Název: Imunitní reaktivita T lymfocytů jaterní tkáně a jejich podíl v patogenezi jaterních onemocnění
Překlad názvu: Immune Reactivity of Hepatic T Lymphocytes and Their Role in Pathogenesis of Liver Diseases
Autoři: Carey, Ivana ; Vítek, Libor (vedoucí práce) ; Urbánek, Petr (oponent) ; Červinková, Zuzana (oponent)
Typ dokumentu: Disertační práce
Rok: 2006
Jazyk: eng
Abstrakt: The interaction of different pathogens with systemic and liver immune system is suggested an important factor in pathogenesis of various liver diseases. The variable aspects of this interaction and different immune system patways were subject of the present thesis. The ultimate goal of the present thesis was to investigate the reactivity of the local and systemic immune system against different disease related antigens and to demonstrate their participation in liver diseases and liver damage pathogenesis. Chronic hepatitis B infection, chronic hepatitis C infection and drug-induced liver damage were investigeted by 7 different studies using ex-vivo and in-vitro methods. In general, chronic liver diseases are associated with increased oxidative stress. Due to this fact, the role bilirubin, a potent endogenous antioxidant, was also analysed. The results of presented studies demonstrate clearly active participation of immune system to the pathogenesis of liver diseases, its direct involvement in liver damage and its effect on outcome of disease. The protective role of bilirubin in oxidative stress was confirmed. In conclusion, the results of all presented studies in this thesis illustrate the role of systemic as well as liver based immune system as a crucial player in the pathogenesis of liver...

Instituce: Fakulty UK (VŠKP) (web)
Informace o dostupnosti dokumentu: Dostupné v digitálním repozitáři UK.
Původní záznam: http://hdl.handle.net/20.500.11956/6443

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-488108


Záznam je zařazen do těchto sbírek:
Školství > Veřejné vysoké školy > Univerzita Karlova > Fakulty UK (VŠKP)
Vysokoškolské kvalifikační práce > Disertační práce