Pokroky ve výzkumu a testování anthelmintik

Nguyen, Thuy Linh

Charles University, Faculty of Pharmacy in Hradec Králové Training Workplace Department of Biochemical Sciences Doctoral Degree Program Xenobiochemistry and Pathobiochemistry Candidate Mgr. Thuy Linh Nguyen Supervisor Prof. RNDr. Lenka Skálová, Ph.D. Advisor Assoc. Prof. Ing. Petra Matoušková, Ph.D. Title of Doctoral Thesis Advances in the discovery and testing of anthelmintics The parasitic nematodes cause a considerable problem in human and animal health worldwide. The group of gastrointestinal nematodes is responsible for economic losses in livestock production. The treatment relies on the use of a limited number of anthelmintics, but their efficacy is hampered due to widespread drug resistance. Given the need for new drugs, the present thesis focuses on discovering novel compounds with potential anthelmintic effects and on the development of testing methods. Based on the literature search, we presented the possible approaches in the current development of new anthelmintics and evaluated their advantages and disadvantages in a review article. For the experiments, we used a model organism Haemonchus contortus, which is one of the most important gastrointestinal pathogens of small ruminants. The primary phenotypic screening of a small compound library against larvae identified two 'hit' compounds...

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