Original title: Modeling of nucleolar self-assembly
Authors: Blažíková, Michaela ; Heřman, P. ; Malínský, Jan
Document type: Papers
Conference/Event: Proceedings of the International Conference on Modelling and Simulation 2010, Praha (CZ), 2010-06-22 / 2010-06-25
Year: 2010
Language: eng
Abstract: Mammalian cell nucleoli disassemble at the beginning of mitosis and reassemble again during telophase and the early G1. Dynamics of this process was studied using a model based on entropy driven self-assembly of pre-ribosomal particles generated in a single biosynthetic source. Monte Carlo simulations revealed that such model can explain formation of a large aggregate, a nucleolus, in the vicinity of the source. We examined influence of nucleoplasm properties on dynamics of the aggregate formation.
Keywords: Monte Carlo simulations
Project no.: CEZ:AV0Z50390512 (CEP), GA204/07/0133 (CEP), KAN200520801 (CEP), 0021620835
Funding provider: GA ČR, GA AV ČR, GA MŠk
Host item entry: MS'10 Prague, ISBN 978-80-01-04574-9

Institution: Institute of Experimental Medicine AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0191512

Permalink: http://www.nusl.cz/ntk/nusl-42162


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Research > Institutes ASCR > Institute of Experimental Medicine
Conference materials > Papers