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Structural and functional impacts of infective endocarditis
Pazderník, Michal ; Šochman, Jan (advisor) ; Veselka, Josef (referee) ; Beneš, Jiří (referee)
Despite more recent advances in both medical and surgical therapies, the syndrome of infective endocarditis (IE) continues to be characterized by serious complications, and remains a life-threatening infection. According to data from the World Health Organization, the Czech Republic has one of the highest mortality rates due to this disease worldwide. Despite the severity of illness in this country, very few data have been reported previously regarding investigations of IE in the Czech Republic. Consequently, a retrospective evaluation of local IE cases at one of the country's largest medical centers was conducted. Our aim was to analyze the characteristics of this disease in our country. The greatest interest was devoted to Staphylococcus aureus (S. aureus), etiological agent that has been associated with the worst course of IE episodes. The hypothesis of our study was that infective endocarditis caused by S. aureus, in comparison with other etiological agents, is associated with worse course of the disease. We evaluated the structural (abscess formation, impaired integrity of heart valves, systemic embolism) and functional (incidence of heart failure and conduction disturbances, in-hospital mortality) manifestations of IE. Of all studied parameters, only embolism and S. aureus as the causative agent were...
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Clinical Manifestations of Infective Endocarditis Depending on Infectious Agent
Pazderník, Michal ; Vojáček, Jan (advisor) ; Táborský, Miloš (referee) ; Vítovec, Jiří (referee)
Introduction: Despite more recent advances in both medical and surgical therapies, the syndrome of infective endocarditis (IE) continues to be characterized by serious complications, and remains a life-threatening infection. According to data from the World Health Organization, the Czech Republic has one of the highest mortality rates due to this disease worldwide. Aims and methods: A study of local IE cases was conducted in two leading Cardiac centres in the Czech Republic. The main objective was to analyse the features of this disease and, at the same time, to identify predictors that are associated with the development of acute complications and worse survival of patients with IE. Results: Infection of the aortic prosthesis was a significant predictor of paravalvular spread of infection (OR 6.706). Infection caused by Staphylococcus aureus (OR 8.459) and smoking (OR 8.403) were associated with a more frequent development of septic shock (OR 8.403). The most potent risk factors of possible embolization were mitral valve vegetation ≥ 13 mm (OR 3.59) and IE caused by Staphylococcus aureus (OR 3.24). The size of the vegetation was not only associated with the risk of embolization itself but also with a local destructive effect in the form of a new prolapse/perforation of the valve (OR 1.055). The importance...
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Structural and functional impacts of infective endocarditis
Pazderník, Michal ; Šochman, Jan (advisor) ; Veselka, Josef (referee) ; Beneš, Jiří (referee)
Despite more recent advances in both medical and surgical therapies, the syndrome of infective endocarditis (IE) continues to be characterized by serious complications, and remains a life-threatening infection. According to data from the World Health Organization, the Czech Republic has one of the highest mortality rates due to this disease worldwide. Despite the severity of illness in this country, very few data have been reported previously regarding investigations of IE in the Czech Republic. Consequently, a retrospective evaluation of local IE cases at one of the country's largest medical centers was conducted. Our aim was to analyze the characteristics of this disease in our country. The greatest interest was devoted to Staphylococcus aureus (S. aureus), etiological agent that has been associated with the worst course of IE episodes. The hypothesis of our study was that infective endocarditis caused by S. aureus, in comparison with other etiological agents, is associated with worse course of the disease. We evaluated the structural (abscess formation, impaired integrity of heart valves, systemic embolism) and functional (incidence of heart failure and conduction disturbances, in-hospital mortality) manifestations of IE. Of all studied parameters, only embolism and S. aureus as the causative agent were...
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