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Packing properties of powders 2.
Kopecká, Milada ; Zatloukal, Zdeněk (advisor) ; Šklubalová, Zdeňka (referee)
In the theoretical part of the diploma theses, the structural characteristics of powders, the measurement conditions of the bulk volume were studied as well as the employment of method of autocorrelation in investigation of reproducibility of the measurements. In the experimental section, the results of repeated measurements of bulk volume of size fractions of sodium citrate and sorbitol are summarized together with values of the coefficients of autocorrelation needed for generation of the plots. The coefficients of autocorrelation were employed to validation of the measurement reproducibility of bulk volume of the free- flowable powder size fractions of the pharmaceutical excipients.
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Calorimetric evaluation of compatibility between the components of the mixtures for tableting
Kopecká, Milada ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
Kopecká Milada - Rigorózní práce - 2006 This work deals with the compatibility of a medical substance with 15 additives using the DSC method. Theoretical part of the work describes thermoanalytical methods, methods of thermal analysis, calorimetric methods and differential scanning calorimetry. Besides the work deals with the crystalline structure of solid compounds. The aim of experimental part of the work was the calorimetric evaluation of the medical substance itself, all additives and mixtures of medical substance with additives. The compatibility was measured by means of DSC 200 PC Netzsch. The result of the work was to prove the compatibility of the medical substance with lactose, Kopovidone, Povidone 25, silica, mannitol, Emcompress, magnesium stearate, and calcium stearate. Incompatibility was found out between the medical substance and glycerol behenate.
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Packing properties of powders 2.
Kopecká, Milada ; Zatloukal, Zdeněk (advisor) ; Šklubalová, Zdeňka (referee)
In the theoretical part of the diploma theses, the structural characteristics of powders, the measurement conditions of the bulk volume were studied as well as the employment of method of autocorrelation in investigation of reproducibility of the measurements. In the experimental section, the results of repeated measurements of bulk volume of size fractions of sodium citrate and sorbitol are summarized together with values of the coefficients of autocorrelation needed for generation of the plots. The coefficients of autocorrelation were employed to validation of the measurement reproducibility of bulk volume of the free- flowable powder size fractions of the pharmaceutical excipients.
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Calorimetric evaluation of compatibility between the components of the mixtures for tableting
Kopecká, Milada ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
Kopecká Milada - Rigorózní práce - 2006 This work deals with the compatibility of a medical substance with 15 additives using the DSC method. Theoretical part of the work describes thermoanalytical methods, methods of thermal analysis, calorimetric methods and differential scanning calorimetry. Besides the work deals with the crystalline structure of solid compounds. The aim of experimental part of the work was the calorimetric evaluation of the medical substance itself, all additives and mixtures of medical substance with additives. The compatibility was measured by means of DSC 200 PC Netzsch. The result of the work was to prove the compatibility of the medical substance with lactose, Kopovidone, Povidone 25, silica, mannitol, Emcompress, magnesium stearate, and calcium stearate. Incompatibility was found out between the medical substance and glycerol behenate.
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