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The influence of antidepressants on serotonin homeostasis in placenta
Váchalová, Veronika ; Štaud, František (advisor) ; Jirkovský, Eduard (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Veronika Váchalová Supervisor: Prof. PharmDr. František Štaud, Ph.D. Consultant: Mgr. Rona Karahoda Title of diploma thesis: The influence of antidepressants on serotonin homeostasis in placenta Depression is a serious mental disorder affecting 10-20% of women during pregnancy. Up to 10% of these pregnant women are prescribed antidepressants (ADs), most frequently from the class of selective serotonin (5-HT) reuptake inhibitors (SSRIs). While the safety of this treatment is questionable due to reported impaired pregnancy/fetal outcomes, understanding of potential mechanistic causes is still lacking. During pregnancy, 5-HT is important for normal placental function and proper fetal development and programming. 5-HT homeostasis in the placenta is maintained via the 5-HT transporter (SERT/SLC6A4) on the apical side and the recently characterized organic cation transporter 3 (OCT3/SLC22A3) on the basal side of trophoblast. These transporters take up 5-HT from the maternal and fetal circulations, respectively into the syncytiotrophoblast (STB) where it is degraded by monoamine oxidase-A (MAO-A). As all ADs interfere with the 5-HT system it is important to study their potential interactions in the...
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The influence of antidepressants on serotonin homeostasis in placenta
Váchalová, Veronika ; Štaud, František (advisor) ; Jirkovský, Eduard (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Veronika Váchalová Supervisor: Prof. PharmDr. František Štaud, Ph.D. Consultant: Mgr. Rona Karahoda Title of diploma thesis: The influence of antidepressants on serotonin homeostasis in placenta Depression is a serious mental disorder affecting 10-20% of women during pregnancy. Up to 10% of these pregnant women are prescribed antidepressants (ADs), most frequently from the class of selective serotonin (5-HT) reuptake inhibitors (SSRIs). While the safety of this treatment is questionable due to reported impaired pregnancy/fetal outcomes, understanding of potential mechanistic causes is still lacking. During pregnancy, 5-HT is important for normal placental function and proper fetal development and programming. 5-HT homeostasis in the placenta is maintained via the 5-HT transporter (SERT/SLC6A4) on the apical side and the recently characterized organic cation transporter 3 (OCT3/SLC22A3) on the basal side of trophoblast. These transporters take up 5-HT from the maternal and fetal circulations, respectively into the syncytiotrophoblast (STB) where it is degraded by monoamine oxidase-A (MAO-A). As all ADs interfere with the 5-HT system it is important to study their potential interactions in the...
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Analysis of Holstein dairy cow breeding
Váchalová, Veronika ; Toušová, Renata (advisor) ; Ducháček, Jaromír (referee)
The bachelor thesis deals with the breeding of Holstein dairy cattle within the system of intensive agriculture. The first chapters summarise the history of the breed, its origins and utilitarian purpose. The following chapters describe the systems of stabling, feeding and milking. The main factors affecting the economy include the quality and production of milk, as well as reproduction of dairy cows.
The practical part is engaged in the evaluation of reproduction and milk production at the farm in Tlumačov, which belongs under the Mrákov collective farm in the district of Domažlice. The farm had 239 cows of the Holstein breed in 2015. Their results were evaluated on the basis of milk utility control sheets for the period from 1st January 2015 to 31st December 2015. I divided the monitored herd into 3 groups: cows in the 1st, 2nd and 3rd lactation. I focused on the comparison of the total milk yield, milk fat content, protein percentage and number of somatic cells in all three groups. The results showed that the average milk yield of the entire herd for 2015 was 10,064 kg with an average fat content of 384 kg (3,81%) and milk protein content of 328 kg (3,26 %). As for the number of somatic cells, the average value 130,000/ml achieved by the farm in Tlumačov is very good. The best results were achieved by cows in the 1st lactation, with the average value of 70,000/ml. Their milk therefore is in compliance with the highest quality requirements.
Reproduction was evaluated by basic parameters. The results showed that gravidity after the first insemination reached satisfactory values for heifers as well as cows. Although the service period was shorter than optimal, according to various literary sources it is tolerable. The insemination index for heifers was evaluated as very good. Cows also achieved a good result in this parameter in 2015.
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