Original title: A role of Sirt1 in the Notch signalling pathway.
Authors: HORVÁTH, Matej
Document type: Doctoral theses
Year: 2017
Language: eng
Abstract: The aim of this thesis was to examine role of Sirt1 in the Notch signalling pathway, using Drosophila as a model organism. Based on in vivo and in vitro studies, we conclude that Sirt1 plays a positive role in Notch signalling. In embryonic S2N cells, Sirt1 is responsible for the protection from metabolic stress-induced down-regulation of subset of E(Spl) genes. During development, Sirt1 is responsible for proper Notch-dependent specification of SOPs and wing development. Sirt1 can regulate the Notch signalling on multiple levels via deacetylation of various substrates involved in the Notch signalling revealed by our proteomic survey.
Keywords: Drosophila development; metabolic sensor; metabolic stress; Notch signalling; S2N cells; Sirt1
Citation: HORVÁTH, Matej. A role of Sirt1 in the Notch signalling pathway.. České Budějovice, 2017. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/21902

Permalink: http://www.nusl.cz/ntk/nusl-363584


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Doctoral theses