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Post-vaccination response in patients with diGeorge syndrome
Petříčková, Michaela ; Skalická, Anna (advisor) ; Šedivá, Anna (referee)
DiGeorge syndrome is an autosomal dominantly inherited disease with an incidence of 1: 4 000. Its distinctive phenotypic manifestations are collectively referred to as CATCH 22. Its holders can cause serious clinical problems. One of the primary syndrome congenital deficits of cellular immunity from an immunological point of view. According to the severity of immunodeficiency DiGeorge syndrome can distinguish complete and partial. Patients due to improper development of thymic T cell immunity has affected. The work deals with the humoral immunity of patients with DiGeorge syndrome, which should theoretically not be affected. It is mainly focused on post-vaccination antibodies and their dynamics, and immunoglobulins A, G, E and M. Monitoring patients from the database of patients with DiGeorge syndrome examined at the Institute of Immunology, 2nd Charles University Medical Faculty and University Hospital Motol in the years 1995 - 2011 shows that post-vaccination response in DiGeorge syndrome is not significantly affected. Abnormal levels of immunoglobulins were observed fundamental observed.
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Music in the personal development of a younger toddler
Skalická, Anna ; Kodejška, Miloš (advisor) ; Váňová, Hana (referee)
The diploma thesis describes the importance of music in the personal development of a younger toddler. The theoretical part deals with an insight into the personality development of the child from the prenatal period to the period of a younger toddler. It also deals with the characteristics of the imprinting and sensitive period in the child's life, the influence of music on the development of the toddler's personality, musical development and the development of musical abilities in this period. It also discusses the importance of a musically stimulating environment for the development of the child's personality and presents artistic themes for early children in an integrated approach. The practical part of the diploma thesis is based on monitoring and evaluating the musical expressions of my son and seven children examined throughout the period of the younger toddler. The aim of this diploma thesis is to monitor the musical development of the younger toddler and the physical, mental and sociological influences that affect the personal development of the toddler through music. As part of the qualitative research, interviews were also conducted with mothers of seven younger toddlers, which serve to supplement the results of monitoring the development of children's music in this period. Furthermore,...
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Post-vaccination response in patients with diGeorge syndrome
Petříčková, Michaela ; Skalická, Anna (advisor) ; Šedivá, Anna (referee)
DiGeorge syndrome is an autosomal dominantly inherited disease with an incidence of 1: 4 000. Its distinctive phenotypic manifestations are collectively referred to as CATCH 22. Its holders can cause serious clinical problems. One of the primary syndrome congenital deficits of cellular immunity from an immunological point of view. According to the severity of immunodeficiency DiGeorge syndrome can distinguish complete and partial. Patients due to improper development of thymic T cell immunity has affected. The work deals with the humoral immunity of patients with DiGeorge syndrome, which should theoretically not be affected. It is mainly focused on post-vaccination antibodies and their dynamics, and immunoglobulins A, G, E and M. Monitoring patients from the database of patients with DiGeorge syndrome examined at the Institute of Immunology, 2nd Charles University Medical Faculty and University Hospital Motol in the years 1995 - 2011 shows that post-vaccination response in DiGeorge syndrome is not significantly affected. Abnormal levels of immunoglobulins were observed fundamental observed.
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Immunity in children with cystic fibrosis
Skalická, Anna ; Šedivá, Anna (advisor) ; Průcha, Miroslav (referee)
Cystická fibróza (CF) je závažné autozomálně recesivně dědičné onemocnění způsobené mutací genu CFTR (Cystic Fibrosis Transmembrane Conductance Regulator), který se nachází na dlouhém raménku 7. chromozomu (1). Uváděný výskyt CF je v bělošské populaci jeden případ na 2. 500 narozených dětí. Chorobu způsobují mutace CTFR genu, který ovlivňuje funkci odpovídajícího proteinu a následnou nefunkčnost membránových i iontových kanálů v postižených buňkách. V důsledku poruchy regulace iontového transportu na membránách epiteliálních buněk se mění složení a fyzikálně chemické vlastnosti na povrchu sliznic. Hlenový sekret na povrchu epitelu se zahušťuje a narušená funkce orgánů je příčinou většiny klinických příznaků CF. Onemocnění dýchacích cest a plic je nejzávažnějším projevem CF. Určuje průběh a prognózu a zodpovídá za 90% úmrtí na tuto chorobu. Pacienti s CF trpí chronickými, nejčastěji bakteriálními, respiračními infekcemi. Nejzávažnější jsou infekce způsobené Gram negativními tyčemi Pseudomonas aeruginosa a bakteriemi komplexu Burkholderia cepacia. Eradikace těchto patogenů při chronické infekci prakticky není možná a velká pozornost je věnována mechanismům, které zvyšují patogenicitu těchto mikroorganismů, nicméně uspokojivé vysvětlení chronické perzistence bakteriální infekce právě těmito specifickými...
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Fulfilment of selected goals analysis of international organization ASEAN
Skalická, Anna ; Kochan, Jan (advisor) ; Volenec, Otakar (referee)
This bachelor thesis aims to measure fulfilment level of chosen goals, defined in foundation documents of international organization ASEAN. The main goal of this thesis is to measure the level of fulfilment of each chosen goal and find out, whether or not ASEAN functions effectively. Thesis is divided into three parts. First, it outlines international organization theory, applies it to the case of ASEAN and suggests some ways to measure effectiveness of international organizations. In second, practical part, thesis analyses fulfilment of five chosen economic, political and development goals. Finally, thesis measures the effectiveness of ASEAN's activity, using the findings from practical part. According to the chosen methodology, ASEAN seems to be a quite effective international organization, which is especially successful in the political domain. It has already achieved partial accomplishments in the development and economical areas, although still has broad improvement opportunities in the latter.
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