Original title: Novel Reactive Groups for Modification DNA by Oxoosmium Complexes
Authors: Havran, Luděk ; Vidláková, Pavlína ; Špaček, Jan ; Hermanová, Monika ; Fojta, Miroslav
Document type: Papers
Conference/Event: Moderní elektrochemické metody /37./, Jetřichovice (CZ), 20170515
Year: 2017
Language: eng
Abstract: DNA is naturally electroactive moleclue producing several intrinsie voltammetric signals. Some of them found appliction in electrochemical analysis of DNA interactions and damage. In particular types of applictaions is a suitable use DNA labelling by redox active tags to increase selectivity and sensitivity of analysis.One type of long-term used tags are complexes of osmium tetroxide with nittrogen ligunds (Os,L). These complexes preferentially react with pyrimidines in single stand DNA producing electractive adducts. primary reaction site for Os,L is C-C double bond in pyrimidine nucleobases. In this contribution will be presented results acquired with DNA containing chemically modified nuclebase.
Keywords: Chemically modified DNA; nucleic-acids; osmium; Oxoosmium complexes
Project no.: GA15-08434S (CEP)
Funding provider: GA ČR
Host item entry: XXXVII. Moderní elektrochemické metody. Sborník přednášek mezinárodní odborné konference, ISBN 978-80-905221-5-2

Institution: Institute of Biophysics AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0297860

Permalink: http://www.nusl.cz/ntk/nusl-396396


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Research > Institutes ASCR > Institute of Biophysics
Conference materials > Papers
 Record created 2019-07-25, last modified 2022-09-29


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