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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
Ghrelin in malnutrition of various etiologies Gherlin as a factor in the pathogenesis of systemic inflammatory response
 Rosická, Martina ; Marek, Josef (advisor) ; Stárka, Luboslav (referee) ; Vrbíková, Jana (referee)
Ghrelin, the endogenous ligand for the growth hormone secretagogue receptor, was discovered in 1999 by Kojima et al. (Kojima et al. 1999). Ghrelin is composed of 28 amino acids, with a unique octanoyl modification of hydroxygroup on serine at the 3rd position. This peptide modification is entirely unique to the organism and is essential for the function of this peptide (Bednarek et al. 2000). Ghrelin is predominantly produced by cells in the oxyntic mucosa of the stomach (Date et al. 2000). According to the widespread distribution of the peptide and its receptor ghrelin has multiple biological effects. Ghrelin is a strong stimulator of the growth hormone secretion in the somatotroph cells of hypophysis (Takaya et al. 2000, Peino et al. 2000), plays an important role in signaling hypothalamic centers regulating feeding and caloric state (ghrelin leads to an increase of the food intake and a decrease of the energy expenditure) (Nakazoto et al. 2001). Its orexigenic effects are independent of growth hormone stimulation and appear to be mediated at least in part through activation of NPY/agouti gene-related protein neurons in the hypothalamic arcuate nucleus. The aim of our study is to demonstrate the change of active and total ghrelin in malnourished patient and during systemic inflammatory response and their...
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3 Rosická, Markéta
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