Original title: Electrochemistry of selected radiosenzitizer-etanidazole
Authors: Gál, Miroslav ; Híveš, J. ; Sokolová, Romana ; Hromadová, Magdaléna ; Kocábová, Jana ; Kolivoška, Viliam ; Pospíšil, Lubomír
Document type: Papers
Conference/Event: Modern Electroanalytical Methods /30./, Jetřichovice (CZ), 2010-05-24 / 2010-05-28
Year: 2010
Language: eng
Abstract: The first electron transfer to radiosensitizer etanidazole (ETN) and ETN radical anion formation in buffered aqueous media was studied by means of voltammetric techniques and Electrochemical Impendance Spectroscopy (EIS). The heterogeneous electron transfer rate constant for the first reduction of ETN (radical anion production) k0 for the redox couple and so called E1,7 potential were calculated. The obtained values of k0 and E1,7 potential indicate that ETN compared to some other possible chemical radiosensitizers requires lower energy to accept the first electron during metabolic pathway.
Keywords: cyclic voltammetry; electrochemical impendance spectroscopy; etanidazole; radiosensitizers
Project no.: CEZ:AV0Z40400503 (CEP), GP203/09/P502 (CEP), LC510 (CEP), OC 140
Funding provider: GA ČR, GA MŠk, GA MŠk
Host item entry: Sborník přednášek. XXX. Moderní elektroanalytické metody, ISBN 978-80-254-6710-7

Institution: J. Heyrovsky Institute of Physical Chemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0185965

Permalink: http://www.nusl.cz/ntk/nusl-41485


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Research > Institutes ASCR > J. Heyrovsky Institute of Physical Chemistry
Conference materials > Papers