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Nasal polyposis and quality of life
Hančík, Martin ; Schalek, Petr (advisor)
In 10 years, suffered an accident in the fall of the face of the hatch channel. massive bleeding nasal tamponade was built only in their domestic cold compresses. accident ORL has not been revised or another doctor . At 16, she began to discover problems with nasal throughput , but which from the beginning has been paid no more attention. also the impaired nasal patency accompanied by increased nasal secretion. These problems are solved overuse of nasal decongestive sprays. But after about a year he began to have problems with insomnia to sleep . She attacked him possibly related to the use of otorinolaryngologik and after read the possible side effects of nasal sprays decided to stop. And just at that time he use of nasal sprays had the desired effect such as the beginning of a frequency between individual jets already so short, that one bottle of nasal spray him enough for a 2 days. He got used to breathing more oral. After some time the breathing ratios improve and was for some time "No problem ." In this so-called problem-free periods have been episodes where he suffered long- term subfebrile , where the search for the cause but not because Mr. M. thought that if was something more serious , so he would not have a fever. He also continuously shaped pins the tonsils , which , although it does not...
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Therapy and prevention recurrence of nasal polyposes
Votavová, Dominika ; Schalek, Petr (advisor)
Nosní polypóza je sice onemocněním benigním, ale výrazně ovlivňuje kvalitu života. Zdá se, že není onemocněním per se, ale že se spíše jedná o výsledek nebo o vyjádření chronických zánětlivých procesů probíhajících na sliznici dutiny nosní a VDN. Patogeneza NP zůstává přesto neznámá. Prevalence výskytu Staphylococcus aureus u pacientů s nosní polypózou je vysoká. Nové studie prokázaly výskyt IgE protilátek ve tkáni polypu, zaměřených proti stafylokokovým enterotoxinům (SAE). Avšak role Staphylococcus aureus v rozvoji tohoto onemocnění je s největší pravděpodobností minimální. Za základ terapie považujeme lokální kortikosteroidy. Při neúspěchu nebo rozsáhlé nosní polypóze se velmi často uchylujeme k chirurgickému řešení. Nejčastěji prováděnou operací nosní polypózy je FES. V naší studii jsme se zabývali vlivem pooperační terapie antibiotiky u pacientů po prodělané FES. Výsledkem studie byl negativní nález na kultivaci pro SA u 30% pacientů, nezávisle na tom, zda pacienti dostávali pooperačně placebo nebo ATB. Je tedy pravděpodobné, že samotná přítomnost polypu podporuje kolonizaci Staphylococcus aureus.
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Prevention of nasal polyposis
Nesvadbová, Martina ; Schalek, Petr (advisor)
Rhinosinusitis is a heterogeneous group of diseases, with different underlying etiologies and pathomechanisms, and may indeed represent an umbrella, covering different disease entities. It is currently not understood whether acute recurrent rhinosinusitis necessarily develops into chronic rhinosinusitis, which then possibly gives rise to polyp growth, or whether these entities develop independently from each other. Nasal polyposis is an inflammatory condition that affects from 1% to 4% of the general population. Polyposis is believed to be multifactorial disease that is frequently associated with asthma and aspirin sensitivity. The studies show that more polyps were found in nonatopic that in atopic patients. A global evaluation of NP must include, together with nasal endoscopy, symptoms assessment, and CT-scan, the measurement of the quality of life. In my study I used the Sino nasal outcome test (SNOT-22), with 22 questions to ask the patients about the quality of life. They were asked to fill up the questionnaire before and 6 month after the surgical procedure. Twelve patients were included to this study, than they were divided into two groups, patients with and without the factors of the risk (asthma, aspirin sensitivity and allergy). I compared the scores of two groups by using an impaired Student t...
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Prevention of recurrent nasal polyposis in patients with detection of enterotoxi n producing Staphylococcus aureus strains
Schalek, Petr ; Petráš, Petr (advisor) ; Julák, Jaroslav (referee) ; Malina, Jiří (referee) ; Vokurka, Jan (referee)
Enterotoxins produced by Staphylococcus aureus can act as superantigens and thus, regardless of the antigenic specificity, influence the course of chronic rhinosinusitis with nasal polyps (NP). The aim of this study was to determine if antibiotic treatment administered after endoscopic sinus surgery (ESS) for NP can positively influence the course of the disease compared to placebo. After ESS, 23 patients which tested positive, in a perioperative culture, for SA strains producing enterotoxins A - E and TSST-1, were randomized into 2 groups. Group A (13 patients), which in addition to treatment with intranasal steroids and saline douches, received oral anti-staphylococcal antibiotics (according to the minimal inhibitory concentration) for 3 weeks. Group B (10 patients) received a placebo. Both groups were compared preoperatively, then again at 3 and 6 months after surgery using a symptom-specific score, an endoscopic score and the SNOT-22 quality of life questionnaire. Slightly better results were achieved in patients who received antibiotic therapy. However, the differences were not statistically significant. The biggest difference was seen on the endoscopic score 3 months after surgery. This difference clearly favored patients in group A. Regardless of post-operative treatment, approximately 30 % of...
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Impact of pharyngofixation and timing in cleft palate repair surgery on the development of chronic adhesive otitis media and cholesteatoma in cleft palate patients.
Otruba, Lukáš ; Schalek, Petr (advisor) ; Klačanský, Juraj (referee) ; Hahn, Aleš (referee)
Introduction: A significant number of pediatric cleft patients suffer from OMS and its consequences as hearing loss, adhesive retraction changes and cholesteatoma. The aim of our retrospective study was to find out whether these effects can be minimized by selecting an operative technique to correct the palate - using pharyngofixation or by surgery timing . Material and methods: Retrospective study involving163 patients - 325 ears (1x external auditory canal atresia), operated at the age of 5 months - 8 years, follow up time 36-84 months. Results: 125 (38%) ears had an epitympanic retraction and 45 (14%) had a superior posterior quadrant retraction, 10 (3%) had cholesteatoma, together 5 epitympanic and 5 sinus cholesteatoma. No significant relationship was found between the use of pharyngofixation and the severity of the otologic finding, respectively of retraction rates in the epitympanum and the posterior superior quadrant (p 0.53). Analogous no significant relationship was found between the surgery timing and the severity of the otologic finding (p 0.48) Conclusion: In our findings, the use of pharyngofixation and timing of palate correction surgery is not related with the severity of subsequent otologic findings. According to our experience and in accordance with the literature, the best...
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Prevention of recurrent nasal polyposis in patients with detection of enterotoxi n producing Staphylococcus aureus strains
Schalek, Petr ; Petráš, Petr (advisor) ; Julák, Jaroslav (referee) ; Malina, Jiří (referee) ; Vokurka, Jan (referee)
Enterotoxins produced by Staphylococcus aureus can act as superantigens and thus, regardless of the antigenic specificity, influence the course of chronic rhinosinusitis with nasal polyps (NP). The aim of this study was to determine if antibiotic treatment administered after endoscopic sinus surgery (ESS) for NP can positively influence the course of the disease compared to placebo. After ESS, 23 patients which tested positive, in a perioperative culture, for SA strains producing enterotoxins A - E and TSST-1, were randomized into 2 groups. Group A (13 patients), which in addition to treatment with intranasal steroids and saline douches, received oral anti-staphylococcal antibiotics (according to the minimal inhibitory concentration) for 3 weeks. Group B (10 patients) received a placebo. Both groups were compared preoperatively, then again at 3 and 6 months after surgery using a symptom-specific score, an endoscopic score and the SNOT-22 quality of life questionnaire. Slightly better results were achieved in patients who received antibiotic therapy. However, the differences were not statistically significant. The biggest difference was seen on the endoscopic score 3 months after surgery. This difference clearly favored patients in group A. Regardless of post-operative treatment, approximately 30 % of...
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The prevention of postoperative recurrences of nasal polyposis
Rousková, Jana ; Schalek, Petr (advisor)
Diseases of the nose and paranasal sinuses was until recently rather the outskirts of interest otorinolaringologů a separate professional publication devoted only nasal polyposis was published in England in the year 1997. V Rhinology occurred for the last decade, the rapid development of interest in nasal polyposis , her surgery, Conservative therapy, relapse prevention and course of the disease. Recently discovered new surgical and conservative therapies and obvious relationship to serious diseases of the lower respiratory tract . Nasal polyposis , although it is a benign disease , the patients subjectively perceived as very unpleasant and unfortunately often recurrent disease. Nasal polyps are a manifestation of pathological changes in the respiratory mucosa upper respiratory tract. There are many different definitions of the disease and on the basis of these expert opinion can be used for the definition : Nasal polyps are edematous mucosa pouches , occurring to different extents from one polyp to diffuse polyposis . May affect the nasal cavity , paranasal cavity but also . generally said that nasal polyposis is the final stage of the chronic inflammatory process nasal mucosa of various causes , but the etiology and pathogenesis of nasal polyposis is not Currently clearly elucidated. Polyps occur as often...
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Nasal polyposis and quality of life
Hančík, Martin ; Schalek, Petr (advisor)
In 10 years, suffered an accident in the fall of the face of the hatch channel. massive bleeding nasal tamponade was built only in their domestic cold compresses. accident ORL has not been revised or another doctor . At 16, she began to discover problems with nasal throughput , but which from the beginning has been paid no more attention. also the impaired nasal patency accompanied by increased nasal secretion. These problems are solved overuse of nasal decongestive sprays. But after about a year he began to have problems with insomnia to sleep . She attacked him possibly related to the use of otorinolaryngologik and after read the possible side effects of nasal sprays decided to stop. And just at that time he use of nasal sprays had the desired effect such as the beginning of a frequency between individual jets already so short, that one bottle of nasal spray him enough for a 2 days. He got used to breathing more oral. After some time the breathing ratios improve and was for some time "No problem ." In this so-called problem-free periods have been episodes where he suffered long- term subfebrile , where the search for the cause but not because Mr. M. thought that if was something more serious , so he would not have a fever. He also continuously shaped pins the tonsils , which , although it does not...
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Prevention of nasal polyposis
Nesvadbová, Martina ; Schalek, Petr (advisor)
Rhinosinusitis is a heterogeneous group of diseases, with different underlying etiologies and pathomechanisms, and may indeed represent an umbrella, covering different disease entities. It is currently not understood whether acute recurrent rhinosinusitis necessarily develops into chronic rhinosinusitis, which then possibly gives rise to polyp growth, or whether these entities develop independently from each other. Nasal polyposis is an inflammatory condition that affects from 1% to 4% of the general population. Polyposis is believed to be multifactorial disease that is frequently associated with asthma and aspirin sensitivity. The studies show that more polyps were found in nonatopic that in atopic patients. A global evaluation of NP must include, together with nasal endoscopy, symptoms assessment, and CT-scan, the measurement of the quality of life. In my study I used the Sino nasal outcome test (SNOT-22), with 22 questions to ask the patients about the quality of life. They were asked to fill up the questionnaire before and 6 month after the surgical procedure. Twelve patients were included to this study, than they were divided into two groups, patients with and without the factors of the risk (asthma, aspirin sensitivity and allergy). I compared the scores of two groups by using an impaired Student t...
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Therapy and prevention recurrence of nasal polyposes
Votavová, Dominika ; Schalek, Petr (advisor)
Nosní polypóza je sice onemocněním benigním, ale výrazně ovlivňuje kvalitu života. Zdá se, že není onemocněním per se, ale že se spíše jedná o výsledek nebo o vyjádření chronických zánětlivých procesů probíhajících na sliznici dutiny nosní a VDN. Patogeneza NP zůstává přesto neznámá. Prevalence výskytu Staphylococcus aureus u pacientů s nosní polypózou je vysoká. Nové studie prokázaly výskyt IgE protilátek ve tkáni polypu, zaměřených proti stafylokokovým enterotoxinům (SAE). Avšak role Staphylococcus aureus v rozvoji tohoto onemocnění je s největší pravděpodobností minimální. Za základ terapie považujeme lokální kortikosteroidy. Při neúspěchu nebo rozsáhlé nosní polypóze se velmi často uchylujeme k chirurgickému řešení. Nejčastěji prováděnou operací nosní polypózy je FES. V naší studii jsme se zabývali vlivem pooperační terapie antibiotiky u pacientů po prodělané FES. Výsledkem studie byl negativní nález na kultivaci pro SA u 30% pacientů, nezávisle na tom, zda pacienti dostávali pooperačně placebo nebo ATB. Je tedy pravděpodobné, že samotná přítomnost polypu podporuje kolonizaci Staphylococcus aureus.
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