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Myeloid - Derived Suppressor Cell in the Context of Tumor Microenvironment
Košťálová, Monika ; Šírová, Milada (advisor) ; Indrová, Marie (referee)
Today, tumors are considered not only as a complex of genetically mutated cells with pathological function of excessive proliferation, invasiveness and increased viability, but increased attention is paid for the tumor microenvironment created by the tumor itself. This microenvironment generates conditions, which differ from the normal tissues - for example local hypoxia, lactic acidosis and tumor- induced immunosupression - all these abnormalities lead to increased viability of the tumor tissue. Myeloid-derived suppressor cells (MDSCs) seem to be one of the main mediators of the escape from immunosurveillance. MDSCs represent a heterogenous cell population of myeloid origin. In active state, MDSCs produce enhanced amount of reactive oxygen species, nitrogen compounds and arginase, which represent the mechanisms of the suppression of the anti-tumor immune response. That makes MDSCs a promising therapeutic target. However, recent studies also point out the physiological role of MDSCs, which seems to be essential to consider for succesfull MDSCs targeting. Key words: Tumor microenvironment, immunosurveillance theory, immunoediting, myeloid-derived suppressor cells, immunosuppresion in tumors, therapeutic targeting of MDSCs, physiological role of MDSCs Powered by TCPDF (www.tcpdf.org)
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Healthy Lifestyle Presentation Online on the Coffee Drinking Example
Košťálová, Monika ; Zábrodská, Kristina (advisor) ; Soukup, Martin (referee)
The aim of the diploma thesis Healthy Lifestyle Presentation Online on the Coffee Drinking Examples to demonstrate the presentation of the healthy lifestyle on the example of the coffee consumption and show the media perception. The coffee consumption is considered as a part of the popular culture which makes it an ideal universal research item. The thesis provided the basic theoretical frame for the research compound of two parts which are trying to answer two research questions - how does the online platform present the coffee consumption - whether coffee has a positive or negative impact on health. The second research question was to investigate, whether this media presentation has the impact on its final consumers. For the first research part, the quantitative content analysis was used. It was revealed that 62 % of analyzed articles was in favor of health benefits of the coffee, so the majority opinion presented on the internet is that coffee has got a beneficial impact on human health. The second part of the research was realized as the two-steps qualitative experiment compound of two parts of demi-structured survey. Based on the search, the respondents were observed for a potential opinion change. It was found, that 52 % of the respondent changed their mind in favor of positive coffee impact...
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Myeloid - Derived Suppressor Cell in the Context of Tumor Microenvironment
Košťálová, Monika ; Šírová, Milada (advisor) ; Indrová, Marie (referee)
Today, tumors are considered not only as a complex of genetically mutated cells with pathological function of excessive proliferation, invasiveness and increased viability, but increased attention is paid for the tumor microenvironment created by the tumor itself. This microenvironment generates conditions, which differ from the normal tissues - for example local hypoxia, lactic acidosis and tumor- induced immunosupression - all these abnormalities lead to increased viability of the tumor tissue. Myeloid-derived suppressor cells (MDSCs) seem to be one of the main mediators of the escape from immunosurveillance. MDSCs represent a heterogenous cell population of myeloid origin. In active state, MDSCs produce enhanced amount of reactive oxygen species, nitrogen compounds and arginase, which represent the mechanisms of the suppression of the anti-tumor immune response. That makes MDSCs a promising therapeutic target. However, recent studies also point out the physiological role of MDSCs, which seems to be essential to consider for succesfull MDSCs targeting. Key words: Tumor microenvironment, immunosurveillance theory, immunoediting, myeloid-derived suppressor cells, immunosuppresion in tumors, therapeutic targeting of MDSCs, physiological role of MDSCs Powered by TCPDF (www.tcpdf.org)
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