Original title: Cytotoxicity screen of the acyclic nucleoside phosphonates against bloodstream stage of \kur{Trypanosoma brucei} and validation of their putative target hypoxanthine/xanthine/guanine phosphoribosyltransferase
Authors: MITTERMAYR, Martina
Document type: Bachelor's theses
Year: 2012
Language: eng
Abstract: The aim of this study was to test several compounds of acyclic nucleoside phosphonates (ANPs), which are thought to inhibit the purine salvage pathway enzyme hypoxanthine/xanthine/guanine phosphoribosyltransferase (HGXPRT) of the bloodstream stage of Trypanosoma brucei. Further we intended to elucidate if HGXPRT enzymes are essential for the survival of the bloodstream T.brucei.
Keywords: acyclic nucleoside phosphonates; AlamarBlue; ANP; bloodstream T.brucei; HAT; HGXPRT; Human African Trypanosomiasis; purine salvage pathway; RNAi; Trypanosoma brucei
Citation: MITTERMAYR, Martina. Cytotoxicity screen of the acyclic nucleoside phosphonates against bloodstream stage of \kur{Trypanosoma brucei} and validation of their putative target hypoxanthine/xanthine/guanine phosphoribosyltransferase. České Budějovice, 2012. bakalářská práce (Bc.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/25209

Permalink: http://www.nusl.cz/ntk/nusl-135758


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Bachelor's theses