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Original title:
Ultrafine particles and their possible role in etiology and development of neurodegenerative diseases
Authors: Topinka, Jan ; Závodná, Táňa ; Rössnerová, Andrea ; Rössner ml., Pavel
Document type: Papers
Conference/Event: International Conference on Nanomaterials - Research and Application, NANOCON 2019 /11./, Brno (CZ), 20191016
Year: 2020
Language: eng
Abstract: Air pollutants have been shown to cause a vast amount of different adverse health effects. These effects include impairment of many respiratory (e.g. asthma, chronic obstructive pulmonary disease) and cardiovascular (ischemic heart disease, infarction, stroke) diseases. However, in recent years, the evidence showing effects beyond the lungs and circulatory system are becoming more evident. Neurological diseases, namely Alzheimer's disease (AD) has shown to be associated with living near traffic. However, reason for this has remained unresolved until today. Our new H2020 project TUBE aims on revealing the mechanisms of action of ultrafine particles involved in neurological diseases. The TUBE consortium includes experts in areas of aerosol technology, emission research, engine and fuel research, human clinical studies, epidemiology, emission inventories, inhalation toxicology, neurotoxicology and disease mechanism studies. This enables research of resolving the effects of nanoparticles from different traffic modes for both air quality and concomitant toxic effect of these air pollutants. We will investigate adverse effects of air pollutants using cell cultures, animal exposures and volunteered human exposures as well as the material from epidemiological cohort study. These are going to be compared according to inflammatory, cytotoxic and genotoxic changes and furthermore beyond the current state of the art to neurotoxic and brain health effects. With this approach, we are aiming to a comprehensive understanding of the adverse brain effects of nanoparticles from traffic.
Keywords: Alzheimer's disease; inflammation; neurodegenerative diseases; ultrafine particles
Project no.: LM2015073 (CEP), LO1508 (CEP)
Funding provider: GA MŠk, GA MŠk
Host item entry: Nanocon 2019 : Proceedings of the International Conference on Nanomaterials - Research & Application /11./, ISBN 978-80-87294-95-6
Note: Související webová stránka: https://dx.doi.org/10.37904/nanocon.2019.8558
Institution: Institute of Experimental Medicine AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: https://hdl.handle.net/11104/0341292
Permalink: http://www.nusl.cz/ntk/nusl-521718
The record appears in these collections:
Research > Institutes ASCR > Institute of Experimental Medicine
Conference materials > Papers
Authors: Topinka, Jan ; Závodná, Táňa ; Rössnerová, Andrea ; Rössner ml., Pavel
Document type: Papers
Conference/Event: International Conference on Nanomaterials - Research and Application, NANOCON 2019 /11./, Brno (CZ), 20191016
Year: 2020
Language: eng
Abstract: Air pollutants have been shown to cause a vast amount of different adverse health effects. These effects include impairment of many respiratory (e.g. asthma, chronic obstructive pulmonary disease) and cardiovascular (ischemic heart disease, infarction, stroke) diseases. However, in recent years, the evidence showing effects beyond the lungs and circulatory system are becoming more evident. Neurological diseases, namely Alzheimer's disease (AD) has shown to be associated with living near traffic. However, reason for this has remained unresolved until today. Our new H2020 project TUBE aims on revealing the mechanisms of action of ultrafine particles involved in neurological diseases. The TUBE consortium includes experts in areas of aerosol technology, emission research, engine and fuel research, human clinical studies, epidemiology, emission inventories, inhalation toxicology, neurotoxicology and disease mechanism studies. This enables research of resolving the effects of nanoparticles from different traffic modes for both air quality and concomitant toxic effect of these air pollutants. We will investigate adverse effects of air pollutants using cell cultures, animal exposures and volunteered human exposures as well as the material from epidemiological cohort study. These are going to be compared according to inflammatory, cytotoxic and genotoxic changes and furthermore beyond the current state of the art to neurotoxic and brain health effects. With this approach, we are aiming to a comprehensive understanding of the adverse brain effects of nanoparticles from traffic.
Keywords: Alzheimer's disease; inflammation; neurodegenerative diseases; ultrafine particles
Project no.: LM2015073 (CEP), LO1508 (CEP)
Funding provider: GA MŠk, GA MŠk
Host item entry: Nanocon 2019 : Proceedings of the International Conference on Nanomaterials - Research & Application /11./, ISBN 978-80-87294-95-6
Note: Související webová stránka: https://dx.doi.org/10.37904/nanocon.2019.8558
Institution: Institute of Experimental Medicine AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: https://hdl.handle.net/11104/0341292
Permalink: http://www.nusl.cz/ntk/nusl-521718
The record appears in these collections:
Research > Institutes ASCR > Institute of Experimental Medicine
Conference materials > Papers
Record created 2023-03-26, last modified 2023-03-26