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Functional analysis of plant Arp2/3 complex subunits
Kukla, Jakub ; Schwarzerová, Kateřina (advisor) ; Honys, David (referee)
1. Abstract ARP2/3 complex is well studied in case of animals, it plays key roles in motility of cells and intracellular organels. It's malfunctions result in severe growth disorders and even lethality of affected cells. On the contrary, plant cells do not exhibit such dramatic phenotype of ARP2/3 complex mutations like it is by animals. It is possible that just the different life strategies of plants and animals contribute to differences in a way how animal and plant cells use their cytoskeleton, where ARP2/3 complex is it's part as well. It is highly conserved 7 protein complex from yeast to human. His main functions are creation of new "de novo" actin filaments, actin branched filaments network. Some of the parasite organisms are capable of missusing its nucleator activity to actively move inside of host cell. Because of the plant cells are sourounded by the cell wall, which give them support in creating various shapes and also hinders active movement of the whole cell body, it is likely that ARP 2/3 complex could be possibly involved in novel plant specific functions as well. If we think about the different life strategy of plants and animals we can not ignore all the things these two kingdoms have in common regarding to cytoskeleton processes. That is the need both for vesicular transport and...
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Possibilities of Using the Six Sigma Method in a Company
Kukla, Jakub ; Fejfarová, Martina (advisor) ; Huml, Jan (referee)
Nowadays, business philosophy or methodology called Six Sigma is considered to be one of the leading tools of quality management. This bachelor thesis is focused on the description and practical demonstration of this methodology. Theoretical part of this thesis describes three different approaches to this methodology which can be understood as a tool of defects measurement, management system or methodology of continual improvement. The essential factor of Six Sigma philosophy is teamwork. This bachelor thesis concisely describes the main roles of the team members and their responsibilities. The key element of this thesis is the description of DMAIC model and its phases, outputs and tools used. Besides this, basic information about DMADV model which is used to design new processes can be found here. The practical part of this thesis describes the implementation of e-shop conversion rate increase project in the company Delmas s.r.o. The data on which the project is based are collected through quantitative and qualitative analysis, interview and company documentation analysis. Using the model DMAIC the data are transformed into the solution which is tested and implemented afterwards. The final part of this thesis summarizes the results of this project, its economical impact and future recommendations.
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