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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Sexual dimorphism and skull morphology with regard to the social structure of the Great Moravian burial area Mikulčice
 Rieger, Vojtěch ; Bejdová, Šárka (advisor) ; Bigoni, Lucie (referee)
1 Abstract This diploma thesis deals with the influence of gender and socio-economic affinity on skull morphology in the population of Slavs from early medieval settlement Mikulčice. Mikulčice was the power center of Great Moravia with a hierarchically structured society. For a better understanding of historical relationships in the society at the time, it is important to identify individuals and classify them in the appropriate social group. There have been previously identified morphological differences of the skull between the inhabitants buried in the Mikulčice castle and those buried in the sub-castle area. These differences were related to the different living conditions based on the social status of the individuals buried in the castle and sub-castle area. This thesis studies whether there is a similar link between the individual's socio-economic affinity and the wealth of items found in graves. Furthermore, the influence of locality and burial equipment on skull morphology is compared with each other. Within the groups defined in this way, sexual dimorphism is also described, whose degree of manifestation, among other things, is related to the suitability of the external environment and is thus a convenient anthropological marker. A total of 89 individuals (40 women and 49 males) aged 20 to 60 years...
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Molecular basis of phenotypic variability in male and female patients with Fabry disease
 Rieger, Vojtěch ; Dvořáková, Lenka (advisor) ; Rothová, Olga (referee)
Fabry disease is an X linked illness caused by mutation in the GLA gene which codes lysosomal enzyme α-galactosidase A. The defect of this enzyme leads to progressive storage of neutral glycosphigolipids in the lysosomes which has significant physiological implications. Fabry disease has very variable clinical manifestations because of the combination of many factors, yet not all of them are known. Even though heterozygotic women carry also a wild type allel, they are not asymptomatic. Their symptoms, however, are usually in a milder form. Due the random inactivation of one of the X gonosomes, there is a posibility of skewed X inactivation pattern, which may inflict an increase of symptoms on the disordered woman. Many studies concerning X inactivation have been published, however their conclusions were contradictory. The purpose of this work is to summarise the causes of fenotypic variability in hemizygotes and heterozygotes with skewed X inactivation.
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