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Human ecosystem
Lapšanská, Gabriela ; Vitková, Lubica (referee) ; Mléčka, Jan (advisor)
The diploma thesis focuses on the conversion of a railway brownfield. Abandoned and contaminated areas are currently becoming valuable resources for ecological sustainability and contribute to improving the quality of life in the city. The aim of the work is to find alternatives while respecting the existing construction with minor architectural interventions. Connecting the area with the urban structure, meaningful functional fulfillment, and year-round programming ensure the pulsation of a ‚living center‘ in the emerging landscape forest park.
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Polná ideal, the castle and under the castle
Kapraľová, Kristína ; Sedlák, Jan (referee) ; Kiszka, Josef (advisor)
The aim of the work is regeneration and reclamation of the main formal places and points in the Polna town, on the level of the town (part of the town), the castle complex and the main court. Using the town acupuncture method and focusing on the main and the most important parts, I created the system of segments (plateaus), which like the separate elements create the appearance of the town as a whole. In my diploma thesis I focused on segment of castle complex. Using the gradual regeneration of the main formally important places and points, I created its overall “ideal” condition. The result of my work is the design of alternative use of castle complex and castle court elements.
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Anti-tumor activity of mesenchymal stem cells
Džuganová, Barbora ; Krulová, Magdaléna (advisor) ; Indrová, Marie (referee)
Mesenchymal stem cells (MSCs) are multipotent cells with the ability to migrate to inflammation sites and to tumor sites. They are able to regenerate the damaged tissues and also easy to isolate and cultivate. Furthermore, they can inhibit tumor cells and modulate the immune response. They are non-toxic in the organism and genetic modification of them can enhance their antitumor effect. MSCs can also serve as a vehicle for delivery of the therapeutic agent to the tumor. These properties make them special for anti-tumor therapy. Under some conditions, MSCs can also stimulate the tumor growth. This work discusses conditions in which MSCs inhibit the growth of cancer cells, as it is not yet clear on which precise mechanisms this inhibition is based.
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Molecular mechanisms of vertebrate limb regeneration
Onhajzer, Jakub ; Krylov, Vladimír (advisor) ; Soukup, Vladimír (referee)
Limb regeneration fascinates innumerable scientists for decades. Urodele amphibians can regenerate their limbs perfectly. This ability is preserved for a whole lifetime. However, they are not the only ones who regenerate their limbs. Second species are anuran amphibians, but their ability to promote limb regeneration take place only throughout a larval stage. Both groups belong to amphibians. Limbs are regeneated by the process called epimorphosis. The primary process is formation of blastema, mass of heterogeneous dedifferetiated cells, which are unipotent with the capacity to redifferentiate into only one cell type. Essential factor is the regulation of limb regeneration by numerous molecular mechanisms in order to achieve the perfect limb shape, without unwanted tumors. Mechanisms allowing limb regeneration in lower vertebrates would be applied via regenerative medicine in higher vertebrates in the future. Keywords: regeneration, limb, epimorphosis, dedifferentiation, vertebrates
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Polná ideal, the castle and under the castle
Kapraľová, Kristína ; Sedlák, Jan (referee) ; Kiszka, Josef (advisor)
The aim of the work is regeneration and reclamation of the main formal places and points in the Polna town, on the level of the town (part of the town), the castle complex and the main court. Using the town acupuncture method and focusing on the main and the most important parts, I created the system of segments (plateaus), which like the separate elements create the appearance of the town as a whole. In my diploma thesis I focused on segment of castle complex. Using the gradual regeneration of the main formally important places and points, I created its overall “ideal” condition. The result of my work is the design of alternative use of castle complex and castle court elements.
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Molecular mechanisms of vertebrate limb regeneration
Onhajzer, Jakub ; Krylov, Vladimír (advisor) ; Soukup, Vladimír (referee)
Limb regeneration fascinates innumerable scientists for decades. Urodele amphibians can regenerate their limbs perfectly. This ability is preserved for a whole lifetime. However, they are not the only ones who regenerate their limbs. Second species are anuran amphibians, but their ability to promote limb regeneration take place only throughout a larval stage. Both groups belong to amphibians. Limbs are regeneated by the process called epimorphosis. The primary process is formation of blastema, mass of heterogeneous dedifferetiated cells, which are unipotent with the capacity to redifferentiate into only one cell type. Essential factor is the regulation of limb regeneration by numerous molecular mechanisms in order to achieve the perfect limb shape, without unwanted tumors. Mechanisms allowing limb regeneration in lower vertebrates would be applied via regenerative medicine in higher vertebrates in the future. Keywords: regeneration, limb, epimorphosis, dedifferentiation, vertebrates
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Anti-tumor activity of mesenchymal stem cells
Džuganová, Barbora ; Krulová, Magdaléna (advisor) ; Indrová, Marie (referee)
Mesenchymal stem cells (MSCs) are multipotent cells with the ability to migrate to inflammation sites and to tumor sites. They are able to regenerate the damaged tissues and also easy to isolate and cultivate. Furthermore, they can inhibit tumor cells and modulate the immune response. They are non-toxic in the organism and genetic modification of them can enhance their antitumor effect. MSCs can also serve as a vehicle for delivery of the therapeutic agent to the tumor. These properties make them special for anti-tumor therapy. Under some conditions, MSCs can also stimulate the tumor growth. This work discusses conditions in which MSCs inhibit the growth of cancer cells, as it is not yet clear on which precise mechanisms this inhibition is based.
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Zakladanie a regenerácia športových trávnikov
Petríček, Jozef
This Bachelor thesis is focused on formation and regeneration of sport field lawns. The first part of this thesis deals with the historic lawn grasses, importance of lawn grasses and brief description of basic information on lawns and grasses. Furthermore, it describes the composition of field turfs (golf course, football turfs, and tennis turfs), preparation areas and substrates for establishments of lawns, sowing dates, sowing depth and self-seeding. The second part describes the handling areas after sowing and caring of the established lawns. This part also describes regeneration of sport field lawns and specific football turfs. The conclusion focuses on transplanting turf rolls, its types, and peeling technologies and comparing the benefits of turf rolls to the disadvantages of sown lawns.
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