Original title: Mathematics and Optimal control theory meet Pharmacy: Towards application of special techniques in modeling, control and optimization of biochemical networks
Authors: Papáček, Štěpán ; Matonoha, Ctirad ; Duintjer Tebbens, Jurjen
Document type: Papers
Conference/Event: SNA'21 Seminar on Numerical Analysis Modelling and Simulation of Challenging Engineering Problems (SNA'21 2021), Ostrava (CZ), 20210125
Year: 2021
Language: eng
Abstract: Similarly to other scienti c domains, the expenses related to in silico modeling in pharmacology need not be extensively apologized. Vis a vis both in vitro and in vivo experiments, physiologically-based pharmacokinetic (PBPK) and pharmacodynamic models represent an important tool for the assessment of drug safety before its approval, as well as a viable option in designing dosing regimens. In this contribution, some special techniques related to the mathematical modeling, control and optimization of biochemical networks are presented on a paradigmatic example of enzyme kinetics.
Keywords: Biochemical network; Dynamical system; Input-output regulation; Optimization; Systems pharmacology
Project no.: GA19-05872S (CEP)
Funding provider: GA ČR
Host item entry: Proceedings of the SNA'21 Seminar on Numerical Analysis Modelling and Simulation of Challenging Engineering Problems, ISBN 978-80-86407-82-1

Institution: Institute of Information Theory and Automation AS ČR (web)
Document availability information: Fulltext is available at external website.
External URL: http://www.ugn.cas.cz/event/2021/sna/files/sna21-sbornik.pdf
Original record: http://hdl.handle.net/11104/0316506

Permalink: http://www.nusl.cz/ntk/nusl-433007


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Conference materials > Papers