Original title: Prognostické a prediktivní faktory karcinomu prsu
Translated title: Prognostic and Predictive Factors in Breast Cancer
Authors: Šefrhansová, Lucie ; Fínek, Jindřich (advisor) ; Pešek, Miloš (referee) ; Tesařová, Petra (referee) ; Nekulová, Miroslava (referee)
Document type: Doctoral theses
Year: 2012
Language: cze
Abstract: of dissertation thesis Prognostic and Predictive Factors in Breast Cancer The mRNA Expression of Selected Genes in Normal and Tumor Breast Tissue Samples and Theirs Clinical Value in Breast Cancer L.Šefrhansová Background: The aim of this work was to describe and to evaluate possibilities of prognosis and prediction in breast cancer. Within the framework of this study-work we carry out a prospective clinical study. The aim of this prospective study was to detect mRNA MMP-7, p53 and TIMP-1 expression in normal and tumor breast tissue samples and to determine the clinical and prognostic significance of our results. Prognosis and prediction: The tumor size, lymph node status, presence of distant metastasis, differentiation of the tumor, perivascular invasion, mitotic activity, expression of ER, PR and HER2 receptors are the basic prognostic factors in breast cancer. Age under/above 35 years was included among independent prognostic breast cancer factors in 2005. It is approved to use uPA/PAI to assess prognosis in node negative breast cancer patients. The hormone receptor status and HER-2 receptor status are the only two predictive markers associated with the target therapy. OncotypeDX analysis could be use to predict the disease recurrence interval of patients with estrogen positive and node negative...
Keywords: breast cancer; prediction; prognosis; karcinom prsu; predikce; prognóza

Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/44164

Permalink: http://www.nusl.cz/ntk/nusl-308458

The record appears in these collections:
Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Doctoral theses
 Record created 2017-05-09, last modified 2018-12-08

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