Název: Enasidenib jako inhibitor isocitrátdehydrogenasy 2 synergizuje cytotoxicitu daunorubicinu cílením na aldo-ketoreduktasu 1C3.
Překlad názvu: Isocitrate dehydrogenase 2 inhibitor enasidenib synergizes daunorubicin cytotoxicity by targeting aldo-keto reductase 1C3.
Autoři: Haddad, Andro ; Wsól, Vladimír (vedoucí práce) ; Macháček, Miloslav (oponent)
Typ dokumentu: Diplomové práce
Rok: 2023
Jazyk: eng
Abstrakt: Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Andro Haddad Supervisor: prof. Ing. Vladimír Wsól, Ph.D. Consultant: Anselm Morell García, Ph.D. Title of diploma thesis: ISOCITRATE DEHYDROGENASE 2 INHIBITOR ENASIDENIB SYNERGIZES DAUNORUBICIN CYTOTOXICITY BY TARGETING ALDO-KETO REDUCTASE 1C3 Treatment with anthracyclines is crucial in treating several oncologic disorders. However, several molecular mechanisms hinder the effectivity of anthracyclines, which is a significant obstacle in cancer therapy. Carbonyl reducing enzymes (CREs), a type of NAD(P)H-dependent oxidoreductase, contribute to anthracycline resistance by reducing these drugs to fewer active alcohols. These enzymes also play a role in the proliferation and differentiation of cancer cells, leading to increased tumour aggressiveness. Therefore, targeting these enzymes is essential for effective anticancer therapy. This study aimed to uncover the potential off-targets of the isocitrate dehydrogenase (IDH) inhibitor enasidenib (ENA) that could counteract the resistance to anthracycline, specifically in relation to the detoxification role of CREs. For this, we screened the ability of ENA to inhibit different recombinant CREs that can reduce daunorubicin (Daun) to daunorubicinol...

Instituce: Fakulty UK (VŠKP) (web)
Informace o dostupnosti dokumentu: Dostupné v digitálním repozitáři UK.
Původní záznam: http://hdl.handle.net/20.500.11956/181463

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-528011


Záznam je zařazen do těchto sbírek:
Školství > Veřejné vysoké školy > Univerzita Karlova > Fakulty UK (VŠKP)
Vysokoškolské kvalifikační práce > Diplomové práce