Original title: Structural variability of cyclic cyanobacterial lipopeptides: their biosynthesis and features affecting their bioactivity
Authors: HÁJEK, Jan
Document type: Doctoral theses
Year: 2021
Language: eng
Abstract: This thesis is devoted to the diversity of cyanobacterial cyclic lipopeptides and their bioactivity. Special class of cyclic cyanobacterial lipopeptides puwainaphycins and minutissamides was studied in terms of their structural diversity, biosynthesis and structure-activity relationship. Chemical diversity of observed variants in cyanobacterial strains was correlated with the genetic background for their biosynthesis from which the probable cores of biosynthesis were inferred. Biological activity (mainly the cytotoxicity and anti-fungal activity) of major natural puwainaphycin and minutissamide variants was studied in detail. Finally, semi-synthetic puwainaphycin and minutissamide variants were prepared in order to study the relationship between distinct functional moieties and their effect on the bioactivity of the lipopeptide.
Keywords: bioactivity; cyanobacteria; cyclic lipopeptide
Citation: HÁJEK, Jan. Structural variability of cyclic cyanobacterial lipopeptides: their biosynthesis and features affecting their bioactivity. České Budějovice, 2021. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/39926

Permalink: http://www.nusl.cz/ntk/nusl-513444


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Doctoral theses