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Nondestructive determination of nitrogen in biological and other materials by photon activation analysis
Krausová, Ivana ; Mizera, Jiří ; Chvátil, David ; Krist, Pavel ; Řanda, Zdeněk ; Kučera, Jan ; Štursa, Jan
A procedure has been developed for assaying nitrogen in biological materials by means of instrumental photon activation analysis (IPAA). The determination has been based on counting of the non-specific 511 keV annihilation gamma rays of 13N, product of the photonuclear reaction 14N(γ, n)13N and a pure positron emitter. IPAA allowed determination of nitrogen down to 1 wt.%. in selected biological reference standards - NIST RM 8433 Corn Bran, 1547 Peach Leaves, 8414 Bovine Muscle, and 1577b Bovine Liver. The optimized procedure was applied also to assaying nitrogen in pulverized nanodiamond intended for medical purposes.
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Non-destructive determination of nitrogen in biological and other materials by the photon activation analysis
Krausová, Ivana ; Mizera, Jiří ; Chvátil, David ; Krist, Pavel ; Řanda, Zdeněk ; Kučera, Jan ; Štursa, Jan
The study presents a procedure for assaying nitrogen in biologocial materials by means of instrumental photon activation analysis (IPAA). The determination has been based on counting of the non-specific 511 keV annihilation gamma rays of 13N, product of the photonuclear reaction 14N(γ, n)13N, which is a pure positron emitter. IPAA allowed determination of nitrogen down to 1 wt.%. in selected biological reference materials - NIST RM 8433 Corn Bran, 1547 Peach Leaves, 8414 Bovine Muscle, and 1577b Bovine Liver. The optimized procedure was applied also to assaying nitrogen in pulverized nanodiamond intended for medical purposes.
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The neutron flux characterization on the microtron MT25
Chvátil, David ; Králik, M. ; Granja, C. ; Krist, Pavel
Microtron is a small cyclic electron accelerator. When it is used as a source of neutrons, electrons must be converted to neutrons by means of nuclear reactions. Spectra of neutrons produced by high energy X-ray photons in lead and uranium targets installed on the microtron MT25 were measured by the Bonner sphere spectrometer with passive detectors of thermal neutrons. Neutron yield from uranium target was nearly two times higher than from the lead one.
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Computing of MT 25 Microtron Dynamic Behavior and Fast Simulation
Krist, Pavel ; Bíla, J. ; Chvátil, David
This paper presents the design of a mathematical model and its fast simulation developed for the setup of the control system of the MT 25 microtron, which is a cyclic electron accelerator. This type of accelerator has been controlled manually until now. The mathematical model is based on calculations of the electron motion in the accelerating cavity and vacuum chamber. The simulation diagram was created in Matlab – Simulink.
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Emergent Phenomena, Morphomatics and Theory of Complexity
Bíla, J. ; Krist, Pavel
This paper is devoted to knowledge and symbolical environments for grasping of emergent phenomena. Respecting the fact that the origin of shapes of nature has its essence in emergencies the paper turns attention to formalisms for direct work with such “shapes” (Morphomatics). There are described three environments for grasping of emergent phenomena especially environment 2 as a cognitive tool and environment 3 as dynamic relation between Macrostructure and Microstructure emphasizing their mutual interactions. As an example of formalism developed from synthesis of the introduced three environments is illustrated the use of theory of matroids (dual of Fano matroid) for case of supergravity D=11.
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Multivalentní glykomika v imunoterapii experimentálních nádorů
Vannucci, Luca ; Pospíšil, Miloslav ; Krist, Pavel ; Křen, Vladimír ; Huliková, Katarína ; Luptovcová, Martina ; Svoboda, Jan ; Kuldová, Markéta ; Bezouška, Karel ; Rossmann, Pavel ; Difato, Francesco ; Mosca, F. ; Fišerová, Anna
Lectin-like receptors can modulate the cytotoxic, regulatory and dendritic cell responses by their interactions. GN8 multivalent glycoconjugates are able to internalize inside and activate NKR-P1 positive cells inducing production of IFN-gamma and expression of CD69. The final effect is a modulation of anticancer immunity with reduction of cancer growth
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Interakce glycodendrimérů s nádorovým mikroprostředím
Pospíšil, Miloslav ; Vannucci, Luca ; Luptovcová, Martina ; Svoboda, Jan ; Huliková, Katarína ; Kuldová, Miloslava ; Bezouška, Karel ; Krist, Pavel ; Pešta, M. ; Fišerová, Anna
Potentiation of immunological parameters by multivalent glycodendrimers (PAMAM-GlcNAc8) against experimental mouse melanoma and rat colon or glioma cancer. PAMAM –GlcNAc8 induce biological effects at different levels of cancer microenvironmental components and concern both, effector and cancer cells
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Imunomodulační glykodendrimery mají afinitu k endoteliím nádorových a embryonálních cév. Mikroskopické průkazy a perspektivy využití
Vannucci, Luca ; Fišerová, Anna ; Krist, Pavel ; Křen, Vladimír ; Huliková, Katarína ; Luptovcová, Martina ; Rossmann, Pavel ; Difato, F. ; Mosca, F. ; Pospíšil, Miloslav
Glycodendrimers coated with N-acetyl-glucosamine and labeled with a fluorescent dye demonstrate special tropism to neogenerated endothelia in cancer capillaries. Same distribution was observed by confocal microscopy in the new vessels of rat embryo abdominal wall, as in placenta and yolk sack endothelia. Results suggests the presence of a commun target on evoluting endothelia, the nature of which is under investigation.
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