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New synthetic drugs - neurobiology, toxicity and addictive potential
Leca, Nikola
Introduction: Since the beginning of this century, new synthetic drugs (NSD) have become a popular component of Czech Republic and worldwide drug scene. The main reason for their popularity and prevalence is their legality and the interest of users to seek new experiences. This leads to a constant production of substances with various chemical structure's modifications, but information about acute and chronic effects, pharmacology and toxicology are mostly missing or they are not sufficient. Aims: The main aim of this doctoral thesis was to evaluate NSD from the ranks of cathinones. The subobjectives were as follows: 1) evaluation of stimulation potential 2) evaluation of potency to disrupt sensorimotor gating 3) evaluation of acute toxicity in terms of the risk of hyperthermia 4) evaluation of addictive potential. Methods: The NSDs tested in this thesis were mephedrone (2.5, 5, 20 mg/kg), methylone 5, 10, 20, 40 mg/kg) and naphyrone (5, 10, 20 mg/kg). All NSDs were administered subcutaneously in a volume of 2 ml/kg. Adult male Wistar rats were behaviourally tested in the open field test (n = 10/group), the prepulse inhibition test (n = 10/group) and the conditioned place preference test (n = 13/group). For pharmacokinetic experiments, serum and organs (brain, lungs, liver) were collected at...
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New synthetic drugs - neurobiology, toxicity and addictive potential
Leca, Nikola ; Páleníček, Tomáš (advisor) ; Šlamberová, Romana (referee) ; Rečková Hroudová, Jana (referee)
Introduction: Since the beginning of this century, new synthetic drugs (NSD) have become a popular component of Czech Republic and worldwide drug scene. The main reason for their popularity and prevalence is their legality and the interest of users to seek new experiences. This leads to a constant production of substances with various chemical structure's modifications, but information about acute and chronic effects, pharmacology and toxicology are mostly missing or they are not sufficient. Aims: The main aim of this doctoral thesis was to evaluate NSD from the ranks of cathinones. The subobjectives were as follows: 1) evaluation of stimulation potential 2) evaluation of potency to disrupt sensorimotor gating 3) evaluation of acute toxicity in terms of the risk of hyperthermia 4) evaluation of addictive potential. Methods: The NSDs tested in this thesis were mephedrone (2.5, 5, 20 mg/kg), methylone 5, 10, 20, 40 mg/kg) and naphyrone (5, 10, 20 mg/kg). All NSDs were administered subcutaneously in a volume of 2 ml/kg. Adult male Wistar rats were behaviourally tested in the open field test (n = 10/group), the prepulse inhibition test (n = 10/group) and the conditioned place preference test (n = 13/group). For pharmacokinetic experiments, serum and organs (brain, lungs, liver) were collected at...
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Neurobiology and toxicity of new psychoactive substances from hallucinogens class
Zmátlo, Vít ; Leca, Nikola (advisor) ; Novotný, Jiří (referee)
Main focus of this thesis are the novel synthetic psychoactive substances from hallucinogens class. The first part expands the phenomenon of hallucinogens and describes its general mechanisms. Serotonergic system is emphasised with focus on 5-HT2A receptor as a main moderator of hallucinogenic aktivity. Next part enlightens the issue of new psychoactive substances and elaborates on two main classes of hallucinogens - tryptamines and phenylethylamines, with epmhasis on their synthetic derivates. There is described the form of occurence, relationship between chemical structure and biological activity, and current knowledge of neurobiology toxicity of those substances. Key words: New psychoactive substances, hallucinogens, serotonergic system, neurobiology, toxicity
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