National Repository of Grey Literature 39 records found  1 - 10nextend  jump to record: Search took 0.01 seconds. 
Digital Biomarkers for Assessing Respiratory Disorders in Parkinson’s Disease
Kováč, Daniel ; Cvetler, Dominik
Respiratory disorders are a significant part of hypokineticdysarthria (HD) that affects patients with Parkinson’sdisease (PD). Still, their potential role in the objective assessmentof HD has not yet been fully explored, which is the primary goalof this study. Several respiratory features were designed andextracted from acoustic signals recorded during text reading.Based on these features, the XGBoost model was able to predictclinical test scores of phonorespiration with an estimated errorrate of 12.54%. Statistical analysis revealed that measuring respirationrate and quantifying signal fluctuations during inspirationhave great potential in the objective assessment of respiratorydisorders in patients with PD.
Remote and passive speech monitoring application
Klimeš, Jiří ; Mikulec, Marek (referee) ; Kováč, Daniel (advisor)
Motor speech disorders in patients with Parkinson’s disease collectively referred to as hypokinetic dysarthria, occur in the early phase of the disease. Language plays an essential role in classifying speakers into healthy and those with dysarthria. Author explains which aspects of speech are most often affected. Then explains how mobile applications work on the Android operating system, and if it is possible to use them in passive and distant speech monitoring. Then the topic of voice call recording is described and how is it possible to implement this solution. Such application is then designed and partially developed.
Virtual reality as a tool for therapy in medicine
Pecháček, Vilém ; Mekyska, Jiří (referee) ; Mucha, Ján (advisor)
Virtual reality is increasingly the subject of scientific studies dealing with the therapy of neurodegenerative diseases, and its use in combination with conventional therapy appears to be beneficial. The aim of the work is a research of the available literature on this topic and an analysis of commercially available headsets and their technologies. Another of the objectives of the work is the design and implementation of an application for the therapy of motor symptoms of Parkinson's disease with an emphasis on data collection. The application will be developed in the Unreal Engine 5 environment for the Meta Quest 2 headset.
Analysis of speech disorders in patients with a high risk of developing Lewy body diseases
Novotný, Kryštof ; Kováč, Daniel (referee) ; Mekyska, Jiří (advisor)
Lewy bodies diseases (one of the most common neurodegenerative disorders) have the same pathological basis, but the individual representatives differ in their clinical manifestations. Different diseases affect the mental or physical side of the patient to a greater or lesser extent. This work assumes that thanks to the acoustic analysis of speech, it is possible to distinguish individual diseases from one another, because the disorders of the cognitive and motor aspects of a patient reflect in speech in specific ways. The thesis aims to describe the clinical features of the main representatives of the Lewy bodies diseases, to investigate their impact on speech, to propose characterizing acoustic parameters and then to compare their discriminative power. Speech recordings from the CoBeN and preLBD databases are used as input data for the proposed algorithm. Descriptive statistics, Mann-Whitney U test, FDR correction and XGBoost machine learning model using stratified cross-validation and balanced accuracy are used for subsequent evaluation. The result are scripts for the automated calculation of speech parameters from the database and their evaluation. The results of the analysis prove that the selected diseases can really be distinguished from each other and from a healthy control based on the manifestations in speech, already in the prodromal stages.
Virtual reality as a tool for diagnosis and therapy in medicine
Kadlec, Jiří ; Mekyska, Jiří (referee) ; Mucha, Ján (advisor)
The use of virtual reality (VR) in the diagnosis and treatment of severe neurodegenerative or neurodevelopmental diseases is a potential alternative to standard methods and is now the subject of many studies and research. One of the objectives of the thesis is a detailed research and analysis of this usage. Another objective is to research and analyze the options of developing VR applications. The main objective of the thesis is the design and implementation of VR application for therapy and diagnosis of patients with Parkinson's disease. The application contain an adaptive environment and three designed exercises based on existing methods for diagnosis and therapy of patients with PD. Among other things, the application also allow you to store exercise data (such as position and rotation data of controls etc.). The implementation was done in the Unity engine with C# as a programming language, with an emphasis on patient adaptation and minimizing the development of VR disease.
Web application for speech and voice acquisition
Levák, Adam ; Galáž, Zoltán (referee) ; Mekyska, Jiří (advisor)
This bachelor’s thesis deals with designing and building a web application for speech and voice recording. The main goal of the thesis was to write a theoretical background, create a prototype and build the final web application. The theoretical background involves comparing mobile applications, a comparison of already available solutions for voice and speech recording and an introduction to database systems. The web application prototype was created in an online vector graphics editor Figma. The implementation of the actual web application, which is able to record speech exercises and voice exercises, was written in the JavaScript programming language. The application consists of a set of exercises, specifically picture description, elongated phonation, a diadochokinetic exercise, sentence repetition and text reading. Each exercise will have a text and a voice instruction assisting the user in performing the exercise correctly. Exercise recordings will be safely transferred to an online storage Google Drive. Moreover, a reward system was designed and implemented. It intends to motivate the users to do the exercises regularly, leading to more data collection as these exercises will be done repeatedly. The system is working and tested and is implemented as a progressive web application.
Functional connectivity and brain structure assessment in patients at risk of synucleinopathies
Klobušiaková, Patrícia ; Gajdoš, Martin (referee) ; Mekyska, Jiří (advisor)
Synucleinopathy is a neurodegenerative disorder characterized by the presence of pathological protein -synuclein in neurons. So far, treatment that could heal or permanently stop this disease is not known. The aim of this work is to identify prodromal stages of synucleinopathies using functional connectivity processed applying graph metrics and assessing cortical thickness and subcortical structures volumes from magnetic resonance imaging data, and to verify specificity and sensitivity of combinations of parameters that sufficiently differentiate patients in risk of synucleinopathies. To accomplish this goal, we collected data from patients in the risk of synucleinopathy (preDLB, n = 27) and healthy controls (HC, n = 28). We found reduced volume of right pallidum and increased hippocampal volume to cortical volume ratio, increased normalised clustering coefficient and higher modularity in the preDLB group in comparison to HC. These four parameters were modeled using machine learning. The resulting model differentiated preDLB and HC with balanced accuracy of 88 %, specificity of 89 % and sensitivity of 86 %. The findings of this thesis can serve as the basis for further studies searching for specific MRI markers of prodromal stage of synucleinopathy that could be targeted with therapy in the future.
Multilingual Analysis Of Hypokinetic Dysarthria In Patients With Parkinson’s Disease
Kováč, Daniel
This article deals with the multilingual analysis of hypokinetic dysarthria (HD) in patientswith Parkinson’s disease (PD). The goal is to identify acoustic features that have high discriminationpower and that are independent of the language of a speaker. The speech corpus contains 59 PD patientsand 44 healthy controls (HC) speaking in Czech (cs) and American English (en-US). Based onnon-parametric statistical tests and logistic regression, we observed the best discrimination power hasthe speech index of rhythmicity (extracted from a reading text) and harmonic-to-noise ratio (extractedfrom a sustained vowel). We were able to identify PD with 67% sensitivity and 79% specificity inthe Czech corpus and with 78% sensitivity and 67% specificity in the English one. The performanceof the model was significantly lower when combining both datasets, thus suggesting language playsa significant role during the automatic assessment of HD.
Assessing movement of articulatory organs based on acoustic analysis of speech
Novotný, Kryštof ; Galáž, Zoltán (referee) ; Mekyska, Jiří (advisor)
Hypokinetic dysarthria is a motor speech disorder often present during Parkinson’s disease. It affects the speech system, including articulatory abilities. There are several speech parameters describing this domain, so it is suggested to deal with their mutual comparison. This work aims to design and describe an algorithm for calculating the parameters of articulation, adapted for the Czech language, and then compare their discriminative power. The acoustic analysis of speech included in it is done via the Praat program and basic machine learning algorithms such as Expectation-Maximization, Kmeans and linear regression are used for the subsequent data processing. The Mann-Whitney U test and representatives of linear, nonlinear and ensemble machine learning models using cross-validation and balanced accuracy are used for evaluation. The results are scripts for automatic assessment of vowel space area, for calculating articulation parameters and for their evaluation. The outputs of the analysis of two different databases (PARCZ and CoBeN) prove that differences in articulation can indeed be observed between normal and dysarthric speech. Based on the mutual comparison of results, it is therefore proposed in the work which parameters and models of machine learning are being appropriate for further dealing with this issue.
Identification Of Parkinson’S Disease Using Acousticanalysis Of Poem Recitation
Mucha, Ján
Parkinson’s disease (PD) is the second most frequent neurodegenerative disorder. It is estimated that 60–90% of PD patients suffer from speech disorder called hypokinetic dysarthria (HD). The goal of this work is to reveal influence of poem recitation on acoustic analysis of speech and propose concept of Parkinson’s disease identification based on this analysis. Classification methods used in this work are Random Forests and Support Vector Machine. The best achieved accuracy of disease identification is 70.66% with 59.25% sensitivity for Random Forests classifier fed mainly with articulation features. These results demonstrate a high potential of research in this area.

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