant is frame construction and second one is construction with trusses. Layout dimensions is 45m x 60m and the height of the ridge is 10m. Stability is provided by wall and roof bracings. Building is sheathed. Structures is situated in Frýdek - Místek.
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DNA Microarrays and Bioinformatics in Biomedical Research
Ivánek, Robert ; Forejt, Jiří (advisor) ; Martásek, Pavel (referee) ; Beneš, Ivan (referee)
Abstr€gt DNA microanays ť€present a relatively novel tecbnique for qualitative and quartitative analysis of nucleic acids. In various modificďions tbis tecbniqueďows expressionmalysis' comparative genomic Mridizatiotr, micronNe profiling, analysis of geire regulation md deteďon ďpolymorpbism or mutations.In this thesisI presentan overview ďvarious types of microarays and theř applióations in biomedical reserch. I documett their usefulnessful severalprojecb aimedatidentificatioaof diseasecausinggenes(Mucopolysaoetaidosis lII€, ATP syntbasedefieielrcy),at moleculaÍchaae*erizatim ď h'man disws using cell lines (clear cell renal carcinoma,acutemyeloid leukaenia) or meute modďs (meiotic ďlonoiug of unsynapsedcbronatin). My work de'monsbtes that oompetentapplication of microarray techiqge4. bve pobqtiel to speed rrp biomedicď re"searcáod already bocane one of its frrndmental analyticalapproaches. ' t
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The Steel Structure of a Factory Building
Ivánek, Robert ; Barnat, Jan (referee) ; Štrba, Michal (advisor)
Item of Master´s thesis is to design, review and compare two variants of steel structures production hall with overhead crane with load capacity 25t. One variant is frame construction and second one is construction with trusses. Layout dimensions is 45m x 60m and the height of the ridge is 10m. Stability is provided by wall and roof bracings. Building is sheathed. Structures is situated in Frýdek - Místek.
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Analýza samčí sterility způsobené T(16,17)43H chromosomální translokací
Čapková, Jana ; Homolka, David ; Ivánek, Robert ; Jansa, Petr ; Forejt, Jiří
Heterozygosity for certain mouse and human chromosomal rearrangements is characterized by male-limited sterility. Our model of a male-sterile chromosomal rearrangement represents mouse T(16;17)43H (T43) chromosomal translocation. The effect of the T43H translocation on spermatogenesis was studied. We analyzed meiosis in B10.T43/+ heterozygous male mice and we have obtained direct evidence on the transcriptional silencing of unsynapsed autosomal chromatin of the translocation quadrivalent and the subsequent failure of the X chromosome transcriptional inactivation at the mid-late pachytene of spermatogenesis.
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