Název: Reimplementation of the Connectivity Map with Accessibility Enhancements
Autoři: ARICANLI, Evren
Typ dokumentu: Bakalářské práce
Rok: 2020
Jazyk: eng
Abstrakt: The Connectivity Map (CMap) is a biomedical research tool which leverages modern biotechnology and bioinformatic methods to provide a platform for comparing the a subject gene expression profile against a library of drug-treatment gene expression profiles. This comparison allows for retrieval of drugs from the CMap's library which induce biological activity similar (or dissimilar) to a given subject expression profile -- thereby making it a tool which allows for the finding of repositionable drugs. Herein, a number of adaptations are proposed -- most focally being changes which would enhance the tool's accessibility (e.g. a simplified UI/workflow, expanded queryable gene identifiers). Using the R statistical computing environment and numerous libraries available through it, an adapted CMap tool was created from the publically-accessible CMap data, which housed the proposed adaptations. To evaluate success of the accessibility adaptations, the adapted CMap tool was focus tested on several participants -- which ultimately yielded great favor for the changes made, allowing them to be conclusively suggested for future iterations of the CMap.
Klíčová slova: Connectivity Map; Custom Microarray CDFs; DNA microarrays; Drug Repositioning; Factor Analysis for Robust Microarray Summarization; Gene Expression Analysis; User Interface Accessibilty
Citace: ARICANLI, Evren. Reimplementation of the Connectivity Map with Accessibility Enhancements. České Budějovice, 2020. bakalářská práce (Bc.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Instituce: Jihočeská univerzita v Českých Budějovicích (web)
Informace o dostupnosti dokumentu: Plný text je dostupný v digitálním repozitáři JČU.
Původní záznam: http://www.jcu.cz/vskp/63009

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-517521


Záznam je zařazen do těchto sbírek:
Školství > Veřejné vysoké školy > Jihočeská univerzita v Českých Budějovicích
Vysokoškolské kvalifikační práce > Bakalářské práce