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Attachement disorders predicted by ECR, case studies of teenager girls with addiction problems in institutional upbringing
Horváthová, Klára ; Libra, Jiří (advisor) ; Pešek, David (referee)
BACKGROUND: Attachment disorders have an impact on the future quality of interpersonal relationships and are related to disorders in adolescence, such as the tendency to engage in risky behaviour. Clients who are placed in the diagnostic institute and affiliated units have disturbed relationships and at the same time have been shown to exhibit risky behaviour. The family backgrounds from which clients come are often dysfunctional or disrupted, and attachment disorders may also play a role. OBJECTIVES: Determination of the percentage of attachment disorders in girls ordered into institutional care due to substance use and subsequent development of case studies for selected disorders predicted by the ECR (Experience of close relationships). Thus, the aim is to take a deeper look at the issue of attachment disorders and adolescent girls with ordered institutional education METHODS: Quantitative research - submission of a questionnaire survey to ECR and subsequent statistical evaluation Qualitative research: case studies of clients with proven attachment disorder in the form of semi-structured interviews. Discussion of data obtained in both parts of the research. RESULTS: Research has shown that attachment disorders are widespread in this target group. Some emotional attachment was assessed by the...
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A neural network for reconstruction of extinct animals
Pešek, David ; Bilík, Šimon (referee) ; Jirsík, Václav (advisor)
This work was focused on designing, learning and evaluating an artificial neural network for reconstructing extinct species. First, the main element of the proposed artificial neural network, i.e., the generative model, was selected. Given their excellent performance in the field of image generation, the class of diffusion models reasonably seemed to be the right choice. Specifically, the Stable diffusion model was chosen. One of the initial steps of the work was to create a training set for the proposed model. The animal images needed to be paired with some labels that could be used to identify the animal. For this purpose, the cytochrome c oxidase subunit I genes of the given animals were used. Furthermore, the sequential transformer model GPT-2, which is learned on the training set of human natural language, was used. This model was used to encode the DNA sequences into a vector form in which the semantics and context between the different parts of the DNA sequence were captured. The models would be very difficult to learn from scratch due to the large training set size required and the computational and time requirements. Thus, the GPT-2 model was only learned on the training set of DNA sequences of the passeriformes order, and the diffusion model itself was learned on pairs of images of these animals and DNA sequences encoded by the GPT-2 model. To generate the images, the original DNA sequences that resembled the sequences from the training set were generated using GPT-2. The encoding of these sequences was then passed to the diffusion model, which generated the images itself. The method of generating new DNA sequences using the GPT-2 model is based on the idea that the generated DNA sequence partially resembles the DNA sequences from the training set. Such experimentally generated DNA sequences may resemble DNA sequences of extinct ancestors or relatives of the passeriformes order. The model was in some cases able to generate images that could be considered as animal species , but it should be noted that often the generated images could not be considered as animal reconstructions. The success rate of generating a decent animal image was approximately 10%. The functionality of the model was also tested on a test set of DNA sequences of animals of several orders that fall under the class of birds as well as the order of passeriformes. The success rate of generating a reconstruction that could be compared to a photograph was around 5%.
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František Bílek- Life, work and the activity in CČSH
Pešek, David ; Hrdlička, Jaroslav (advisor) ; Lášek, Jan Blahoslav (referee)
This diploma thesis focuses upon František Bílek, a famous Czech sculptor. He was one of the key figures of the fin-de-siécle culture in the Czech countries. The text is divided into several chapters. The first one is called Life and Work and it represents a basic overview of the themes dealt with in this thesis. The following chapter explores how Bílek's contemporaries, his friends or fellow artists including J. Zeyer or O. Březina, saw him. Next, there is the section examining Bílek's cooperation with Nový život and his relationships with Catholic modernism leaders such as K. Dostál-Lutinov or S. Bouška. There follows the chapter about his collaboration with the Czechoslovak Hussite Church, where the work that Bílek and his family did for the Church is described. Finally, the chapter The Ideal World of František Bílek focuses on his theology, philosophy and works of art that were influenced by mysticism. At the end of the work, there are several illustrations of various Bílek's pieces added.
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The noncoding control region of human polyomaviruses
Pešek, David ; Saláková, Martina (advisor) ; Váňová, Jana (referee)
Genome of human polyomavirus consists of circular dsDNA around 5000 base and can be divided into three functional regions - the early viral gene region (EVGR), that encodes the regulatory T antigen and miRNAs, noncoding control region (NCCR) harboring the minimal cis- acting elements involved in viral replication and the late viral gene region (LVGR), that encodes the structural capsid proteins. Noncoding control region contains the origin of viral replication that overlaps the promoters that control expresion of early and late gene region. Noncoding control region sequences include a large number of various binding sites for cellular transcription factors involved in regulation expression from LVGR and EVGR. This thesis describes the organization of the most variable region of the PyV genome, NCCR, in chosen polyomaviruses SV40, BKPyV and JCPyV. This region often undergoes rearrangements, deletion and point mutations that affects exression of human polyomavirus. Key words: polyomavirus, noncoding control region, BKPyV virus, JCPyV virus, SV40, large T antigen, transcriptional factor
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František Bílek- Life, work and the activity in CČSH
Pešek, David ; Hrdlička, Jaroslav (advisor) ; Lášek, Jan Blahoslav (referee)
This diploma thesis focuses upon František Bílek, a famous Czech sculptor. He was one of the key figures of the fin-de-siécle culture in the Czech countries. The text is divided into several chapters. The first one is called Life and Work and it represents a basic overview of the themes dealt with in this thesis. The following chapter explores how Bílek's contemporaries, his friends or fellow artists including J. Zeyer or O. Březina, saw him. Next, there is the section examining Bílek's cooperation with Nový život and his relationships with Catholic modernism leaders such as K. Dostál-Lutinov or S. Bouška. There follows the chapter about his collaboration with the Czechoslovak Hussite Church, where the work that Bílek and his family did for the Church is described. Finally, the chapter The Ideal World of František Bílek focuses on his theology, philosophy and works of art that were influenced by mysticism. At the end of the work, there are several illustrations of various Bílek's pieces added.
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