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National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
Acromegaly in patients with somatotroph pituitary adenomas - determining the expression level of proteins with а potential influence on the therapeutic response
 Krbalová, Lenka ; Macháček, Miloslav (advisor) ; Pejchal, Jaroslav (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: RNDr. Mgr. Lenka Krbalová Supervisor: RNDr. Miloslav Macháček, Ph.D. Consultant Supervisor: MUDr. Jiří Soukup, Ph.D. Title of the rigorous thesis: Acromegaly in patients with somatotroph pituitary adenomas - determining the expression level of proteins with a potential influence on the therapeutic response Acromegaly is a rare disease manifested by a wide variety of symptoms (enlargement of the acral parts of the body, macroglossia, neuropathy, hypertension, cardiomyopathy etc.). These symptoms significantly decrease quality of life and shorten life span. It is caused by increased secretion of growth hormone in adulthood. The cause of this increased secretion is most often a somatotroph adenoma. In most cases, the treatment of acromegaly requires a comprehensive approach. It is a combination of surgical intervention, radiotherapy and pharmacotherapy. Somatostatin analogues are mainly used in pharmacotherapy. These compounds have similar pharmacodynamic effects as somatostatin after binding to the somatostatin receptor. The administration of these compounds leads to a decrease in the secretory activity of the tumour and subsequently to the reduction of its volume. Octreotide and lanreotide belong...
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