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Original title:
Microscopic study of multifunctional drug molecule adhesion to electronic biosensors coated with diamond and gold nanoparticles
Authors: Finsterle, T. ; Pilarčíková, I. ; Bláhová, I.A. ; Potocký, Štěpán ; Kromka, Alexander ; Ukraintsev, Egor ; Nepovimová, E. ; Musílek, K. ; Kuča, K. ; Rezek, B.
Document type: Papers
Conference/Event: NANOCON 2018 -International Conference on Nanomaterials - Research and Application /10./, Brno (CZ), 20181017
Year: 2019
Language: eng
Abstract: The easy and fast detection of drug content and concentration levels is demanded in biological research as well as in clinical practice. Here we study on microscopic level how nanodiamonds and gold nanoparticles interact with a multifunctional drug molecule directly on a biosensor surface. The sensors are made of interdigitated Au electrodes coated by 5 nm hydrogenated or oxidized nanodiamonds and further combined with Au colloidal nanoparticles (size 20 nm) providing nanoscale composite (spacing 100 nm). Atomic force microscopy is employed to measure local tip-surface adhesion forces and surface topography. AFM adhesion maps show that the drug binds to all types of nanoparticles and the adhesion is also significantly influenced by the substrates on which the nanoparticles are deposited. Role of local AFM tip interaction with nanostructured surface is also discussed.\n
Keywords: alzheimer drugs; biosensors; nanodiamonds; nanoparticles
Project no.: LM2015087 (CEP)
Funding provider: GA MŠk
Host item entry: NANOCON 2018 : Conference Proceedings of the International Conference on Nanomaterials - Research & Application /10./, ISBN 978-80-87294-89-5
Institution: Institute of Physics AS ČR (web)
Document availability information: Fulltext is available at external website.
External URL: https://www.nanocon.eu/files/uploads/01/NANOCON2018%20-%20Conference%20Proceedings_content.pdf
Original record: http://hdl.handle.net/11104/0306586
Permalink: http://www.nusl.cz/ntk/nusl-409695
The record appears in these collections:
Research > Institutes ASCR > Institute of Physics
Conference materials > Papers
Authors: Finsterle, T. ; Pilarčíková, I. ; Bláhová, I.A. ; Potocký, Štěpán ; Kromka, Alexander ; Ukraintsev, Egor ; Nepovimová, E. ; Musílek, K. ; Kuča, K. ; Rezek, B.
Document type: Papers
Conference/Event: NANOCON 2018 -International Conference on Nanomaterials - Research and Application /10./, Brno (CZ), 20181017
Year: 2019
Language: eng
Abstract: The easy and fast detection of drug content and concentration levels is demanded in biological research as well as in clinical practice. Here we study on microscopic level how nanodiamonds and gold nanoparticles interact with a multifunctional drug molecule directly on a biosensor surface. The sensors are made of interdigitated Au electrodes coated by 5 nm hydrogenated or oxidized nanodiamonds and further combined with Au colloidal nanoparticles (size 20 nm) providing nanoscale composite (spacing 100 nm). Atomic force microscopy is employed to measure local tip-surface adhesion forces and surface topography. AFM adhesion maps show that the drug binds to all types of nanoparticles and the adhesion is also significantly influenced by the substrates on which the nanoparticles are deposited. Role of local AFM tip interaction with nanostructured surface is also discussed.\n
Keywords: alzheimer drugs; biosensors; nanodiamonds; nanoparticles
Project no.: LM2015087 (CEP)
Funding provider: GA MŠk
Host item entry: NANOCON 2018 : Conference Proceedings of the International Conference on Nanomaterials - Research & Application /10./, ISBN 978-80-87294-89-5
Institution: Institute of Physics AS ČR (web)
Document availability information: Fulltext is available at external website.
External URL: https://www.nanocon.eu/files/uploads/01/NANOCON2018%20-%20Conference%20Proceedings_content.pdf
Original record: http://hdl.handle.net/11104/0306586
Permalink: http://www.nusl.cz/ntk/nusl-409695
The record appears in these collections:
Research > Institutes ASCR > Institute of Physics
Conference materials > Papers
Record created 2020-02-12, last modified 2021-11-24