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Long-term changes of selected stratospheric fields related to circulation and enhancing greenhouse effect
Kozubek, Michal ; Laštovička, Jan (advisor) ; Halenka, Tomáš (referee)
In the present work we study behavior and trends of stratospheric wind in period of 1957-2002. We used reanalyzed daily data from project ERA-40. Results are shown in graphic form for 3 atmospheric levels. In each level we describe trends of wind velocities and directions separate into 2 seasons. We also compare trends of stratospheric wind with other characteristic indicators of atmospheric circulation. One of them is total columnar ozone and the second is mesopause midlatitude winds. Results of analyze halving adjustment of trends in wind directions and velocities for level 100, 50 and 10 hPa, too.
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Vertical variability of the 11 years solar cycle influence within the middle and higher atmosphere
Kuchař, Aleš ; Pišoft, Petr (advisor) ; Laštovička, Jan (referee)
This work investigates changes implied by variability of temperature, zonal wind and ozone mixing ratio during the eleven-year cycle in the stratosphere and lower mesosphere. The analysis is performed by using multiple linear regression of the MERRA reanalysis dataset for the period 1979-2012. Furthermore, we describe possibilities of available dataset, which can be also considered for the study of the upper atmosphere. Results of this study show a qualitative agreement with other related studies in the stratosphere, we find substantial differences especially in the ozone concentrations above the stratopause. It has been shown more intensive sudden stratospheric warming during solar maxima and the associated impact on the Brewer-Dobson circulation in all fields of meteorological variables.
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Long-term changes of selected stratospheric fields related to circulation and enhancing greenhouse effect
Kozubek, Michal ; Laštovička, Jan (advisor)
In the present work we study behavior and trends of stratospheric wind in period of 1957-2002. We used reanalyzed daily data from project ERA-40. Results are shown in graphic form for 3 atmospheric levels. In each level we describe trends of wind velocities and directions separate into 2 seasons. We also compare trends of stratospheric wind with other characteristic indicators of atmospheric circulation. One of them is total columnar ozone and the second is mesopause midlatitude winds. Results of analyze halving adjustment of trends in wind directions and velocities for level 100, 50 and 10 hPa, too.
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The wider context of the impact of solar activity on mortality by cause in the Czech Republic
Podolská, Kateřina ; Rychtaříková, Jitka (advisor) ; Šídlo, Luděk (referee) ; Laštovička, Jan (referee)
The wider context of the impact of solar activity on mortality by cause in the Czech Republic Abstract The presented dissertation investigates the influence of extraterestrial phenomena, in the whole scope of their possible effects, on human population. It analyses the influence of climate-change induced fluctuation of solar activity on the population, as well as the impact of the concentration of cosmogenic radionuclides on human health. In the introduction, the manifestation of solar activity on Earth is described, the results of the present research is summarized, and the used methods of data processing and the data sources are described. The primary focus of this work is the association of mortality from the causes of death recorded under chapter IV. Diseases of the nervous system and chapter IX. Diseases of the circulatory system of the International Classification of Diseases, 10th revision (ICD-10) in the Czech Republic with the changes in the level of solar activity and its exceptional fluctuations. The main aim is to determine the possible link between the daily numbers of dead by the respective causes of death, by sex and age groups in the Czech Republic, on global as well as on geographically specific daily values of solar, ionospheric, and geomagnetic parameters in the years 1994-2013. These are...
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Methods for assessment of proinflammatory cytokines
Freislebenová, Hana ; Lašťovička, Jan (advisor) ; Hájková, Michaela (referee)
Sepsi and septic shock are the leading causes of death in intensive care units worldwide. Cytokines are important regulators of the immune response, which have crucial role in sepsis pathofysiology. This work deals with proin flammatory cytokines mainly interleukin 1, interleukin 6 and TNF-α and methods of their assessment. The purpose of this work is to compare immunohistochemis try methods like ELISA and ELISPOT with assessment of intracellular cytokines by flow cytometry.
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Subpopulations of lymphocytes in patients with prostate cancer during the immunotherapy by dendritic cell vaccine
Volmová, Martina ; Lašťovička, Jan (advisor) ; Palich Fučíková, Jitka (referee)
The bachelor thesis looks into the issue of cancer immunotherapy and it deals with possible use of immunotherapy by dendritic cell vaccine in patients with prostate cancer, which is now in phase I/II of clinical trials on the Department of Immunology at Faculty hospital Motol. The target of the practical part was to cope with the technology of preparation of blood samples and their measurement by means of the flow cytometry, with subsequent data evaluation and processing. The highlight of this work was the statistical evaluation of obtained data of lymphocyte subpopulations levels in peripheral blood, and their possible correlation with disease progression. The main subject of the research were subpopulations CD3 +, CD4 +, CD8+ , CD16+ , CD19+ and HLA-DR+. The monitoring of these subpopulations in patients treated by dendritic cell vaccine showed the decrease of both leukocyte and lymphocyte levels, reduction of CD4/CD8 index, decrease of relative and absolute numbers of CD4+ cells and significant decrease of both relative and absolute B lymphocyte numbers during the progress of the disease. Powered by TCPDF (www.tcpdf.org)
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Vertical variability of the 11 years solar cycle influence within the middle and higher atmosphere
Kuchař, Aleš ; Pišoft, Petr (advisor) ; Laštovička, Jan (referee)
This work investigates changes implied by variability of temperature, zonal wind and ozone mixing ratio during the eleven-year cycle in the stratosphere and lower mesosphere. The analysis is performed by using multiple linear regression of the MERRA reanalysis dataset for the period 1979-2012. Furthermore, we describe possibilities of available dataset, which can be also considered for the study of the upper atmosphere. Results of this study show a qualitative agreement with other related studies in the stratosphere, we find substantial differences especially in the ozone concentrations above the stratopause. It has been shown more intensive sudden stratospheric warming during solar maxima and the associated impact on the Brewer-Dobson circulation in all fields of meteorological variables.
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Global changes in the midlatitude stratosphere
Kozubek, Michal ; Laštovička, Jan (advisor) ; Halenka, Tomáš (referee) ; Metelka, Ladislav (referee)
Several phenomena in the middle latitude stratosphere are studied in the thesis. The reanalyses are utilized as a source of data for our study. Different reanalyses are compared each other and with observations and problems of reanalyses are shown. We are interested in connection between ozone, dynamics and other phenomena (Sudden Stratospheric Warmings, solar cycle, NAO etc.) in the stratosphere, mainly from 1979 to present using ERA-Interim, NCEP/NCAR reanalyses or satellite observations. The linear connection between total ozone difference and 100 hPa eddy heat flux is found in winter middle latitudes. Ozone trends in Europe and China are analysed. The meridional and zonal wind is also studied using MERRA reanalysis and model output (CCM SOCOL v3.0). The comparison of geographical distribution of geopotential height and meridional wind is done. Differences between MERRA and CCM SOCOL v3.0 has been observed for geopotential hight and meridional wind for winter season.
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Long-term changes of selected stratospheric fields related to circulation and enhancing greenhouse effect
Kozubek, Michal ; Laštovička, Jan (advisor)
In the present work we study behavior and trends of stratospheric wind in period of 1957-2002. We used reanalyzed daily data from project ERA-40. Results are shown in graphic form for 3 atmospheric levels. In each level we describe trends of wind velocities and directions separate into 2 seasons. We also compare trends of stratospheric wind with other characteristic indicators of atmospheric circulation. One of them is total columnar ozone and the second is mesopause midlatitude winds. Results of analyze halving adjustment of trends in wind directions and velocities for level 100, 50 and 10 hPa, too.
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