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Molecular aspects of calcium-phosphate metabolism in renal complications of diabetes mellitus.
Šimáková, Eva ; Černá, Marie (advisor) ; Zajíčková, Kateřina (referee)
Introduction: This thesis deals with the calcium-phosphate metabolism and its role in the development of chronic diabetic complications. It examines calcium sensitive receptor, which can be crucial in affecting calcium metabolism. Calcium-sensitive receptor may play a role in intracellular signaling and metabolic pathways that lead to cell proliferation and extracellular matrix early diabetic nephropathy. We investigated two polymorphisms of the gene for calcium-sensitive receptor (intron 4 and codon 990). Material and Methods: The study included 313 diabetic patients, 41 patients with type 1 diabetes, 106 patients with type 2 diabetes, 110 diabetic patients with type 2 diabetes who had diabetic nephropathy and 56 patients with renal failure non-diabetic (NDRD). It was also examined 72 non-diabetic patients with chronic renal failure (CKD) and 96 healthy blood donors (ZK). Classification of diagnoses is listed in the theory. DNA was isolated by QIAamp DNA Blood Mini Kit and salting method. The specific fragments of gene for the CaSR were amplified by PCR. For detection, restriction fragment length polymorphism and TaqMan probes were used. The expression levels of mRNA were determined by real-time PCR. Results: For the codon 990 polymorphism, we found statistical significance of the genotype frequencies (AA,...
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Creative use of digital technologies in literary education
Zajíčková, Kateřina ; Šindlerová, Jana (advisor) ; Králíková, Andrea (referee)
Digital applications may serve as tools for making the content of literary education more attractive and for developing pupils' competences, creativity and flexible thinking. Therefore, the aim of this mainly practically oriented work is to explore the didactic potential of selected digital applications in literary education and literary communication. In the theoretical part, we first present both the disciplinary background of our work and the existing knowledge on the use of digital technologies in education, including the main opportunities and risks that these technologies can bring to the educational environment. The practical, more extensive part contains a description of selected specific digital applications suitable for use in literary education classes, for which we evaluate both their didactic potential and the demands on the digital competence level of the user-educator. Finally, the creation of our own digital resources with sample methodologies is also included in the thesis.
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Vertical, temporal and sound constants in the Karolína Světlá's novel Kříž u potoka
Zajíčková, Kateřina ; Vaněk, Václav (advisor) ; Heczková, Libuše (referee)
The main purpose of submitted thesis is the complex analysis and interpretation of the novel Kříž u potoka (The Cross at the Stream) written by Czech female writer Karolína Světlá. The thesis brings several new perspectives how to construe this literary work and perceive its inanimate components as a mediator of the plot or as it's direct participant. Interpretation is demonstrated on three most significant constants which are present in the storyline - vertical space, time and sound as well. However, the author also outlines another options of viewing this literary work through different marginal perspectives. The result of this thesis should be the broad analysis of the text, which would bring its comprehensive picture from dissimilar points of view.
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Molecular aspects of calcium-phosphate metabolism in renal complications of diabetes mellitus.
Šimáková, Eva ; Černá, Marie (advisor) ; Zajíčková, Kateřina (referee)
Introduction: This thesis deals with the calcium-phosphate metabolism and its role in the development of chronic diabetic complications. It examines calcium sensitive receptor, which can be crucial in affecting calcium metabolism. Calcium-sensitive receptor may play a role in intracellular signaling and metabolic pathways that lead to cell proliferation and extracellular matrix early diabetic nephropathy. We investigated two polymorphisms of the gene for calcium-sensitive receptor (intron 4 and codon 990). Material and Methods: The study included 313 diabetic patients, 41 patients with type 1 diabetes, 106 patients with type 2 diabetes, 110 diabetic patients with type 2 diabetes who had diabetic nephropathy and 56 patients with renal failure non-diabetic (NDRD). It was also examined 72 non-diabetic patients with chronic renal failure (CKD) and 96 healthy blood donors (ZK). Classification of diagnoses is listed in the theory. DNA was isolated by QIAamp DNA Blood Mini Kit and salting method. The specific fragments of gene for the CaSR were amplified by PCR. For detection, restriction fragment length polymorphism and TaqMan probes were used. The expression levels of mRNA were determined by real-time PCR. Results: For the codon 990 polymorphism, we found statistical significance of the genotype frequencies (AA,...
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Specificity in the nursing for famous personalities, which are known through media
Zajíčková, Kateřina ; Haškovcová, Helena (advisor) ; Holmerová, Iva (referee)
This presented master's thesis deals the nursing of the famous personalities in the health care organisation. This thesis has got two chapters. The first is called Literature part, and deals with the history of nursing of famous people, explanation of terms medialy famous person. Famous persons are dividet by their profession. Firstly is presented personal protection, sensitive data of the patient, which is famed person. Afterwards is stated possible and real media impact and are disscused the possibilities of the protection in the health care sector. More detailed is describe nursing dilema, from patient point of view as well as health care providers. The probleme with undertreatment and overtreatment is also sensitive and that is why the reasonable attention is dedicated to VIP syndrome. The second part of my masters thesis is practical. Trought the quantitative and qualitative research was detected the real situation in the Rehabilitation clinic Malvazinky in Prague. The questionaire, focus group and interviews with observation were used. The opinion of health care providers was completed with the opinion of medial famous personalities. The research has shown that medial knowness of patient affected health care providers behaviour and nursing care. Onward follow on from research, that nursing care of...
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The use of grants to fund in kindergarten
ZAJÍČKOVÁ, Kateřina
The main purpose of my thesis is to describe how the kindergartens in the South Bohemian region source from the European Union grant. The theoretical part of my thesis contains the topic of the financing in education in general and the budget of the educational organization as well. I will also focus on the European Union funds and its division. Finally the topic of the grants from the Regional office of the South Bohemian region will be discussed. The task of the practical part is the sort out how the grants from the European Union are used and in case they are used only scarcely, my interest is to find out why. My thesis also consists of my own application for the grant which might be used in case the certain grant was announced.
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