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Drug addiction and perinatal stress
Kroupová, Anna ; Šlamberová, Romana (advisor) ; Valeš, Karel (referee) ; Stuchlík, Aleš (referee)
Introduction: Methamphetamine (MA) belongs to the psychostimulants with a central stimulating and anorectic effect. It has been found that MA is the most frequently abused drug of drug-addicted pregnant women. Drug abuse of mother can cause worsening maternal behavior and delayed offspring development. Prenatal application of MA can also lead to long- term changes in behavior, cognition and social interaction. It was also shown that maternal injections induce long-lasting effects on stress responsiveness in adult progeny. Stress and drug addiction are therefore closely connected. In children, perinatal stress is associated with cognitive, behavioral, physical and emotional problems as well as with autism. In adults, it is linked to depression and schizophrenia. In animals, perinatal stress reduces social play and social behavior, increases anxiety and impairs cognitive functions. Aim: The aim of this thesis was to determine the effect of perinatal factors such as prenatal MA/stress and/or early postnatal stress on sensorimotor development of pups and their mothers' behavior during lactation period, social behavior and oxytocin levels in juvenile age and subsequently on cognitive functions and behavior of exposed offspring in adulthood. For all behavioral tests of offspring, we monitor the possible...
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Drug abuse and perinatal stress
Kroupová, Anna ; Šlamberová, Romana (advisor) ; Stuchlík, Aleš (referee) ; Valeš, Karel (referee)
Introduction: Methamphetamine (MA) belongs to the psychostimulants with a central stimulating and anorectic effect. It has been found that MA is the most frequently abused drug of drug-addicted pregnant women. Drug abuse of mother can cause worsening maternal behavior and delayed offspring development. Prenatal application of MA can also lead to long- term changes in behavior, cognition and social interaction. It was also shown that maternal injections induce long-lasting effects on stress responsiveness in adult progeny. Stress and drug addiction are therefore closely connected. In children, perinatal stress is associated with cognitive, behavioral, physical and emotional problems as well as with autism. In adults, it is linked to depression and schizophrenia. In animals, perinatal stress reduces social play and social behavior, increases anxiety and impairs cognitive functions. Aim: The aim of this thesis was to determine the effect of perinatal factors such as prenatal MA/stress and/or early postnatal stress on sensorimotor development of pups and their mothers' behavior during lactation period, social behavior and oxytocin levels in juvenile age and subsequently on cognitive functions and behavior of exposed offspring in adulthood. For all behavioral tests of offspring, we monitor the possible...
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The Jewish Institutions in Lower Silesia in the 1950's and 1960's
Kroupová, Anna ; Čapková, Kateřina (advisor) ; Stach, Stephan (referee)
This diploma thesis deals with Jewish institutions in Lower Silesia during the period of 50's and 60's of the 20th century. The area of focus is the Socio-Cultural Association of Jews (Towarzystwo Spoleczno-Kulturalne Zydów), which was historically the only Jewish association in Poland that was allowed to exist. The main aim of this thesis is to track down and analyse relationship of the representatives of the group with the communist party and its ideology in detail, since the party was not particularly inclined towards Jewish culture due to Israel's affinity with the West. Furthermore, after the introduction and analysis of the main sources and literature, the thesis briefly introduces a topic related to the restoration of life within the Jewish community after the World War II. After that, it concentrates on the formation and development of institutions and it follows the way members were educated in the spirit of socialism as well as how the Jewish culture was formed. The fundamental sources necessary for the study of this problematic are primarily files that came into existence as a result of certain activities of institutions, such as meetings of their bodies, documents informing about social life (invitations to events), repatriation records of the USSR saved in Archive of The Jewish...
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