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Radiation incidents at selected radiologic workplaces - the analysis of repeated images due to wrong irradiation of pacient.
ZÁKOUTSKÁ, Eliška
The thesis derives from the needs of institutions using sources of ionizing radiation to implement a new legislative regarding nuclear law, effective since 1st January 2017. The thesis is focused on radiological events at radiological institutions of chosen healthcare facilities. The theoretical part makes the reader familiar with the term "radiological event", generally elaborates on the field of diagnostic radiography and radiation protection. The practical part of the thesis deals with evaluation of the most occurring causes and the frequency of radiological events, obtained from the records of medical irradiation, even of wrongly carried out exposures in chosen diagnostic radiography institutions and wrongly sorted radiological events to a relevant category. To fulfil all the goals of the master thesis and to apply the results of the work in practice, also the contents of following document were evaluated - "Evaluation of the means of radiation protection", which every holder of permission to work with ionizing radiation has to submit to the SŮJB yearly, till 30th April, with the data from the previous year. This rule is valid since the new nuclear law was adopted. The results of this thesis served the chosen institution to create such report till 30th April 2019, with a broader extent of the analysis and evaluation than last year. The maximal detail of the report about causes and frequency of radiological events and mapping the real situation at the facilities serves also to the State Office for Nuclear Safety (SONS) to create a Recommendation of the SONS regarding the radiological events. Equally, the thesis was beneficial to the observed facilities, to realise the causes and frequency of radiological events in individual years. It is then up to an individual institution and to the employee supervising the radiation protection, to evaluate the consequences of the found causes, for example to point them out within a yearly training of radiation employees, and to consistently see to the compliance of all preventive measures, which proposal and implementation also belongs to the main tasks of the supervisor.
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Radiolabelled antibodies - the perspective for diagnosis and therapy
Mejtská, Jana ; Bárta, Pavel (advisor) ; Ramos Mandíková, Jana (referee)
1 CHARLES UNIVERSITY FAKULTY OF PHARMACY IN HRADEC KRÁLOVÉ DEPARTMENT OF BIOPHYSICS AND PHYSICAL CHEMISTRY DISSERTATION THESIS RADIOLABELED ANTIBODIES - THE PERSPECTIVE FOR DIAGNOSIS AND THERAPY Supervizor: Mgr. PAVEL BÁRTA, Ph.D. HRADEC KRÁLOVÉ, 2017 Bc. JANA MEJTSKÁ 2 ABSTRACT EN Different types of tissues have a characteristic cell morphology. Each cell has typical molecules on its surface, which may be either of physiological or pathological type. The presence of these surface structures can be interesting for possible modulation of specific cell populations from neighboring cells. Utilization of this property is then essential particularly in a case of tumor cells. Targeting on tumor specific cell structures involves the use of receptor specific peptides or monoclonal antibodies. The discovery of the preparation of monoclonal antibodies has opened a new chapter in the treatment and diagnosis not only tumor diseases. The advantage of monoclonal antibodies is their specificity and also high affinity to the type of the target cell structures. This study is focused on the summary of monoclonal antibodies which are currently being applied on the treatment or diagnosis of a particular cancer. Furthermore, this work also includes antibodies which are under development for intended medical applications with...
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