|
|
Accounting Directives for Company
Kuchaříková, Petra ; Srbová, Pavla (referee) ; Pěta, Jan (advisor)
The bachelor’s thesis deals with creation of internal directive for inventory management in a selected entity. The first part of the thesis is devoted to providing a theoretical basis for internal directives, inventory management, record - keeping, valuation, accounting methods and inventory auditing. The following part comprises basic information about the company, a financial analysis of its statements and an analysis of the current status of its inventory management directives. In the last part, a proposal for an internal directive focused on inventory management is presented based on the acquired knowledge and results of the analysis.
|
|
|
Effect of metformin on glucose tolerance in relation to fat content in diet
Kuchaříková, Petra ; Horáková, Olga (advisor) ; Škop, Vojtěch (referee)
Prevalence of obesity and associated diseases like type 2 diabetes has increased rapidly during last years. These diseases closely relate to each other. Obesity leads to insulin resistence, which directly precedes type 2 diabetes. Metformin is the most prescribed medicament for type 2 diabetic patients and insulin resistant people. It improves glucose tolerance and insulin resistance. Enzyme AMP-activated protein kinase (AMPK) is strogly involved in metformin action. The latest studies using transgenic models lacking AMPK suggest, that notable part of mechanisms involved in metformin action is independent on AMPK. n-3 polyunsaturated fatty acids (n-3 PUFA), namely eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are abundant in sea fish, have beneficial effects on metabolism. These fatty acids lower plasma lipids and exert cardioprotective effects. n-3 PUFA also prevent development of insulin resistence and type 2 diabetes in rodents. The aim of this thesis was to characterise acute effects of metformin on glucose homeostasis, impact of short term diet intervention with diet rich in n-3 PUFA on metformin action and the role of insulin stimulated signalling pathways and AMPK. Results suggest that early effect of metformin is dose dependent and that single dose of metformin...
|
|
| |
|
|
Molecular mechanisms of insulin sensitivity in relation to fat content in diet
Kuchaříková, Petra ; Horáková, Olga (advisor) ; Klusoňová, Petra (referee)
Insulin resistance is a key component of the pathogenesis of metabolic syndrome and type 2 diabetes. Skeletal muscle is an important part of energy metabolism. It recieves, stores and uses most of the glucose from blood. Insulin stimulates glucose uptake, by promoting translocation of glucose transpoters to plasma membrane. It also increases the rate of protein, glycogen and triglyceride synthesis. When muscle is unable to respond to normal levels of circulating insulin, insulin resistance occurs. Insulin resistance leads to disruption of key metabolic processes. Fatty acid transport across the membrane is upregulated, whereas the ability to oxidize fatty acids is decreased. This imbalance leads to accumulation of lipid metabolites inside the cells. Lipid intermediates may interfere with insulin signalling. Inflammatory cytokines, particularly TNF, activate kinases that may inhibit the insulin signal transmission. Insulin resistance may be treated pharmacologically, but also physical activity and decrease of energy intake are important part of therapy. Also polyunsaturated fatty acids have beneficial effects on muscle insulin sensitivity.
|
|
|
Evaluation of Low - treshold services for children and youth in Hradec Králové
Kuchaříková, Petra ; Krahulcová, Beáta (advisor) ; Nová, Monika (referee)
My diploma thesis deals with Low-threshold services for children and youth and with fulfilling of the standards for quality in social services. Firstly I analysed problems of leisure time, historical events in the development in Low-threshold services for children and youth and binding documents for social workers. These problems are also discussed in relevance to the social services law. I mentioned the principles of low-threshold, aims of these establishments, target group and the whole process of this programme. One chapter deals with the management and financing and with social workers, their qualities, competences and supervision as the aide in self-education, and beneficiaries of social services and their characteristics. What threatens these beneficiaries are socio-pathological phenomenons, the most important ones are listed and I added the prevention. I described one mentioned establishment, which employs volunteers. For the evaluation of fulfilling of standards in social services I have chosen two low-threshold services for children and youth from Hradec Králové, where I have found if the standars are fulfilled or not by means of studying of methodology, observations and interviews with workers and beneficiaries. For conclusion I suggested some improvements which could be used in these establishments.
|
|
|
Effect of metformin on glucose tolerance in relation to fat content in diet
Kuchaříková, Petra ; Horáková, Olga (advisor) ; Škop, Vojtěch (referee)
Prevalence of obesity and associated diseases like type 2 diabetes has increased rapidly during last years. These diseases closely relate to each other. Obesity leads to insulin resistence, which directly precedes type 2 diabetes. Metformin is the most prescribed medicament for type 2 diabetic patients and insulin resistant people. It improves glucose tolerance and insulin resistance. Enzyme AMP-activated protein kinase (AMPK) is strogly involved in metformin action. The latest studies using transgenic models lacking AMPK suggest, that notable part of mechanisms involved in metformin action is independent on AMPK. n-3 polyunsaturated fatty acids (n-3 PUFA), namely eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are abundant in sea fish, have beneficial effects on metabolism. These fatty acids lower plasma lipids and exert cardioprotective effects. n-3 PUFA also prevent development of insulin resistence and type 2 diabetes in rodents. The aim of this thesis was to characterise acute effects of metformin on glucose homeostasis, impact of short term diet intervention with diet rich in n-3 PUFA on metformin action and the role of insulin stimulated signalling pathways and AMPK. Results suggest that early effect of metformin is dose dependent and that single dose of metformin...
|
|
|
Evaluation of Low - treshold services for children and youth in Hradec Králové
Kuchaříková, Petra ; Krahulcová, Beáta (advisor) ; Nová, Monika (referee)
My diploma thesis deals with Low-threshold services for children and youth and with fulfilling of the standards for quality in social services. Firstly I analysed problems of leisure time, historical events in the development in Low-threshold services for children and youth and binding documents for social workers. These problems are also discussed in relevance to the social services law. I mentioned the principles of low-threshold, aims of these establishments, target group and the whole process of this programme. One chapter deals with the management and financing and with social workers, their qualities, competences and supervision as the aide in self-education, and beneficiaries of social services and their characteristics. What threatens these beneficiaries are socio-pathological phenomenons, the most important ones are listed and I added the prevention. I described one mentioned establishment, which employs volunteers. For the evaluation of fulfilling of standards in social services I have chosen two low-threshold services for children and youth from Hradec Králové, where I have found if the standars are fulfilled or not by means of studying of methodology, observations and interviews with workers and beneficiaries. For conclusion I suggested some improvements which could be used in these establishments.
|
|
|
Molecular mechanisms of insulin sensitivity in relation to fat content in diet
Kuchaříková, Petra ; Horáková, Olga (advisor) ; Klusoňová, Petra (referee)
Insulin resistance is a key component of the pathogenesis of metabolic syndrome and type 2 diabetes. Skeletal muscle is an important part of energy metabolism. It recieves, stores and uses most of the glucose from blood. Insulin stimulates glucose uptake, by promoting translocation of glucose transpoters to plasma membrane. It also increases the rate of protein, glycogen and triglyceride synthesis. When muscle is unable to respond to normal levels of circulating insulin, insulin resistance occurs. Insulin resistance leads to disruption of key metabolic processes. Fatty acid transport across the membrane is upregulated, whereas the ability to oxidize fatty acids is decreased. This imbalance leads to accumulation of lipid metabolites inside the cells. Lipid intermediates may interfere with insulin signalling. Inflammatory cytokines, particularly TNF, activate kinases that may inhibit the insulin signal transmission. Insulin resistance may be treated pharmacologically, but also physical activity and decrease of energy intake are important part of therapy. Also polyunsaturated fatty acids have beneficial effects on muscle insulin sensitivity.
|
|
| |
guest ::
